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Matthew B. Wilkinson, MD, PhD
Transplant Surgery Fellow

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Hospital of the University of Pennsylvania
3400 Spruce Street
Philadelphia, PA 19104

Administrative Telephone: 215-662-6157

Contact Information (internal use only)



Matthew B. Wilkinson completed his undergraduate work at the South Carolina Honors College at the University of South Carolina, graduating summa cum laude in 2005.  He then moved on to the University of Texas Southwestern Medical Center at Dallas for a combined MD/PhD program. He completed 2 years of his MD and then started in the laboratory of Dr. Eric J. Nestler studying molecular mechanisms of depression. Dr. Nestler took a position at the Mount Sinai School of Medicine, and Matthew followed him there completing his MD and PhD at Mount Sinai. He then stayed at The Mount Sinai Hospital for a 5 year general surgical residency. During residency, he became interested in transplant and chose to pursue that as a career. He will be a transplant fellow for 2017 to 2019 and is interested in studying affective disorders in the pre and post transplant population.

2017 - present Instructor in Surgery
2012 - 2017 General Surgery Residency at The Mount Sinai Hospital
2008 - 2012 Icahn School of Medicine at Mount Sinai  MD/PhD
2005 - 2008 University of Texas Southwestern Medical Center at Dallas
2001 - 2005 South Carolina Honors College at the University of South Carolina
B.Ar. Sc.  summa cum laude
2017 ASTS
2012 - present ACS

Dissertation Title: Identification and Elucidation of Molecular Mechanisms of Depression in the Mouse Nucleus Accumbens
  1. Dias C, Dietz D, Mazei-Robison M, Sun H, Damez-Werno D, Ferguson D, Wilkinson M, Magida J, Gao V, Neve R, Nestler EJ.  Dishevelled-2 regulates cocaine-induced structural plasticity and Rac1 activity in the nucleus accumbens.  Neurosci Lett. 2015 Jun 26 598:23-28.
  2. Arango-Lievano M, Schwarz JT, Vernov M, Wilkinson MB, Bradbury K, Feliz A, Marongiu R, Gelfand Y, Warner-Schmidt J, Nestler EJ, Greengard P, Russo SJ, Kaplitt MG.  Cell-type specific expression of p11 controls cocaine reward.  Biol Psychiatry. 2014 Nov 15;76(10):794-801
  3. Feng J, Wilkinson M, Liu X, Purushothaman I, Ferguson D, Vialou V, Maze I, Shao N, Kennedy P, Koo J, Dias C, Laitman B, Stockman V, LaPlant Q, Cahill ME, Nestler EJ, Shen L.  Chronic cocaine-regulated epigenomic changes in mouse nucleus accumbens.  Genome Biol  14 Apr 22;15(4):R65.
  4. Iñiguez SD, Alcantara LF, Warren BL, Riggs LM, Parise EM, Vialou V, Wright KN, Dayrit G, Nieto SJ, Wilkinson MB, Lobo MK, Neve RL, Nestler EJ, Bolaños-Guzmán CA.  Fluoxetine exposure during adolescence alters responses to aversive stimuli in adulthood. J Neurosci. 2014 Jan 15;34(3):1007-21
  5. Tomasiewicz HC, Jacobs MM, Wilkinson MB, Wilson SP, Nestler EJ, Hurd YL.  Proenkephalin mediates the enduring effects of adolescent cannabis exposure associated with adult opiate vulnerability.  Biol Psychiatry. 2012 Nov 15;72(10):803-10.
  6. Wilkinson MB, Dias C, Magida J,  Mazei-Robison M, Lobo MK, Kennedy PJ, Dietz DM, Covington III HE, Russo SJ, Neve RL, Ghose S, Tamminga CA, Nestler EJ. A Novel Role of the WNT-Dishevelled-GSK3b Signaling Cascade in the Mouse
    Nucleus Accumbens in a Social Defeat Model of DepressionJ Neurosci 2011 Jun 22:31(25):9084-92
  7. Maze I, Feng J, Wilkinson MB, Sun H, Shen L, Nestler EJ. Cocaine dynamically regulates heterochromatin and repetitive element unsilencing in nucleus accumbens. Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):3035-40
  8. Cao JL, Covington HE 3rd, Friedman AK, Wilkinson MB, Walsh JJ, Cooper DC, Nestler EJ, Han MH. Mesolimbic dopamine neurons in the brain reward circuit mediate susceptibility to social defeat and antidepressant action. J Neurosci. 2010 Dec 8;30(49):16453-8.
  9. Chuang JC, Krishnan V, Yu HG, Mason B, Cui H, Wilkinson MB, Zigman JM, Elmquist JK, Nestler EJ, Lutter M. A beta3-adrenergic-leptin-melanocortin circuit regulates behavioral and metabolic changes induced by chronic stress. Biol Psychiatry. 2010 Jun 1;67(11):1075-82. Epub 2010 Jan 12. Erratum in: Biol Psychiatry. 2010 Jul 1;68(1):112.
  10. Wilkinson MB, Xiao G, Kumar A, LaPlant Q, Renthal W, Sikder D, Kodadek TJ, Nestler EJ. Imipramine treatment and resiliency exhibit similar chromatin regulation in the mouse nucleus accumbens in depression models. J Neurosci. 2009 Jun 17;29(24):7820-32.
  11. Renthal W, Kumar A, Xiao G, Wilkinson M, Covington HE 3rd, Maze I, Sikder D, Robison AJ, LaPlant Q, Dietz DM, Russo SJ, Vialou V, Chakravarty S, Kodadek TJ, Stack A, Kabbaj M, Nestler EJ. Genome-wide analysis of chromatin regulation by cocaine reveals a role for sirtuins. Neuron. 2009 May 14;62(3):335-48.
  12. Russo SJ, Wilkinson MB, Mazei-Robison MS, Dietz DM, Maze I, Krishnan V, Renthal W, Graham A, Birnbaum SG, Green TA, Robison B, Lesselyong A, Perrotti LI, Bolaños CA, Kumar A, Clark MS, Neumaier JF, Neve RL, Bhakar AL, Barker PA, Nestler EJ. Nuclear factor kappa B signaling regulates neuronal morphology and cocaine reward. J Neurosci. 2009 Mar 18;29(11):3529-37.
  13. Carle TL, Ohnishi YN, Ohnishi YH, Alibhai IN, Wilkinson MB, Kumar A, Nestler EJ.
    Proteasome-dependent and -independent mechanisms for FosB destabilization: identification of FosB degron domains and implications for DeltaFosB stability.
    Eur J Neurosci. 2007 May;25(10):3009-19.
  14. Wilson MA, Burghardt PR, Ford KA, Wilkinson MB, Primeaux SD.  Anxiolytic effects of diazepam and ethanol in two behavioral models: comparison of males and females.
    Pharmacol Biochem Behav. 2004 Jul;78(3):445-58.
2017 Arthur H. Aufses, Sr. Prize in Surgery
2017 Administrative Chief Resident Awared
2015 Medical Student Teaching Award for a Senior Resident 
2012 Eugene W. Friedman Prize for Clinical Excellence (Surgery) 
2012 Outstanding Senior Anatomy Teaching Assistant 

Matthew Wilkinson

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