Dr. Wein's clinical expertise and interests are primarily in the fields of urologic cancer and voiding function and dysfunction. He was one of the founding members of the Society of Urologic Oncology and was elected to membership in the other two groups that are concerned with the evaluation and management of cancer: The American Society of Clinical Oncology and the Society of Surgical Oncology. He has particular interest and expertise in the area of prostate cancer and serves as a member of the International Consultation in prostate cancer. Dr. Wein's expertise in the areas of voiding function and dysfunction are widely acknowledged, particularly in the areas of urinary incontinence, neurogenic dysfunction, overactive bladder, interstitial cystitis, and dysfunction secondary to prostate enlargement. He serves on the International Consultation for both urinary incontinence (of which he is co-chair) and benign prosatic hyperplasia. He has been on the faculty of and directed numerous seminars in these areas. His basic research has been in the area of the physiology and pharmacology of the lower urinary tract, with many important discoveries coming out of his laboratory, beginning in 1970 with progress continuing until the present. These include many of the initial studies on autonomic receptor type and binding in the lower urinary tract; the correlation between pharmacological characteristics and function of the bladder and urethra; the correlation of neuroanatomy, neurophysiology and neuropharmacology of the lower urinary tract, and the effects of outlet obstruction on bladder smooth muscle: anatomy, physiology, pharmacology, and function. His clinical research has been in the areas of urologic cancer (prostate, bladder, kidney, testicle) and in the areas of urinary incontinence, voiding difficulties secondary to prostatic enlargement, to neurologic disease or injury, interstitial cystitis, and in the area of techniques to evaluate patients with voiding problems.