Education | Health Care | Research | Site Map
Search:
Abraham Shaked, M.D., Ph.D.
Transplant Surgery
 
Research Publications, peer reviewed

Shaked A. Kidney Preservation under sub-zero temperatures. M.D. Thesis. Hebrew University School of Medicine. May 1982.

Shaked A. Role of Differential Class II Antigen Expression in Allo-stimulation by Human Monocyte Hybridomas. Ph.D. Thesis. City University of New York, July 1989.

Shaked A, Hadani M, Reinsod M. CT and VER follow-up of reversible visual loss with fracture of the optic canal. Acta Neurochirurigca 1982; 62: 91-94.

Gomori JM, Shaked A. Radiation-induced meningiomas. Neuroradiology 1982; 23: 211-212.

Shaked A. Shinar E, Freund H. Neutropenic typhlitis: a plea for conservatism. Dis Colon Rectum 1983; 26: 351-352.

Shaked A, Raz E, Romanov H. Asymptomatic highly vascularized superior mediastinal mass. Chest 1984; 86: 621-622.

Katz LB, Shaked A, Messer J. Colonic varices hemorrhage: Diagnosis and management. J Clin Gastroenterology. 1985; 7: 67-69.

Shaked A, Meretyk S, Pode D, Caine M. Nontraumatic spontaneous rupture of the urinary bladder. Can J Surg 1986; 29 107-109.

Shaked A, Shinar E, Freund H. Managing the neutropenic patient with acute perianal inflammation. Am J Surg 1986; 152: 510-512.

Gordon RE, Shaked A, Solano P. Taurine protects hamster bronchioles from acute NO2-induced alterations: a histologic, ultrastructure and freeze fracture study. Am J Pathol 1986; 125 585-600.

Shaked A, Sherris D, Mayer L. Isolation of fibroblast proliferation factor: Distinction from interleukin I. Current Surgery 1987; 44: 487-490.

Shaked A, Mayer L. Recognition of class II or non MHC allodeterminants by T. cells using human monocyte hybridomas. Transplant Proc 1988; 20, (no. 1, Suppl. 1): 267-268.

Shaked A. Busuttil RW. Auxiliary liver transplantation: a negative view point. Hepatology 1990; 12: 173.

Sperber K, Shaked A, Posnet D, Hirschman S, Bekesi G, Mayer L, Surface expression of CD4 does not predict susceptibility to infection with HIV-1 In monocytic cells. J Clin Lab. Immunol 1990; 4: 151-156.

Shaked A, Busuttil RW, Sher L, Makowka L. Diagnosis and treatment of early rejection in liver transplantation. Transplantation Sci 1991; 1: 18-23.

Binderow S, Shaked A. Acute appendicitis in patients with HIV+AIDS infection. Am J Surg 1991; 162: 9-12.

Shaked A, Larrick J, Fotino M, Mayer L. Generation and characterization of human monocyte hybridomas. J. Immunol Methods 1991; 140: 45-55.

Shaked A, Calderon I, Durst A. Safety of surgical procedures performed by residents. Arch Surg 1991; 126: 559-560.

Shaked A, Takiff H, Busuttil RW. The use of the supraceliac aorta for hepatic artery revascularization in liver transplantation. Surg Gynecol Obstet 1991; 173:198-202.

Shaked A, Sperber K, Mayer FL. Stimulation of distinct T cells in MLR using human macrophage hybridomas differentially expressing class II antigens. Transplantation 1991; 52:1068-1072.

Shaked A, Busuttil RW. Liver transplantation in patients with portal vein thrombosis and central portacaval shunts. Ann Surg 1991; 214: 696-702.

Sue P, Wilkinson A, Shaked A, Busuttil RW. Hepatorenal syndrome in liver transplantation. Am Surg 1991; 57: 806-809.

Brunicardi FC, Watt PC, Colonna JO, Gelabert H, Shaked A, Gingerich R. Paracrine regulation of islet cell secretion in the isolated perfused human pancreas. Surg Forum 1991; XLII: 165-167.

Shaked A, McDiarmid S, Harrison R, Busuttil RW. Gas gangrene of the liver following orthotopic liver transplantation. Surgery 1992; 4: 462-465.

Canfield CW, Hudnall SD, Colonna JO, Busuttil RW, Wilkinson AH, Danovitch G, Shaked A, Goldstein L, Rosenthal JT. Fulminant EBV associated lymphoproliferative disorders following OKT3 therapy. Clin Transpl 1992; 6:1-9.

Shaked A, Goldstein R, Klintmalm G, Drazan K, Husberg J, Busuttil RW. Portosystemic shunt versus orthotopic liver transplantation for the Budd-Chiari syndrome. Surg Gynecol Obstet 1992; 174:453-459.

Shaked A, Hoyos B, Mayer L. The role of differential class II antigen expression in stimulation of allo-geneic mixed lymphocyte reactions by human monocyte hybridomas. Transplantation 1992; 53:1341-1347.

Shaked A, Colonna JO, Goldstein L, Busuttil RW. The interrelation between sclerosing cholangitis and ulcerative colitis in patients undergoing liver transplantation. Ann Surg 1992; 215:598-605.

Konishi K, Shaked A, Egawa H, Ozawa K, Busuttil RW. Correlation of hepatic injury synthetic func-tion and mitochondria energy level in orthotopic liver transplantation. J Surg Res 1992; 52:466-571.

Takiff H, Shaked A, Francis DJ, Busuttil RW. Cystic neoplasm of the liver: lessons in management. Digestive Surgery 1992; 9:166-168.

Colonna JO, Shaked A, Gomes AS, Colquhoun SD, Jurim O, McDiarmid SV, Millis MJ, Goldstein LI, Busuttil RW. Biliary strictures complicating liver transplantation: Incidence, pathogenesis, management. Ann Surg 1992; 216:344-352.

Umeshita K, Monden M, Tono T, Hasuike Y, Kanai T, Gotoh M, Mori T, Seu P, Shaked A, Busuttil RW. Interleukin 6 (IL-6) in bile as a marker of allograft rejection following liver transplantation in man. Transplant Proc 1992; 24:1462-1464.

Colonna JO, Shaked A, Gelabert HA, Busuttil RW. Resection of the caudate lobe through the "bloody gulch". Surg Gynecol Obset 1993; 176:401-402.

Busuttil RW, Farmer DG, Shaked A, Rolandelli R, Colonna JO, Jurim O, Colquhoun SD, Bertstein C, Shanahan F, Robert M, Goldstein LI, McDiarmid SV. Successful combined liver and small intestine transplantation for short gut syndrome and liver failure. West J Med 1993; 158:184-188.

Egawa H, Shaked A, Konishi Y, McDiarmid SV, Vargas JH, Shimahara Y, Colonna JO, Yamamoto N, Ozawa K, Busuttil RW. Arterial ketone body ratio in pediatric liver transplantation. Transplantation 1993; 55:522-526.

McDiarmid SV, Colonna JO, Shaked A, Vargas J, Ament ME, Busuttil RW. Differences in oral FK506 dose requirements between adult and pediatric liver transplant patients. Transplantation 1993; 55:1328-1332.

Shiraishi M, Shaked A, Imagawa D. Farmer D, Hasuike Y, Busuttil RW. Monoclonal anti-tumor necrosis factor alpha (TNF?) antibody suppresses rejection, but enhances infectious complications in rat liver allograft recipients. Transplant Proc 1993; 25(1):128-129.

Farmer DG, McDiarmid SV, Kuniyoshi J, Robert ME, Shaked A, Busuttil RW. Intragraft expression of interleukin-2 and interferon-Gamma messenger RNA is a predictor of rejection in rat small intestine allografts. American College of Surgeons Surgical Forum Volume XLIV, proceedings of the 79th Annual Clinical Congress, October 1993, San Francisco, California. 1993; XLIV:426-428.

Shaked A, Thompson M, Wilkinson AH, Nuesse B, El-Khoury GF, Rosenthal JT, Danovitch GM, Busuttil RW. The role of combined liver/kidney transplantation in end-stage hepato-renal disease. Am Surg 1993; 59:605-609.

Colquhoun S, Shaked A, Jurim O, Colonna JO, Rosove M, Busuttil RW. Reversal of neutropenia with granulocyte colony-stimulating factor without precipitating liver allograft rejection. Transplantation 1993; 56:755-758.

Jurim O, Shaked A, Kiai K, Millis JM, Colquhoun SD, Busuttil RW. Celiac compression syndrome and liver transplantation. Ann Surg 1993; 218:10-12.

Sherman S, Shaked A, Cryer HM, Goldstein LI, Busuttil RW. Endoscopic management of biliary fistulas complicating liver transplantation and other hepatobiliary operations. Ann Surg 1993; 218:167-175.

McDiarmid SV, Colonna JO, Shaked A, Ament M, Busuttil RW. A comparison of renal function in cyclosporine-and FK-506-treated patients after primary orthotopic liver transplantation. Transplantation 1993; 56:847-853.

Farmer DG, Shaked A, Colonna JO, Olthoff KM, Jurim O, Colquhoun S, Millis JM, Busuttil RW. Radical resection combined with liver transplantation for foregut tumors. Am Surg 1993; 59:806-812.

Csete ME, Neelakanta G, Shaked A, Busuttil RW. Prolonged venovenous bypass for intraoperative failure of transplanted livers: A report of three cases. Transplantation 1993; 56:1290-291.

Shaked A, Vargas J, Csete ME, Kiai K, Jurim O, Colquhoun S, McDiarmid SV, Ament ME, Busuttil RW. Diagnosis and treatment of bowel perforation following pediatric orthotopic liver transplantation. Arch Surg 1993; 128:994-999.

Hasuike Y, Shaked A, Shiraishi M, Farmer D, Busuttil RW. Selective mesenteric lymphoid irradi-ation eliminates the effector cells of lethal graft vs. host disease, while protecting the radiosensitive intestinal tissue. Transplant Proc 1993; 25(1):1196-1197.

Colquhoun S, Shaked A, Jurim O, Colonna JO, Rosove M, Busuttil RW. Reversal of neutropenia with granulocyte colony-stimulating factor without precipitating liver allograft rejection. Transplantation. 1993; 56:1593-1595.

Jurim O, Colonna JO, Colquhoun SD, Shaked A, Busuttil RW. A stapling technique for liver resection. J Am College Surg 1994; 178:510-511.

Shaked A, Csete ME, Shiraishi M, Miller AR, Moen RC, Busuttil RW, Economou JS. Retroviral-mediated gene transfer into rat experimental liver transplant. Transplantation 1994; 57:32-34.

Farmer DF, Rosove MH, Shaked A, Busuttil RW. Current treatment modalities for hepatocellular carcinoma: A review. Ann Surg 1994; 236-247.

Shiraishi M, Csete ME, Yasunaga C, Drazan KE, Jurim O, Cramer DV, Busuttil RW, Shaked A. Regeneration-induced accelerated rejection in reduced-size liver grafts. Transplantation 1994; 57:336-340.

Karademir S, Csete ME, Shaked A, Finstead T, Hawkins R, Busuttil RW. The role of 99mT labeled DISIDA scan in the assessment of marginal liver grafts after orthotopic liver transplantation. Clin Transplant 1994; 8:54-58.

Colquhoun SD, Robert ME, Shaked A, Rosenthal JT, Millis JM, Jurim O, Busuttil RW. Transmission of CNS malignancy by organ transplantation. Transplantation 1994; 57:970-974.

Busuttil RW, Shaked A, Colquhoun SD, Jurim O, Millis JM, Nuesse BJ, Csete ME, Goldstein LI, McDiarmid SV. One thousand liver transplants: The lessons learned. Ann Surg 1994; 219: 490-499.

Csete ME, Drazan KE, van Bree M, McIntee DF, McBride WH, Bett A, Graham FL, Busuttil RW, Berk AJ, Shaked A. Adenovirus-mediated gene transfer in the transplant setting. Part I: Conditions for expression of transferred genes in cold preserved hepatocytes. Transplantation 1994; 57: 1502-1507.

Shaked A, Csete ME, Drazan KE, Wu L, Busuttil RW, Berk AJ. Adenovirus-mediated gene transfer in the transplant setting. Part II: Successful expression of transferred cDNA in syngeneic liver grafts. Transplantation 1994; 57:1508-1511.

Jurim O, Martin P, Shaked A, Busuttil RW. Liver transplantation for chronic hepatitis B in Asians. Transplantation 1994; 57: 1393-1395.

Jurim O, Shaked A, Rose S, Busuttil RW. Volvulus of the Roux-en-y hepatico-jejunostomy: a rare complication manifested by recurrent ascending cholangitis. International Surgery 1994; 79: 176-177.

Drazan KE, Shen XD, Csete ME, Zhang WW, Roth JA, Busuttil RW, Shaked A. In vivo adenoviral-mediated human p53 tumor suppressor gene transfer and expression in rat liver following resection. Surgery 1994; 8:197-203.

Morris, Jr. BD, Drazan KE, Csete ME, van Bree MP, Rosenthal JT, Shaked A. Adenoviral-mediated gene transfer to bladder in vivo. J of Urology 1994; 152:506-509.

Lo CM, Shaked A, Busuttil RW. Risk factors for liver transplantation across ABO barrier. Transplantation 1994; 58:543-547.

Farmer DG, McDiarmid SV, Kuniyoshi J, Robert ME, Shaked A, Busuttil RW. Intragraft expression of messenger RNA for interleukin-6 and tumor necrosis factor-alpha are predictors of rat small intestine transplant rejection. J Surg Res 1994; 57: 138-142.

Csete ME, Afra R, Mullen Y, Drazan KE, Benhamou PY, Shaked A. Adenoviral-mediated gene transfer to pancreatic islets does not alter islet function. Transplant Proc 1994; 26: 756-757.

Jurim O, Gelabert HA, Shaked A, Nuesse BJ, McDiarmid SV, Busuttil RW. Reduced graft OLT for emergency indications in pediatric patients. Transplant Proc 1994; 26:195.

McDiarmid SV, Farmer DG, Kuniyoshi JS, Robert M, Khadavi A, Shaked A, Busuttil RW. Intragraft cytokine and cytotoxic T lymphocyte (CTL) specific protein expression are predictors of rat small intestine transplant rejection. Transplant Proc 1994; 26: 1520-1521.

Drazan KE, Csete ME, Shen XD, Busuttil RW, Berk A, Shaked A. Hepatic liver function is preserved after adenoviral-mediated gene transfer. J Surg Res 1995; 59:299-304.

McDiarmid SV, Farmer DG, Kuniyoshi JS, Robert M, Khadavi A, Shaked A, Busuttil RW. The correlation of intragraft cytokine expression with rejection in rat small intestine transplantation. Transplantation 1994; 58:690-697.

Badie B, Drazan KE, Shaked A, Black K. Adenoviral-mediated p53 gene delivery induces cell death in cultured 9L glioma cells. Neurological Science 1994; (In press).

Shiraishi M, Prager MC, Yasunaga C, McDiarmid SV, Vannice JL, Busuttil RW, Shaked A. The inhibitor cytokine IL-1 receptor antagonist, synergistically augments cyclosporine immunosuppression in a rat cardiac allograft model. J Surg Research 1995; 58:465-470.

Jurim O, Shaked A. Reduced-size grafts -- The solution for hepatic artery thrombosis after pediatric liver transplantation? J Ped Surg 1995; 30:53-55.

Csete ME, Drazan KE, Benhamou PY, Shen XD, McIntee DF, Afra R, Mullen Y, Shaked A. Efficient gene transfer to pancreatic islet mediated by adenoviral vectors. Transplantation 1995; 59:763-768.

Drazan KE, Shen XD, Busuttil RW, Csete M, Shaked A. Gene transfer in the transplant setting III: Variables affecting recombinant gene expression in liver grafts. Transplantation 1995; 59:670-673.

McDiarmid SV, Farmer DG, Kuniyoshi JS, Robert M, Khadavi A, Shaked A, Busuttil RW. Perforin and granzyme B: Cytolytic proteins up regulated during rejection of rat small intestine allgorafts. Transplantation. 1995; 59:762-766.

Badie B, Drazan KE, Kramar MH, Shaked A, Black KL. Adenovirus-mediated gene delivery inhibits 9L glioma growth in rats. Neurol Res 1995; 17:209-216.

Lo CM, Shaked A, Drazan K, Yersiz H, Jurim O, Busuttil RW. Variables affecting transplantation across ABO blood groups. Transplant Proc 1995; 27:1159.

Drazan KE, Shen XD, Wu L, Jurim O, Busuttil RW, Shaked A. Adenoviral-mediated gene transfer to liver xenografts results in successful expression and protein production. Transplant Proc 1995; 27:331-332.

Qin L, Chavin KD, Ding Y, Favaro JP, Woodward JE, Lin J, Tahara H, Robbins P, Shaked A, Ho D, Sapolsky R, Bromberg JS. Multiple vectors effectively achieve gene transfer in a murine cardiac transplantation model. Transplantation 1995; 59:809-816.

Millis JM, Imagawa DK, Olthoff KM, Martin P, Gomes A, Shaked A, Yersiz H, Drazan K, Jurim O, Goldstein LI, Busuttil RW. T.I.P.S.: Impact on liver transplantation. Transplant Proc 1995; 27:1252-1253.

Farmer DG, Shaked A, Olthoff KM, Imagawa DK, Millis JM, Busuttil RW. Evaluation, operative management and outcome after liver transplantation in children with biliary atresia and situs inversus. Ann Surg 1995; 222:47-50.

Drazan KE, Wu L, Olthoff KM, Jurim O, Busuttil RW, Shaked A. Transduction of hepatic allografts achieves local levels of viral IL-10 which suppress alloreactivity in vitro. J Surg Res 1995; 59:219-223.

Olthoff KM, Rosove MH, Imagawa DK, Shackleton CR, Farmer D, Martin P, Goldstein LI, Shaked A, Busuttil RW. Adjuvant chemotherapy improves survival following liver transplantation for hepatocellular carcinoma. Ann Surg 1995; 221:734-741.

Shackleton CR, Jurim O, McDiarmid SV, Martin P, Shaked A, Maxfield A, Pakrasi AL, Melinek J, Ament M, Vargas J, Millis JM, Imagawa DK, Olthoff KM, Goldstein LI, Busuttil RW. Living donor liver transplantation: Potential treatment of choice for pediatric recipients. Am J Surgery 1995; 169:529-532.

Winston D, Wirin D, Shaked A, Busuttil RW. Long-term cytomegalovirus prophylaxis in liver transplant recipients: A randomized comparison of ganciclovir and high-dose acyclovir. Lancet 1995; 346(8967):67-74.

Farmer DG. Shaked A. McDiarmid SV. Olthoff KM. Millis JM. Imagawa DK. Colonna JO. Robert ME. Lewin K. Goldstein LI. Busuttil RW. Small intestine transplantation at the University of California, Los Angeles. Transplant Proc 1996; 28: 2746-2747.

Shackleton C, Martin P, Melinek J, Stothers L, Millis JM, Olthoff KM, Imagawa DK, Kinkhabwala M, Rudich S, Seu P, Shaked A, McDiarmid SV, Goldstein LI, Busuttil RW. Lack of correlation between the magnitude of preservation injury and the incidence of acute rejection, need for OKT3 or conversion to FK506 in cyclosporine treated primary liver allograft recipients. Transplantation 1995; 60:554-558.

Yersiz H, Shaked A, Olthoff KM, Imagawa DK, Shackleton C, Martin P, Busuttil RW. Correlation between donor age and the pattern of liver graft recovery after transplantation. Transplantation 1995; 60:790-794.

Sherman S, Jamidar P, Shaked A, Kendall B, Goldstein L, Busuttil RW. Biliary tract complications after orthotopic liver transplantation: Endoscopic approach to diagnosis and therapy. Transplantation 1995; 60:467-470.

Jurim O, Shackleton CR, McDiarmid SV, Martin P, Shaked A, Millis JM, Imagawa DK, Olthoff KM, Maxfield A, Pakrasi AL, Melinek J, Ament M, Vargas J, Goldstein LI, Busuttil RW. Living-Donor Liver Transplantation at UCLA. Am J Surg 1995; 169:529-532.

Winston DJ, Imagawa DK, Holt CD, Kaldas F, Shaked A, Busuttil RW. Long-term ganciclovir prophylaxis eliminates serious cytomegalovirus disease in liver transplant recipients receiving OKT3 therapy for rejection. Transplantation 1995; 60:1357-1360.

Seu P, Olthoff KM, Rudich S, Kinkhabwala M, Imagawa DK, Neelankanta G, Goldstein LI, Martin P, Shackleton CR, Shaked A, Busuttil RW. Liver transplantation for fulminant hepatic failure in a Jehovah’s witness. Clin Transplant 1996; 10:404-407.

Imagawa DK, Olthoff KM, Hasan Y, Shackleton CR, Colquhoun SD, Shaked A, Busuttil RW. Rapid en bloc technique for pancreas-liver procurement. Transplantation 1996; 61:1605-1609.

Farmer DG, Shaked A, McDiarmid SV, Olthoff KM, Imagawa DK, Millis JM, Robert ME, Lewin K, Goldstein LI, Busuttil RW. Small intestine transplantation: The University of California Los Angeles Experience. Transplant Proc 1996;28:2746-47.

Imagawa, DK, Olthoff KM, Yersiz H, Shackleton CR, Colquhoun SD, Shaked A, Busuttil RW. Rapid en bloc technique for pancreas-liver procurement: Improved early liver function. Transplantation 1996;28:2746-2747.

Umeshita K, Monden M, Tono T, Hasuike Y, Kanai T, Gotoh M, Mori T, Shaked A, Busuttil RW. Determination of the presence of interleukin-6 in bile after orthotopic liver transplantation: Its role in the diagnosis of acute rejection. Ann Surg 1996; 223:204-211.

Werthman PE, Drazan KE, Rosenthal JT, Shalili R, Shaked A. Adenoviral-p53 gene transfer to orthotopic and peritoneal murine bladder cancer. J Urol 1996; 155(2):753-756.

Dawson S 3rd, Imagawa DK, Cecka JM, Gjertson DW, Shackleton CM, Shaked A, Busuttil R. UCLA liver transplantation: analysis of the first 1,000 patients. Clin Transplant 1994;189-195.

Drazan KE, Wu L, Olthoff KM, Shen XD, Gelman A, Shaked A. Adenovirus-mediated gene transfer in the transplant setting: Early events after orthotopic transplantation of liver allografts expressing TGF- ?1. Transplantation 1996; 62:1080-1084.

Drazan KE, Hebebrand D, Shaked A, Jones NF. Gene transfer during limb replantation. J Reconstr Microsurg 1997;13:383-387.

Jurim O, Martin P, Winston DJ, Shackleton C, Holt C, Feller J, Csete M, Shaked A, Imagawa D, Olthoff KM, Lau JYN, Busuttil RW. Failure of ganciclovir prophylaxis to prevent allograft reinfection following orthotopic liver transplantation for chronic hepatitis B infection. Liver Transplant Surg 1996;2:370-374.

Seu P, Shackleton CR, Shaked A, Imagawa DK, Olthoff KM, Rudich ST, Kinkhabwala J, Busuttil RW. Improved results of liver transplantation in patients with portal vein thrombosis. Arch Surg 1996;131:840-845.

Millis M, Melinek J, Csete M, Imagawa DK, Olthoff KM, Neelankanta G, Braunfeld MYC, Sopher MJ, Chan SM, Pregler JL, Yersiz H, Busuttil AA, Shackleton CR, Shaked A, Busuttil RW. Randomized controlled trial to evaluate flush and reperfusion techniques in liver transplantation. Transplantation 1997;63:397-403.

Drazan KE, Shaked A, Olthoff KM, Imagawa D, Jurim O, Kiai K, Shackleton C, Busuttil RW. Etiology and management of adult hepatic artery thrombosis after orthotopic liver transplantation. Am Surg 1996;62:237-240.

Drazan KE, Wu L, Bullington D, Shaked A. Viral IL-10 gene therapy inhibits TNF-alpha and IL-1beta, not IL-6 in the newborn endotoxemic mouse. J Ped Surg 1996; 31:411-414.

Benhamou PY, Mullen Y, Shaked A, Bahmiller D, Csete M: Decreased alloreactivity to human islets secreting recombinant viral interleukin-10. Transplantation 1996;62:1306-1312.

Weber M, Deng S, Kucher T, Shaked A, Ketchum, Brayman K: Adenoviral transfection of isolated pancreatic islets: A study of programmed cell death (Apoptosis) and islet function. J Surg Res:1997;69:23-32.

Olthoff KM. Rosove MH. Shackleton CR. Imagawa DK. Farmer DG. Northcross P. Pakrasi AL. Martin P. Goldstein LI. Shaked A. Busuttil RW. Continuous infusional 5-fluorouracil chemotherapy. Ann Surg 1996; 224: 686.

Deng S. Ketchum RJ. Yang ZD. Kucher T. Weber M. Shaked A. Naji A. Brayman KL. IL-10 and TGF-beta gene transfer to rodent islets: effect on xenogeneic islet graft survival in naive and B-cell-deficient mice. Transplant Proc 1997; 29: 2207-2208.

Deng S. Yang ZD. Ketchum RJ. Kucher T. Weber M. Shaked A. Naji A. Brayman KL. Transfer of genes for IL-10 and TGF-beta to isolated human pancreatic islets. Transplant Proc 1997; 29: 2206.

Deng S. Ketchum RJ. Kucher T. Weber M. Shaked A. Naji A. Brayman KL. IL-10 and TGF-beta gene transfer for xenogeneic islet transplantation: comparison of effect in concordant vs discordant combination. Transplant Proc 1997; 29: 2204-2205.

Holt CD. Winston DJ. Kubak B. Imagawa DK. Martin P. Goldstein L. Olthoff K. Millis JM. Shaked A. Shackleton CR. Busuttil RW. Coccidioidomycosis in liver transplant patients. Clin Infect Dis 1997; 24: 216-221.

Weber M. Deng S. Kucher T. Shaked A. Ketchum RJ. Brayman KL. Increased DNA fragmentation in isolated rat islets following 24 hour co-culture with cytokine transgene-bearing adenovirus is dose dependent, but does not reduce glucose-stimulated insulin secretion. Transplant Proc 1997; 29: 1728-1729.

Olthoff KM. Da Shen X. Gelman A. Turka L. Shaked A. Adenovirus-mediated gene transfer of CTLA4Ig to liver allografts results in prolonged survival and local T-cell anergy. Transplant Proc 1997; 29: 1030-1031.

Shaked A. Olthoff K. Sellers M. Chen XD. Gelman A. Tolerance to a second donor-matched allograft following local immune modulation using transfer of sequences encoding CTLA4Ig. Transplan Proc 1997; 29: 1026.

Deng S. Ketchum RJ. Kucher T. Weber M. Shaked A. Naji A. Brayman KL. Denoviral transfec-tion of canine islet xenografts with immunosuppressive cytokine genes abrogates primary non-function and prolongs graft survival. Transplant Proc 1997; 29: 770.

Sellers M. Singer A. Maller E. Olthoff K. Jacobowski D. Shaked A. Incidence of late acute rejection and progression to chronic rejection in pediatric liver recipients. Transplant Proc. 1997; 29: 428-9.

Shaked A: The use of T tube in liver transplantation. Liver Transplant Surg 1997;3:S22-S23.

Shaked A, Nunes FA, Olthoff KM, Lucey MR: Assessment of liver function: Pre-and peri-transplant evaluation. Clin Chem:1997;43:8:1539-545.

Qin L, Ding, Y, Pahud, DR, Robson ND, Shaked A, Bromberg JS: Adenovirus-mediated gene transfer of viral interleukin-10 inhibits the immune response to both alloantigen and adenoviral antigen. Hum Gene Ther:1997;8:1365-1374.

Weber M, Deng S, Olthoff K, Naji A, Barker CF, Shaked A, Brayman KL. Organ transplantation towards the twenty first century. Uro Clin North Am 1998;25:51-61.

Cherukuri R, Haskal ZJ, Shaked A. Percutaneous thrombolysis and stent placement for the treat-ment of portal vein thrombosis after liver transplantation: Long term follow-up. Transplantation 1998; 65:1124-1126.

Olthoff KM, Judge TA, Gelman A, Shen X, Hancock WW, Linsley PS, Turka LA, Shaked A. Adenovirus-mediated gene transfer into cold-preserved liver allografts: Survival pattern and tolerance following transduction with CTLA4Ig. Nat Med 1998;4:194-200.

Rosengard BR, Shaked A. Persistence of donor antigen is necessary for maintenance of xenotolerance—a parallel to allogeneic systems. Transplantation 1999;68(8):1095-1096.

Liu C, Deng S, Yang Z, Kucher T, Guo F, Gelman A, Chen H, Naji, Shaked A, Brayman KL. Local production of CTLA4-Ig by adenoviral-mediated gene transfer to the pancreas induces permanent allograft survival and donor-specific tolerance. Transplant Proc 1999;31:625-626.

Marcucci L, Shaked A, Maller ES, Rand EB, Hahn ES, Higuchi NH, Barker CF, Olthoff KM. Supraceliac aortic pseudoaneurysms following liver transplantation in infants. Transplantation 1999;68(10):1617-1619.

Zamir G, Olthoff K, Nunes F, Markmann J, Zeldin G, Stewart C, Weinreib R, Rand E, Maller E, Lucey M, Shaked A. Liver transplantation at the University of Pennsylvania and the Children’s Hospital of Philadelphia. Clin Transplant 1999;223:229.

Zamir GA, Markmann, JF, Abrams J, Macatee MR, Nunes FA, Shaked A, Olthoff KM. The fate of liver grafts declined for subjective reasons and transplanted out of a local procurement organization. Transplantation 2000;70(8):1149-1154.

Pfau PR, Kochman ML, Long WB, Lewis JD, Lucey MR, Olthoff K, Shaked A, Ginsberg GG. Endoscopic management of postoperative biliary complication in orthotopic liver transplantation. Gastrointest Endosc 2000;52(1):55-63.

Porter D, Shaked A. Exploring the potential for graft vs. tumor response in a combine bone marrow and liver transplantation for large hepatocellular carcinoma. Transplantation 2000;69(10):2003-2004.

Venkataramanan R, Shaw LM, Sarkozi L, Mullins R, Pirsch J, MacFarlane G, Scheller D, Ersfeld, Frick M, Fitzsimmons WE, Virgi M, Jain A, Brayman KL, Shaked A. Clinical utility of monitoring tacrolimus blood concentrations in liver transplant patients. J Clin Pharm 2001;41(5):542-51.

Velidedeoglu E, Desai NM, Campos L, Olthoff KM, Shaked A, Nunes F, Zeldin G, Stewart C, Blumberg E, Abrams J, Markmann JF. Effect of donor hepatitis C on liver graft survival. Transplantation Proceedings 2001;33:3795-3976.

Olthoff KM, Gelman AE, Zamir GA, Debonera F, Krasinkas AM, Shen X, Gao F, Shaked A. Pattern of alloimmune response in second same donor allografts after induction of tolerance using CTLA4Ig. Transplantation 2001;Dec 27:72(12):1952-1956.

Zamir G, Olthoff KM, Desai N, Markmann JF, Shaked A. Toward further expansion for organ pool for adult liver recipients-splitting the cadaveric liver into right and left lobes. Transplantation 2002;74(12):1757-1761.

Liu C, Deng S, Jiang K, Gelman A, Shaked A, Brayman KL. Mechanism of adenoviral- mediated CTLA4-IG gene-induced pancreatic allograft tolerance in rats. Trans Proc 2001; 33(1-2) 134.

Liu C, Jiang K, Deng S, Gelman A, Shaked A, Brayman K. Long-term localized transgene expres-sion in the pancreas achieved by intra-arterial adenoassociated virus-mediated gene transfer. Trans Proc 2001;33:603.

Shaked A, Lucey MR. Transplantation of liver grafts from living donors into adults. New Eng J Med 2001;345(12):923-924.

Singer AL, Olthoff KM, Kim H, Rand E, Zamir G, Shaked A. The role of plasmapheresis in the management of acute hepatic failure in the pediatric population. Ann Surg 2001;234(3):418-424.

Zamir G, Gelman A, Debonera F, Hardwigsen J, Que X, Aldeguer X, Martin M, Shaked A, Olthoff K. Modified AdCTLA-4 vector blocks alloimmune response in-vitro. J Surg Res 2001, 97:155-158.

Markmann JF, Shaked A. Immunomodulation by intrathymic injection of donor leukocytes in rhesus monkeys. Transplantation 2001;72(8):1351-1352
140. Shaked A. Splitting the cadaveric liver into the right and left lobes for two adult recipients. Liver Transplant 2002;8:82-84.

Aldeguer A, Debonera F, Shaked A, Krasinkas AM, Gelman AD, Que X, Zamir GA, Hiroyasu S, Kovalovich KK, Taub R, Olthoff KM. Interleukin-6 from intrahepatic cells of bone marrow origin is required for normal murine liver regeneration. Hepatology 2002;35(1):40-48.

Velidedeoglu E, Desai NJ, Campos L, Olthoff KM, Shaked A, Nunes F, Zeldin G, Stewart C, Blumberg E, Abrams J, Markmann JF. The outcome of liver grafts procured from hepatitis C-positive donor Transplantation 2002;73:582-587.

Abt P, Crawford M, Desai N, Markmann J, Olthoff K, Shaked A. Liver transplantation from controlled non-heart beating donors: An increased incidence of biliary complications. Transplantation 2003;75(10):1659-1663.

Shah JN, Haigh WG, Lee SP, Lucey MR, Brensinger C, Kochman ML, Long WB, Olthoff K, Shaked A, Ginsberg GG. Biliary casts following adult orthotopic liver transplantation: Clinical factors, treatment, and biochemical analysis. Amer J Gastroenterol 2003;98:1861-1867.

Debonera F, Krasinkas AM, Gelman AE, Aldeguer X, Que X, Shaked A, Olthoff KM. Dexamethasone inhibits early regenerative response of rat liver after cold preservation and transplantation. Hepatology 2003;38:1563-1572.

Krasinskas AM, Minda J, Saul SH, Shaked A, Furth EE. Redistribution of thorotrast into a liver allograft several years following transplantation: a case report. Mod Pathol 2004;17:117-120.

Htaik TT, Santaniello NA, Markmann JF, Shaked A, Clark TW. Treatment of obstructive ephro-ureteral clot with a rheolytic mechanical thrombectomy device. J Vasc Interv Radiol. 2003;14(7):933-936.

Abt PL, Mange KC, Olthoff KM, Markmann JF, Reddy KR, Shaked A. Allograft survival follow-ing adult to adult living donor liver transplantation Am J of Transplantation 2004;4(8):1302-1307.

Shah JN, Ahmad NA, Shetty K, Kochman ML, Long WB, Brensinger CM, Pfau PR, Olthoff K, Markmann J, Shaked A, Reddy R, Ginsberg GG. Biliary complications after adult living donor liver transplantation: Type, endoscopic management, and comparison to cadaveric transplantation. Am J of Gastroenterology 2004;99(7):1291-1295.

Shetty K, Timmins K, Brensinger C, Furth EE, Rattan S, Sun W, Rosen M, Shaked A, Reddy KR, Olthoff KM. Liver transplantation for hepatocellular carcinoma validation of present selection criteria in predicting outcome. Liver Transpl. 2004;10(7):911-918.

Stewart CA, Wertheim J, Olthoff K, Furth EE, Brensinger C, Markman J, Shaked A. Ascites after liver transplantation – A mystery. Liver Transpl 2004;10(5):654-660.

Velidedeoglu E, Bloom RD, Crawford MD, Desai NM, Campos L, Apt P, Markmann JW, Mange KC, Olthoff KM, Shaked A, Markmann JF. Early kidney dysfunction post liver transplantation predicts late chronic kidney disease. Transplantation 2004;77(4):553-556.

Shah JN, Ahmad NA, Shetty K, Kochman ML, Long WB, Brensinger CM, Pfau PR, Olthoff K, Markmann J, Shaked A, Reddy KR, Ginsberg GG. Endoscopic management of biliary complications after adult living donor liver transplantation. Am J Gastroenterol 2004 Jul;99(7):1291-1295.

Abt PL, Rapaport-Kelz R, Desai N, Frank A, Sonnad S, Rand E, Markmann JF, Shaked A, Olthoff KM. Survival among pediatric liver transplant recipients: Impact of segmental grafts. Liver Transpl 2004;10(10):1287.

Debonera F, Wang G, Xie J, Que X, Gelman A, Leclair C, Xin D, Shaked A, Olthoff KM. Severe Preservation Injury Induces Il-6/STAT3 activation with lack of cell cycle progression after partial liver graft transplantation. Am J Transplant 2004 Dec;4(12):1964-71.

Zamir G, Gelman AE, Olthoff KM, Debonera F, Aldeguer X, Shaked A. Patterns of transgene expression and viral clearance from the transplanted liver following ex vivo adenovirus-mediated gene transfer. J Hepatol 2004;41(5):714-20.

Olthoff KM, Brown RS Jr, Delmonico FL, Freeman RB, McDiarmid SV, Merion RM, Millis JM, Roberts JP, Shaked A, Wiesner RH, Lucey MR. Summary report of a national conference: Evolving concepts in liver allocation in the MELD and PELD era. Liver Transpl 2004 Oct;10 Suppl 10:A6-A22.

Blonski W, Reddy R, Shaked A, Siegelman E, Metz D. Liver Transplantation for metastatic neuroendocrine tumor; a case report and review of the literature. Liver Transpl 2004 (submitted).

Research Publications, Non-Peer Reviewed

Abt P, Shaked A. The Allograft Immune Response. Graft 2003;6(2)71-79.

Crawford M, Shaked A. The liver transplant operation. Graft 2003;6(2):98-109.

Abstracts: (last three years)

Crawford MD, Desai NM, Foreman LM, Timmons KJ, Markmann JF, Shaked A, Olthoff KM. Intra-operative steroids are not required for liver transplant immunosuppression. Amer J Transplantation 2002;2(3):198.

Debonera F, Que X, Aldeguer X, Abt P, Gelman AE, Shaked A, Olthoff KM. Partial liver grafts with prolonged cold preservation initiate blunted regenerative responses. Amer J Transplantation 2002;2(3):1563.

Que X, Debonera F, Gelman AE, Abt P, Shaked A, Olthoff KM. Intragraft IL-6 upregulation is criti-cal for graft survival after mouse liver transplantation (mOLT). Amer J Transplanta 2002;2(3):453.

Abt P, Desai N, Crawford M, Markmann J, Olthoff K, Shaked A. Liver transplantation from non-heart beating donors: An increased incidence of biliary complications. Amer J Transplantation 2002; 2(3):235.

Shetty K, Olthoff K, Read C, Stewart C, Reddy R, Shaked A. Donor-evaluation for living donor liver transplantation: Cost analysis of and medical benefits. Hepatology 2002;36(4Pt2):197A.

Debonera F, Que X, Aldeguer X, Abt P, Gelman AE, Shaked A, Olthoff KM. Partial liver grafts with prolonged cold preservation initiate blunted regenerative responses. Amer J Transplantation 2002;2(3):156.

Abt P, Desai N, Crawford M, Markmann J, Olthoff K, Shaked A. Liver transplantation from non-heart-beating donors: An increased incidence of biliary complications. Amer J Transplantation 2002;2(3):235.

Que X, Debonera F, Gelman AE, Abt P, Shaked A, Olthoff KM. Intragraft IL-6 upregulation is critical for graft survival after mouse liver transplantation (mOLT). Amer J Transplantation 2002;2(3):453.

Shetty K, Olthoff K, Read C, Stewart C, Reddy R, Shaked A. Donor evaluation for living donor liver transplantation: Cost analysis and medical benefits. Hepatology 2002;36(4 Pt2):197A.

Abt PL, Desai NJ, Crawford MD, Forman L, Markmann JW, Olthoff KM, Markmann JF.
Survival following liver transplantation from non-heart-beating donors. Hepatology 2002;36(4 Pt2):227A.

Shetty K, Brensinger CM, Timmins K, Rattan S, Jayaraman V, Crawford M, Furth E, Krasinkas A, Goldsmith J, Rosen M, Sun W, Reddy R, Shaked A, Olthoff K. Liver transplantation for hepatocellular carcinoma: Utility of selection criteria in predicting biological features and outcome. Hepatology 2002;36(4 Pt2):389A.

Vesga L, Forman L, Shaked A. The financial impact of liver transplantation. Am J Transplantation 2004;4:301.

Abt P, Rapaport-Kelz R, Frank A, Campos L, Markmann J, Shaked A, Olthoff K. Survival among pediatric liver transplant recipients: Impact of segmental grafts. Am J Transplantation 2003;3(5) 306.

Blumberg EA, Shaked A, Markmann J, Libetti G, Read C, Olthoff K. Outcomes of HIV
positive patients awaiting liver transplantation. Am J Transplantation 2003;3(5):433.

Olthoff KM, Timmins K, Shetty K, Sun W, Furth EE, Soulen M, Shaked A. Outcomes of pre-transplant local treatment for hepatocellular carcinoma in the setting of cirrhosis. Am J Transplantation 2003;3(5):553.

Hasz R, Nathan H, Edwards J, Abrams J, Mortiz M, Manzerbetia C, Reich D, Shaked A, Olthoff K, Yang H. Successful kidney and liver transplant outcomes from 150 non-heart beating donors (NHBD) in a single OPO. Am J Transplantation 2003;3(5):557.

Abt P, Andrew G, Xin D, Wang G, Xie J, Wells A, Olthoff K, Shaked A. Co-stimulatory blockade does not affect in vivo memory cell function while maintaining inhibition of alloimmune response. Am J Transplantation 2003;3(5):258.

Shetty , Sonnad S, Olthoff K, Shaked A, Reddy R. Impact of the MELD score on resource utilization following liver transplantation. Hepatology 2003;38(4):367A.

Shetty K, Olthoff K, Reddy R, Shaked A. Cost comparison between cadaveric and living donor liver transplantation. Hepatology 2003;38(4):652A.

Bloom R, Sayer G, Abt P, Shaked A, Berns J, Reddy R. Outcome of hepatitis C virus (HCV)-infected patients on the kidney transplant waiting list. Am J Transplantation 2003;3:503.

Stewart C, Crawford M, Furth O, Olthoff K, Shaked A. Does histology help predict aggressive recurrent HCV after transplant. Am J Transplantation 2004;3:522.

Hasz R, Nathan H, Edwards J, Abrams J, Moritz M, Manzerbetia C, Reich D, Shaked A, Olthoff K, Yang H. Successful kidney and liver transplant outcomes from 150 non-heart beating donors (NHBD) in a single OPO. Am J Transplantation 2004;3:557.

Krasinskas AM, Minda J, Saul SH, Shaked A, Furth EE. Redistribution of thorotrast into a liver allograft several years following transplantation: a case report. Mod Pathol 2004;17:117-120.

Gelman A, Abt, P, Xin D, Wang G, Debonera F, Olthoff K, Wells A, Shaked A. CTLA4Ig immunosuppression allows preservation of CD8+ T cell memory response to tumor antigens; a potential advantage in the transplant setting. Am J Transplantation 2004;4:191.

Shaked A, Tempie E, Hulbert S, Everhart J, Merion R. Rejection is decreased among adult recipients of living vs decreased donor liver allografts. Am J Transplantation 2004;4:268.

Halpern S, Asch D, Stock P, Shaked A, Blumberg E. Determinants of transplant surgeons' willingness to provide organs for patients infected with the hepatitis B, hepatitis C, and human immunodeficiency viruses. Am J Transplantation 2004;4:425.

Stephenson G, Abt P, Frank A, Kaminski M, Shaked A, Markmann J, Olthoff K. Successful transplantation of livers from older cadaveric donors. Am J Transplantation 2004;4:518.

Editorials, Reviews, Chapters

Imagawa DK, Strange SM, Shaked A, Seu P, Colonna JO, Farmer D, McDiarmid SV, Morrissey MP, Busuttil RW. Liver Transplantation at UCLA: Report of Clinical Activities. In: Clinical Transplants; Terasaki PL, Ed. UCLA Tissue Typing Laboratory, Los Angeles, 1991;13:127-134.

Shaked A, Goldstein R: Liver transplantation for Budd-Chiari syndrome. Transplantation of the Liver. Busuttil RW, Klintmalm G, eds. W.B. Saunders Co., Philadelphia. 1996;15:138-144.

Shaked A. Means of genetic modulation in liver transplantation. Transplantation of the Liver. Busuttil RW, Klintmalm G, eds. W. B. Saunders Co., Philadelphia. 1996;75:789-795.

Freund H, Shaked A. Neutropenic enterocolitis. Letter to the Editor, Dis. Colon & Rectum. 984; 27: 275.

Shaked A, Calderon I, Durst A. Safety of surgical procedures performed by residents. Letter to the Editor, Arch Surg. 1992; 127: 993.

Zamir, GA, Olthoff KM, Nunes, FA, Shaked A et al. Liver transplantation at the University of Pennsylvania and The Children’s Hospital of Philadelphia. Clinical Transplants; Cecka JM, Terasaki PL eds. UCLA Immunogenetics Center, Los Angeles, 1999;20:223-229.

Zamir G, Olthoff KM, Shaked A. Gene therapy and graft modification. Curr Opin Organ Transpl 2001;6:343-347.

Barker CF, Brayman KL, Markmann JF, Naji A, Olthoff KM, Shaked A. Transplantation of Abdominal Organs. In: Beauchamp, Evers, Matton, Eds. Sabiston Textbook of Surgery, 16th Edition, Chapter 25: pp 429-470, 2001.

Rand E, Olthoff KM. Pediatric Liver Transplantation. In: Lucey M. Neuberger J, Shaked A, Eds. Liver Transplantation, Chapter 10: pp 109-115, Landes Bioscience, 2002.

Rand E, Olthoff KM. Pediatric Liver Transplantation. In: Lucey M. Neuberger J, Shaked A, Eds. Liver Transplantation, Chapter 10: pp 109-115, Landes Bioscience, 2002.

Olthoff KM, Abt, PL, Shaked A. Liver Transplantation. In: Reddy KR, Long WB, Eds. Requisites in Gastroenterology, Volume 3: Hepatobiliary Tract and Pancreas, Chapter 12: pp 243-255, Mosby, 2004.

 


About Penn Medicine   Contact Us   Site Map   Privacy Statement   Legal Disclaimer   Terms of Use

Penn Medicine , Philadelphia, PA 1-800-789-PENN © 2009, The Trustees of the University of Pennsylvania