Kerdel F, Fraker DL, and Haynes HA. Necrotizing vasculitis from radiographic contrast media. J Am Acad Derm 10(1):25-29, Jan. 1984.

Fraker DL and Norton JA. Localization and resection of insulinomas and gastrinomas. JAMA 259(24):3601-3605, June 24, 1988.

Fraker DL, Stovroff MC, Merino MJ, and Norton JA. Tolerance to tumor necrosis factor in rats and the relationship to endotoxin tolerance and toxicity. J Exp Med 168(1):95-105, July 1, 1988.

Stovroff MC, Fraker DL, Swedenborg JA and Norton JA. Cachectin/tumor necrosis factor: A possible mediator of cancer anorexia in the rat. Cancer Res 48(16):4567-4572, Aug. 15, 1988.

Fraker DL, Norton JA, Saeed ZE, Maton PN, Gardner JD, Jensen RT. A prospective study of perioperative and postoperative control of acid hypersecretion in patients with Zollinger-Ellison syndrome undergoing gastrinoma resection. Surgery 104(6):1054-1063, Dec.1988.

Stavroff MC, Fraker DL, Norton JA. Cachectin activity in the serum of cachectin, tumor-bearing rats. Arch Surg 124(1):94-99, Jan. 1989.

Stovroff NC, Fraker DL, Travis WD and Norton JA. Altered macrophage activity and tumor necrosis factor: tumor necrosis and host cachexia. J Surg Res 46(5):462-469, May 1989.

Fraker DL, Merino MJ and Norton JA. Reversal of the toxic effects of cachectin by concurrent insulin administration. Am J Physiol 256(6 Pt 1):E725-E731, June 1989.

Sheppard BC, Fraker DL, and Norton JA. Prevention and treatment of endotoxin and sepsis lethality with recombinant human tumor necrosis factor. Surgery 106(2):156-162, Aug. 1989.

Fraker DL, Langstein HN and Norton JA. Passive immunization against tumor necrosis factor partially abrogates interleukin-2 toxicity. J Exp Med 170(3):1015-1020, Sept. 1, 1989.

Evans S, Matthews W, Perry R, Fraker DL, Norton JA and Pass HI. Effect of photodynamic therapy on tumor necrosis factor production by murine macrophages. J Natl Cancer Inst 82(1):34-39, Jan. 3, 1990.

Fraker DL, Sheppard BC and Norton JA. Impact of tolerance on anti-tumor efficacy of tumor necrosis factor in mice. Cancer Res 50(8):2261-2267, April 15,1990.

Fraker DL, Doppman JL, Shawker TH, Marx SJ, Spiegal AM, and Norton JA. Undescended parathyroid adenoma: an important etiology for failed operations for primary hyperparathyroidism. World J Surg 14(3):342-348, May/June 1990.

Sheppard BC, Venzon D, Fraker DL, Langstein HN, Jensen JC, and Norton JA. Prolonged survival of tumor bearing rats with repetitive low dose recombinant tumor necrosis factor. Cancer Res 50(13):3928-3933, July 1, 1990.

Darling G, Fraker DL, Jensen JC, Gorschboth CM and Norton JA. Cachectic effects of recombinant tumor necrosis factor in rats. Cancer Res 50(13):4008-4013, July 1, 1990.

Norton JA, Shawker TH, Doppman JL, Miller DL, Fraker DL, Cromack DT, Gordon P and Jensen RT. Localization and surgical treatment of occult insulinomas. Ann Surg 212(5):615-620, Nov. 1990.

Fraker DL, Travis WD, Merendino JJ, Zimering MB, Streetan EA, Weinstein LS, Marx SJ, Spiegal AM, Aurbach GD, Doppman JL and Norton JA. Locally recurrent parathyroid neoplasms as a cause for recurrent and persistent primary hyperparathyroidism. Ann Surg 213(1):58-65, Jan. 1991.

Danforth DR and Fraker DL. Splenectomy for the massively enlarged spleen. Am Surg 57(2):108-113, Feb. 1991.

Alexander HR, Doherty GM, Fraker DL, Block MI, Swedenborg JA and Norton JA. Human recombinant interleukin-1 protection against the lethality of endotoxin and experimental sepsis in mice. J Surg Res 50(5):421-424, May 1991.

Langstein HN, Doherty GM, Fraker DL, Buresh CM and Norton JA. The roles of interferon-gamma and tumor necrosis factor in an experimental rat model of cancer cachexia. Cancer Res 51(9):2302-2306, May 1, 1991.

Alexander HR, Sheppard BC, Jensen JC, Langstein HN, Buresh CM, Venzon D, Walker EC, Fraker DL, Stovroff MC and Norton JA. Treatment with recombinant tumor necrosis factor alpha protects rats against the lethality, hypotension, and hypothermia of gram negative sepsis. J Clin Invest 88(1):34-39, July 1991.

Fraker DL, Thom AK, Doherty GM, Langstein HN, Buresh CM, Norton JA. Tumor necrosis factor mediates the survival benefit of interleukin-2 in a murine pulmonary metastases model. Surg Oncology 1(1):1-9, Feb. 1992.

Alexander HR, Wong GH, Doherty GM, Venzon D, Fraker DL, Norton JA. Differentiation factor/leukemia inhibitory factor protection against lethal endotoxemia in mice: synergistic effect with IL-1 and TNF. J Exp Med 175(4):1139-1142, April 1, 1992.

Alexander HR, Doherty GM, Venzon DJ, Merino MJ, Fraker DL, Norton JA. Recombinant interleukin-1 receptor antagonist (IL-1ra): Effective therapy against gram-negative sepsis in rats. Surgery 112(2):188-194, Aug. 1992.

Thom AK, Fraker DL, Taubenberger JK, Norton JA. Effective regional therapy of experimental cancer with paralesional administration of tumor necrosis factor ? + interferon-?. Surg Oncology 1(4):291-298, Aug. 1992.

Thom AK, Fraker DL, Norton JA. IL-1 receptor antagonist (IL-1ra) augments IL-2 induced pulmonary vascular leak. J Surg Res 54(4):336-341, Apr. 1993.

Sugg SL, Norton JA, Fraker DL, Metz DC, Pisegna JR, Fishbeyn V, Benya RV, Shawker TH, Doppman JL, Jensen RT. A prospective study of intraoperative methods to find and resect duodenal gastrinomas. Ann Surg 218(2):138-144, Aug. 1993.

Block MI, Berg M, McNamara MJ, Norton JA, Fraker DL, Alexander HR. Passive immunization of mice against D factor blocks lethality and cytokine release during endotoxemia. J Exp Med 178(3):1085-1090, Sept. 1, 1993.

Metz DC, Kuchio M, Fraker DL, Venzon DJ, Jaffe G, Jensen RT, Stoffer-Stevenson M. Flow cytometry and Zollinger-Ellison Syndrome: relationship to clinical course. Gastroenterology 105(3):799-813, Sept. 1993.

Pisegna JR, Slimak GG, Strader DB, Metz DC, Orbuch M, Fishbeyn VA, Fraker DL, Norton JA, Maton PN, Jensen RT. Use of human recombinant alpha interferon in patients with metastatic gastrinoma: A prospective study. Gastroenterology 105(4):1179-1183, Oct. 1993.

Zeiger MA, Fraker DL, Pass HI, Nieman LK, Cutler BG, Jr., Chrousos GP, Norton JA. Effective reversibility of the signs and symptoms of hypercortisolism by bilateral adrenalectomy. Surgery 114(6):1138-1143, Dec. 1993.

Sugg SL, Fraker DL, Alexander HR, Doppman JL, Miller DL, Chang R, Skarulis MC, Marx SJ, Spiegel AM, Norton JA. Prospective evaluation of selective venous sampling for parathyroid hormone concentration in patients undergoing reoperations for primary hyperparathyroidism. Surgery 114(6):1004-1010, Dec. 1993.

Doppman JL, Nieman LK, Cutler GB, Jr, Chrousos GP, Fraker DL, Norton JA, Jensen RT. Adrenocroticotropic hormone-secreting islet cell tumors: Are they always malignant? Radiology 190(1):59-64, Jan. 1994.

Charnas LR, Luciano CA, Dalakas M, Gilliat RW, Bernardini I, Ishak K, Cwik VA, Fraker DL, Brushart TA, Gahl WA. Distal vacuolar myopathy in nephropathic cystinosis. Ann Neurol 35(2):181-188, Feb. 1994.

Jensen RT and Fraker DL. Zollinger-Ellison syndrome: Advances in the management of the gastric hypersecretion and the gastrinoma. JAMA 271(18):1429-1435, May 11, 1994.

Avila NA, Shawker TH, Fraker DL. Color flow Doppler ultrasound in metastatic melanoma to the gallbladder. J Clin Ultrasound 22(5):342-347, June 1994.

Berg M, Fraker DL, Alexander HR. Characterization of recombinant D0factor/leukemia inhibitory factor effect on lipoprotein lipase activity and mRNA in 3T3-LI adipocytes. Cytokine 6(4):425-432, July 1994.

Fraker DL, Norton JA, Alexander HR, Venzon DC, Jensen RT. Surgery in Zollinger Ellison syndrome alters the natural history of gastrinoma. Ann Surg 220(3):320-330, Sept. 1994.

Doppman JL, Shawker TH, Fraker DL, Alexander RB, Skarulis MC, Spiegel AM. Parathyroid adenoma within the vagus nerve. Am J Roent 163(4):943-945, Oct. 1994.

MacFarlane MP, Fraker DL, Shawker TH, Norton JA, Doppman JL, Chang RA, Skarulis M, Marx SJ, Spiegel AM, Alexander HR. Use of preoperative fine needle aspiration in patients undergoing reoperations for primary hyperparathyroidism. Surgery 116(6):959-965, Dec. 1994.

Billingsley KG, Fraker DL, Doppman JL, Norton JA, Shawker TH, Skarulis M, Marx SJ, Spiegel AM, Alexander HR. Localization and operative management of undescended parathyroid adenomas in patients with persistent primary hyperparathyroidism. Surgery 116(6):982-990, Dec. 1994.

Thom AK, Alexander HR, Andrich MP, Barker WC, Rosenberg SA, Fraker DL. Cytokine levels and systemic toxicity in patients undergoing isolated limb perfusion (ILP) with high-dose TNF, interferon-? and melphalan. J Clin Oncol 13(1):264-273, Jan. 1995.

Alexander HR, Grem JL, Hamilton JM, Pass HI, Hong M, Fraker DL, Steinberg SM, McAtee N, Allegra CJ, Johnston PG. Cancer J Sci Amer 1:49-54, 1995.

Weber HC, Venzon DJ, Fishbein VA, Orbuch M, Strader DB, Gibril F, Metz DC, Fraker DL, Norton JA, Jensen RT. Determinants of metastatic rate and survival in Zollinger-Ellison syndrome: A prospective long-term study. Gastroenterology 108(6):1637-1649, June 1995.

Fraker DL, Alexander HR, Andrich M, Rosenberg SA. Palliation of regional symptoms of advanced extremity melanoma by isolated limb perfusion with melphalan and high dose tumor necrosis factor. Cancer J Sci Amer 1:122-130, 1995.

Doppman JL, Chang R, Fraker DL, Norton JA, Alexander HR, Miller DL, Collier ES, Skarulis MC, Gorden P. Localization of insulinomas by intra-arterial stimulation with calcium. Ann Intern Med 123(4):269-273, Aug. 15, 1995.

Gorden P, Skarulis MC, Roach P, Comi RJ, Fraker DL, Norton JA, Alexander HR, Doppman JL. Plasma proinsulin-like component in insulinoma: A 25 year experience. J Clin Endocrinol Metabol 80(10):2884-2887, Oct. 1995.

Block MI, Fraker DL, Strassmann G, Billingsley KG, Arnold WS, Perlis C, Alexander HR. Endogenous D-factor activity partially mediates the toxic but not the therapeutic effects of tumor necrosis factor. Int J Cancer 63(2):245-249, Oct. 9, 1995.

Barker WC, Andrich MP, Alexander HR, Fraker DL. Continuous intraoperative external monitoring of perfusate leak using I-131 human serum albumin during isolated perfusion of the liver and limbs. Eur J Nucl Med 22(11):1242-1247, Nov. 1995.

Buell JF, Fraker DL, Doppman JL, Shawker TH, Skarulis MC, Spiegel AM, Marx SJ, Alexander HR. High cervical intravagal hypercellular parathyroid gland as the etiology of severe persistent primary hyperparathyroidism. Am Surgeon 61(11):943-946, Nov. 1995.

Yu KC, Alexander HR, Ziessman HA, Norton JA, Doppman JL, Buell JF, Nieman LK, Cutler GB, Jr, Chrousos GP, Fraker DL. Role of pre-operative iodocholesterol scintiscanning in patients undergoing adrenalectomy for Cushing's syndrome. Surgery 118(6):981-987, Dec. 1995.

MacFarlane MP, Fraker DL, Alexander HR, Norton JA, Lubensky I, Jensen RT. A prospective study of surgical resection of duodenal and pancreatic gastrinomas in multiple endocrine neoplasia type 1. Surgery 118(6):1108-1113, Dec. 1995.

Amikura K, Alexander HR, Norton JA, Doppman JL, Jensen RT, Nieman L, Cutler G, Chrousos G, Fraker DL. The role of surgery in management of ACTH-producing islet cell tumors of the pancreas. Surgery 118(6):1125-1130, Dec. 1995.

Chen CC, Skarulis MC, Fraker DL, Alexander HR, Marx SJ, Spiegel AM. Technetium-99m Sestamibi imaging before reoperation for primary hyperparathyroidism. J Nucl Med 36(12):2186-2191, Dec. 1995.

Billingsley KG, Fraker DL, Strassmann G, Loeser C, Alexander HR. Macrophage derived tumor necrosis factor augments tumor production of leukemia inhibitory factor and inter-leukin-6: Possible cellular mechanisms of cancer cachexia. Ann Surg Oncol 3(1):29-35, Jan. 1996.

Yu KC, Fraker DL, Ziessman HA. Atlas of iodocholesterol scintigraphy (NP-59) in Cushing's syndrome with CT and MR correlation. Clin Nucl Med 21(2):136-41, Feb. 1996.

Fraker DL, Alexander HR, Andrich M, Rosenberg SA. Treatment of patients with melanoma of the extremity using hyperthermic isolated limb perfusion with melphalan, tumor necrosis factor, and interferon-gamma: Results of a TNF dose escalation study. J Clin Oncol 14(2):479-489, Feb. 1996.

Jaskowiak N, Norton JA, Alexander HR, Doppman JL, Shawker T, Skarulis M, Marx S, Spiegel A, Fraker DL. A prospective trial evaluating a standard approach to reoperation for missed parathyroid adenoma. Ann Surg 224(3):308-322, Sept. 1996.

Brucker-Davis F, Reynolds JC, Skarulis MC, Fraker DL, Alexander HR, Weintraub BD, Robbins J. Two unusual causes of "false-positive" iodine-131 whole body scans for differentiated thyroid cancer. J Nucl Med 37(10):1690-1693, Oct. 1996.

Doppman JL, Skarulis MC, Chen CC, Chang R, Pass HI, Fraker DL, Alexander HR, Niederle B, Marx S, Norton JA, Wells SA, Spiegel AM. Parathyroid adenoma in the aortopulmonary window. Radiology 201(2):456-462, Nov. 1996.

Jaskowiak NT, Fraker DL, Alexander HR, Norton JA, Doppman JL, Jensen RT. Is reoperation for gastrinoma excision indicated in Zollinger-Ellison syndrome? Surgery 120(6):1055-1062, Dec. 1996.

Buell JF, Alexander HR, Norton JA, Yu KC, Fraker DL. Bilateral adrenalectomy for Cushing's syndrome: Anterior versus posterior surgical approach. Ann Surg 225(1):63-68, Jan. 1997.

Merryman P, Tannenbaum SH, Gralnick HR, Yu K, Arnold WS, Alexander HR, Fraker DL, Horne MK. Fibrinolytic and coagulant responses to regional limb perfusions of tumor necrosis factor, interferon-?, and/or melphalan. Thrombosis and Haemostasis 77(1):53-56, Jan. 1997.

Sarraf P, Frederich RC, Turner EM, Ma G, Jaskowiak NT, Rivet DJ, Flier JS, Lowell BB, Fraker DL, Alexander HR. Multiple cytokines and acute inflammation raise mouse leptin levels: Potential role in inflammatory anorexia. J Exper Med 185(1):171-175, Jan. 6, 1997.

Buell JF, Reed E, Lee KB, Parker RJ, Venzon DJ, Amikura K, Arnold WS, Fraker DL, Alexander HR. Synergistic effect and possible mechanisms of tumor necrosis factor and cisplatin cytotoxicity under moderate hyperthermia against gastric cancer cells. Ann Surg Onc 4(2):141-148, Mar. 1997.

Vargas HI, Kavoussi LR, Bartlett DL, Wagner JR, Venzon DJ, Fraker DL, Alexander HR, Lindhan WM, Walther MM. Laparoscopic adrenalectomy: a new standard of care. Urology 49(5):673-678, May 1997.

Orel SG, Reynolds C, Schnall MD, Solin LJ, Fraker DL, Sullivan DC. Breast carcinoma: MR Imaging before re-excisional biopsy. Radiology 205(2):429-436, Nov. 1997.

van de Rijn M, Barr FG, Xiang QB, Salhany KE, Fraker DL, Fisher C. Radiation associated synovial sarcoma. Human Pathology 28(11):1325-1328, Nov. 1997.

Bartlett DL, Ma G, Alexander HR, Libutti SK, Fraker DL Isolated limb reperfusion with tumor necrosis factor and melphalan in patients with extremity melanoma after failure of isolated limb perfusion with chemotherapeutics. Cancer 80(11):2084-2090, Dec. 1, 1997.

Wu PC, Alexander HR, Bartlett DL, Doppman JL, Fraker DL, Norton JA, Gibril F, Fogt F, Jensen RT. A prospective analysis of the frequency, location, and curability of ectopic (nonpancreaticoduodenal, nonnodal) gastrinoma. Surgery 122(6):1176-1182, Dec. 1997.

Libutti SK, Bartlett DL, Jaskowiak NT, Skarulis M, Marx SJ, Spiegel AM, Fraker DL, Doppman JL, Shawker TJ, Alexander HR. The role of thyroid resection during reoperation for persistent or recurrent hyperparathyroidism. Surgery 122(6):1183-1188, Dec. 1997.

Brown CK, Bartlett DL, Doppman JL, Gorden P, Libutti SK, Fraker DL, Shawker TH, Skarulis MC, Alexander HR. Intra-arterial calcium stimulation and intraoperative ultrasonography in the localization and resection of insulinomas. Surgery 122(6):1189-1193, Dec. 1997.

Alexander HR, Bartlett DL, Libutti SK, Fraker DL, Moser T, Rosenberg SA. Isolated hepatic perfusion with tumor necrosis factor and melphalan for unresectable cancers confined to the liver. J Clin Oncol 16(4):1479-1489, Apr. 1998.

Sanchez-Ortiz RF, Fraker DL, Malkowicz SB. Renal cell carcinoma presenting with mesenteric thrombosis and anticardiolipin antibodies: Echoes of Trousseau’s Syndrome? J Urology 159(6):2078, June 1998.

Alexander HR, Fraker DL, Norton JA, Bartlett DL, TioL, Benjamin SB, Doppman JL, Goebel SU, Serrano J, Gibril F, Jensen RT. Prospective study of somatostatin receptor scintigraphy and its effect on operative outcome in patients with Zollinger-Ellison syndrome. Ann Surg 228(2):228-238, Aug. 1998.

Kammen BF, Elder D, Fraker DL, Siegelman ES. Extraadrenal myelolipoma: MR imaging findings. Am J Roentgenology 171(3):721-723, Sept. 1998.

Park BJ, Huang J, Royalty D, Libutti SK, Skarulis MC, Jensen RT, Fraker DL, Gorden P, Norton JA, Alexander HR, Bartlett DL. Operative management of islet-cell tumors (ICTS) arising in the head of the pancreas. Surgery 124(6):1056-1062, Dec. 1998.

Norton J, Doherty GM, Fraker DL, Alexander HR, Doppman J, Venzon DJ, Gibril F, Jensen RT. Surgical treatment of localized gastrinoma within the liver: A prospective study. Surgery 124(6):1145-1152, Dec. 1998.

Alexander HR, Bartlett DL, Venzon DT, Libutti SK, Doppman JL, Fraker DL, Norton JA, Gibril F, Jensen RT. Analysis of factors associated with long-term cure in patients undergoing operation and resection for Zollinger-Ellison syndrome (ZES). Surgery 124(6):1160-1166, Dec. 1998.

Lampreave JL, Benard F, Alavi A, Jimenez-Hoyuela J, Fraker DL. Positron emission tomography evaluation of therapeutic limb perfusion in Merkel’s cell carcinoma. J Nucl Med 39(12):2067-2090, Dec. 1998.

Abraham SC, Fox K, Fraker DL, Solin L, Reynolds C. Sampling of grossly benign breast re-excisions: A multidisciplinary approach to assessing adequacy. Am J Surg Pathol 23(3):316-322, Mar. 1999.

Czerniecki BJ, Scheff AM, Callans LS, Spitz FR, Bedrosian I, Conant E, Orel S, Berlin J, Helsabeck C, Fraker DL, Reynolds C. Immunohistochemistry with pancytokeratins improves the sensitivity of sentinel node biopsy in patients with breast cancer. Cancer 85(5):1098-1103, Mar. 1, 1999.

Bedrosian I, Scheff AM, Mick R, Callans LS, Bucky LP, Spitz FR, Helsabeck C, Elder DE, Alavi A, Fraker DL, Czerniecki BJ. Technetium-99m human serum albumin: An effective radiotracer for identifying sentinel lymph nodes in melanoma. Journal of Nuclear Medicine, 40(7):1143-1148, July 1999.

Orel SG, Weinsteinn SP, Schnall MD, Reynolds CA, Schuchter L, Fraker DL, Solin LJ. Breast MR Imaging of patients with axillary node metastases and unknown primary malignancy. Radiology 212(2):543-549, Aug. 1999.

Norton JA, Fraker DL, Alexander HR, Venzon DJ, Doppman JL, Serrano J, Goebel SU, Peghini PL, Roy PK, Gibril F, Jensen RT. Surgery to cure the Zollinger-Ellison Syndrome. NEJM 341(9):635-44, Aug. 26, 1999.

Engbrecht B, Menon C, Kachur A, Hahn S, Fraker DL. Photofrin-mediated photodynamic therapy induces vascular occlusion and apoptosis in a human sarcoma xenograft model. Cancer Research 59(17):4334-4342, Sept. 1, 1999.

Feldman AL, Alexander HR, Bartlett DL, Fraker DL, Libutti SK. Management of extremity recurrences after complete responses to isolated limb perfusion in patients with melanoma. Ann Surg Oncol 6(6):562-567, Sept. 1999.

Desai SS, Loh E, Kochman ML, Fraker DL, DeNofrio D. DeNovo ampullary neuroendocrine tumor in an orthotopic heart transplant recipient. Am J Gastroenterol 94(11):3382-3383, Nov. 1999.

Feldman AL, Sharaf RN, Skarulis MC, Bartlett DL, Libutti SK, Weinstein LS, Marx SJ, Norton JA, Fraker DL, Alexander HRl. Results of heterotropic parathyroid autotransplantation: A 13 year experience. Surgery 126(6):1042-1048, Dec. 1999.

Vulcan TG, Zhu TC, Rodriguez CE, Hsi A, Fraker DL, Baas P, Murrer LH, Star WM, Glatstein E, Yodh AG, Hahn SM. Comparison between isotropic and nonisotropic dosimetry systems during intraperitoneal photodynamic therapy. Lasers in Surgery & Medicine 26(3):292-301, 2000.

Bedrosian I. Faries MB. Guerry D 4th. Elenitsas R. Schuchter L. Mick R. Spitz FR. Bucky LP. Alavi A. Elder DE, Fraker DL, Czerniecki BJ. Incidence of sentinel node metastasis in patients with thin primary melanoma (< or = 1 mm) with vertical growth phase. Ann Surg Oncol 7(4):262-267, May 2000.

Bedrosian I, Reynolds C, Mick R, Callans LS, Grant CS, Donohue JH, Farley DR, Heller R, Conant E, Orel SG, Lawton T, Fraker DL, Czerniecki BJ. Accuracy of sentinel lymph node biopsy in patients with large primary breast tumors. Cancer 88(11):2540-2545, June 1, 2000.

Alexander HR, Libutti SK, Bartlett DL, Puhlmann M, Fraker DL, Bachenheimer LC. A phase I-II study of isolated hepatic perfusion using melphalan with or without tumor necrosis factor for patients with ocular melanoma metastatic to liver. Clin Cancer Research 6(8):3062-3070, Aug. 2000.

Libutti SK, Bartlett DL, Fraker DL, Alexander HR. Technique and results of hyperthermic isolated hepatic perfusion with tumor necrosis factor and melphalan for the treatment of unresectable hepatic malignancies. JACS 191(5):519-530, Nov. 2000.

Hendren SK, Hahn SM, Spitz FR, Bauer TW, Rubin SC, Zhu T, Glatstein E, Fraker DL. Phase II trial of debulking surgery and photodynamic therapy for disseminated intraperitoneal tumors. Ann Surg Oncol 8(1):65-71, Jan./Feb. 2001.

Evans SM, Hahn SM, Magarelli DP, Zhang PJ, Jenkins WT, Fraker DL, Hsi RA, McKenna WG, Koch CJ. Hypoxia in human intraperitoneal and extremity sarcomas. Int J Radia Oncol,Biol Phys 49(2):587-596, Feb. 1, 2001.

Bartlett DL, Libutti SK, Figg WD, Fraker DL, Alexander HR. Isolated hepatic perfusion for unresectable hepatic metastases from colorectal cancer. Surgery 129(2):176-187, Feb. 2001.

Griffin GM, Zhu T, Solonenko M, Del Piero F, Kapakin A, Busch TM, Yodh A, Polin G, Bauer T, Fraker D, Hahn SM. Preclinical evaluation of motexafin lutetium-mediated intraperitoneal photodynamic therapy in a canine model. Clin Cancer Research 7(2):374-381, Feb. 2001.
Research Publications, Peer-Reviewed (cont.):

Bauer TW, Hahn SM, Spitz FR, Kachur A, Glatstein E, Fraker DL. Preliminary report on photo-dynamic therapy for intraperitoneal sarcomatosis. Ann Surg Oncol 8(3):254-259, Apr. 2001.

Chang JH, Vines E, Bertsch H, Fraker DL, Czerniecki BJ, Rosato EF, Lawton T, Conant EF, Orel SG, Schuchter L, Fox KR, Zieber N, Glick JH, Solin LJ. The impact of a multidisciplinary breast cancer center on recommendations for patient management: the University of Pennsylvania experience. Cancer 91(7):1231-1237, Apr 1, 2001.

Tada H, Maron DJ, Choi EA, Barsoum J, Lei H, Xie Q, Liu W, Ellis L, Moscioni AD, Tazelaar J, Fawell S, Qin X, Propert KJ, Davis A, Fraker DL, Wilson JM, Spitz FR. Systemic IFN-beta gene therapy results in long-term survival in mice with established colorectal liver metastases. J Clin Investiga 108(1):83-95, July 2001.

Maron DJ, Tada H, Moscioni AD, Tazelaar J, Fraker DL, Wilson JM, Spitz FR. Intra-arterial delivery of a recombinant adenovirus does not increase gene transfer to tumor cells in a rat model of metastatic colorectal carcinoma. Molec Ther: J Am Soc Gene Ther 4(1):29-35, July 2001.

Mercier GA, Alavi A, Fraker DL. FDG positron emission tomography in isolated limb perfusion therapy in patients with locally advanced melanoma: preliminary results. Clin Nucl Med 26(10):832-836, Oct. 2001.

Norton JA, Alexander HR, Fraker DL, Venzon DJ, Gibril F, Jensen RT. Comparison of surgical results in patients with advanced and limited disease with multiple endocrine neoplasia type 1 and Zollinger-Ellison syndrome. Ann Surg 234(4):495-506, Oct. 2001.

Baloch ZW, Hendreen S, Gupta PK, LiVolsi VA, Mandel SJ, Weber R, Fraker D. Interinstitutional review of thyroid fine-needle aspirations: Impact on clinical management of thyroid nodules. Diagnos Cytopathol 25(4):231-234, Oct. 2001.

Baloch ZW, Fraker D, LiVolsi VA. Parathyromatosis as cause of recurrent secondary hyperparathyroidism: a cytologic diagnosis. Diagnos Cytopathol 25(6):403-405, Dec. 2001.

Kivlen MH, Bartlett DL, Libutti SK, Skarulis MC, Marx SJ, Simonds WF, Weinstein LS, Jensen RT, McCart JA, Naik AM, Kranda KC, Brennan MF, Norton JA, Fraker DL, Alexander HR. Reoperation for hyperparathyroidism in multiple endocrine neoplasia type 1. Surgery 130(6):991-998, Dec. 2001.

Menon C, Kutney SN, Lehr SC, Hendren SK, Busch TM, Hahn SM, Fraker DL. Vascularity and uptake of photosensitizer in small human tumor nodules: Implications for intraperitoneal photodynamic therapy. Clin Cancer Res 7(12):3904-3911, Dec. 2001.

Zogakis TG, Bartlett DL, Libutti SK, Liewehr DJ, Steinberg SM, Fraker DL, Alexander HR. Factors affecting survival after complete response to isolated limb perfusion in patients with in-transit melanoma. Ann Surg Oncol 8(10):771-778, Dec. 2001.

Bauer TW, Spitz FR, Callans LS, Alavi A, Mick R, Weinstein SP, Bedrosian I, Fraker DL, Bauer TL, Czerniecki BJ. Subareolar and peritumoral injection identify similar sentinel nodes for breast cancer. Ann Surg Oncol 9(2):169-176, Mar. 2002.

Prabakaran I, Menon C, Xu S, Gomez-Yafal A, Czerniecki BJ, Fraker DL. Mature CD83(+) dendritic cells infected with recombinant gp100 vaccinia virus stimulate potent antimelanoma T cells. Ann Surg Oncol 9(4):411-418, May 2002.

Bedrosian I, Schlencker J, Spitz FR, Orel SG, Fraker DL, Callans LS, Schnall M, Reynolds C, Czerniecki BJ. Magnetic resonance imaging-guided biopsy of mammographically and clinically occult breast lesions. Ann Surg Oncol 9(5):457-461, June 2002.

Kelley ST, Menon C, Buerk DG, Bauer TW, Fraker DL. Acidosis plus melphalan induces nitric oxide-mediated tumor regression in an isolated limb perfusion human melanoma xenograft model. Surgery 132(2):252-258, Aug. 2002.

Menon C, Iyer M, Prabakaran I, Canter RJ, Lehr SC, Fraker DL. TNF-alpha downregulates vascular endothelial Flk-1 expression in human melanoma xenograft model. Am J Physiol - Heart & Circ Physiol 284(1):H317-329, Jan. 2003.

Bauer TW, Gutierrez M, Dudrick DJ, Li J, Blair IA, Menon C, Fraker DL. A human melanoma xenograft in a nude rat responds to isolated limb perfusion with TNF plus melphalan. Surgery 133(4):420-428, Apr. 2003.

Norton JA, Alexander HR, Fraker DL, Venzon DJ. Gibril F. Jensen RT. Possible primary lymph node gastrinoma: occurrence, natural history, and predictive factors: A prospective study. Ann Surg 237(5):650-659, May 2003.

Canter RJ, Mick R, Kesmodel SB, Raz DJ, Spitz FR, Metz JM, Glatstein EJ, Hahn SM, Fraker DL. Intraperitoneal photodynamic therapy causes a capillary-leak syndrome. Ann Surg Oncol 10(5):514-524, June 2003.

Chu AY, LiVolsi VA, Fraker DL, Zhang PJ. Corticomedullary mixed tumor of the adrenal gland with concurrent adrenal myelolipoma. Arch Pathol Lab Med 127(8):e329-332, Aug. 2003.

Bedrosian I, Mick R, Orel SG, Schnall M, Reynolds C, Spitz FR, Callans LS, Buzby GP, Rosato EF, Fraker DL, Czerniecki BJ. Changes in the surgical management of patients with breast carcinoma based on preoperative magnetic resonance imaging. Cancer 98(3):468-473, Aug. 1, 2003.

Choi EA, Lei H, Maron DJ, Wilson JM, Barsoum J, Fraker DL, El-Deiry WS, Spitz FR. Stat1-dependent induction of tumor necrosis factor-related apoptosis-inducing ligand and the cell-surface death signaling pathway by interferon beta in human cancer cells. Cancer Res 63(17):5299-5307, Sept. 1, 2003.

Menon C, Polin GM, Prabakaran I, Hsi A, Cheung C, Culver JP, Pingpank JF, Sehgal CS, Yodh AG, Buerk DG, Fraker DL. An integrated approach to measuring tumor oxygen status using human melanoma xenografts as a model. Cancer Res 63(21):7232-7240, Nov. 1, 2003.

Kesmodel SB, Terhune KP, Canter RJ, Mandel SJ, LiVolsi VA, Baloch ZW, Fraker DL. The diagnostic dilemma of follicular variant of papillary thyroid carcinoma. Surgery 134(6):1005-1012, Dec. 2003.

Choi EA, Lei H, Maron DJ, Mick R, Barsoum J, Yu QC, Fraker DL, Wilson JM, Spitz FR. Combined 5-fluorouracil/systemic interferon-beta gene therapy results in long-term survival in mice with established colorectal liver metastases. Clin Cancer Res 10(4):1535-1544, Feb. 15, 2004.

Wilson JJ, Jones H, Burock M, Smith D, Fraker DL, Metz J, Glatstein E, Hahn SM. Patterns of recurrence in patients treated with photodynamic therapy for intraperitoneal carcinoma-tosis and sarcomatosis. Interna J Oncol 24(3):711-717, Mar. 2004.

Canter RJ, Zhou R, Kesmodel SB, Zhang Y, Heitjan DF, Glickson JD, Leeper DB, Fraker DL. Metaiodobenzylguanidine and hyperglycemia augment tumor response to isolated limb perfusion in a rodent model of human melanoma. Ann Surg Oncol 11(3):265-273, Mar. 2004.

Hendren SK, Prabakaran I, Buerk DG, Karakousis G, Feldman M, Spitz F, Menon C, Fraker DL. Interferon-beta gene therapy improves survival in an immunocompetent mouse model of carcinomatosis. Surgery 135(4):427-436, Apr. 2004.

Norton JA, Alexander HR, Fraker DL, Venzon DJ, Gibril F, Jensen RT. Does the use of routine duodenotomy (DUODX) affect rate of cure, development of liver metastases, or survival in patients with Zollinger-Ellison syndrome? Ann Surg 239(5):617-626, May 2004.

Shah JN, Fraker D, Guerry D, Feldman M, Kochman ML. Melanoma seeding of an EUS-guided fine needle track. Gastrointes Endosc 59(7):923-92, June 2004.

Busch TM, Hahn SM, Wileyto EP, Koch CJ, Fraker DL, Zhang P, Putt M, Gleason K, Shin DB, Emanuele MJ, Jenkins K, Glatstein E, Evans SM. Hypoxia and Photofrin uptake in the intraperitoneal carcinomatosis and sarcomatosis of photodynamic therapy patients. Clin Cancer Res 10(14):4630-4638, July 15, 2004.

Augoustides JG, Abrams M, Berkowitz D, Fraker D. Vasopressin for hemodynamic rescue in catecholamine-resistant vasoplegic shock after resection of massive pheochromocytoma. Anesthesiology 101(4):1022-1024, Oct. 2004.

Carr CE, Cope C, Cohen DL, Fraker DL, Trerotola SO. Comparison of sequential versus simultaneous methods of adrenal venous sampling. J Vasc Interven Radiol 15(11):1245-1250, Nov. 2004.

Giorgadze TA, Roy S, Fraker DL, Brooks JS, Livolsi VA. Pathologic quiz case: A 49-year-old woman with an adrenal mass: Pancreatic tissue with nesidiodysplasia, adrenocortical adenoma, and ovarian thecal metaplasia in the adrenal gland. Archives Pathol Lab Med 128(11):1294-1296, Nov. 2004.

Kelz RR, Gimotty PA, Polsky D, Norman S, Fraker D, DeMichele A. Morbidity and mortality of colorectal carcinoma surgery differs by insurance status. Cancer 101(10):2187-2194, Nov. 15, 2004.

Downes KJ, Glatt BS, Kanchwala SK, Mick R, Fraker DL, Fox KR, Solin LJ, Bucky LP, Czerniecki BJ. Skin-sparing mastectomy and immediate reconstruction is an acceptable treatment option for patients with high-risk breast carcinoma. Cancer 103(5):906-913, Mar. 1, 2005.

Choe R, Corlu A, Lee K, Durduran T, Konecky SD, Grosicka-Koptyra M, Arridge SR, Czerniecki BJ, Fraker DL, DeMichele A, Chance B, Rosen MA, Yodh AG. Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: A case study with comparison to MRI. Med Physics 32(4):1128-1139, Apr. 2005.

Kesmodel S, Prabakaran I, Canter R, Menon C, Molnar-Kimber K, Fraker D. Virus-mediated oncolysis of thyroid cancer by a replication-selective adenovirus driven by a thyroglobulin promoter-enhancer region. J Clin Endocrinol Metab 90(6):3440-3448, June 2005.

Kesmodel SB, Karakousis GC, Botbyl JD, Canter RJ, Lewis RT, Wahl PM, Terhune KP, Alavi A, Elder DE, Ming ME, Guerry D, Gimotty PA, Fraker DL, Czerniecki BJ, Spitz FR. Mitotic rate as a predictor of sentinel lymph node positivity in patients with thin melanomas. Ann Surg Oncol 12(6):449-458, June 2005.

Reviews in Peer Reviewed Research Publications

Fraker DL and Norton JA. The role of surgery in the management of islet cell tumors. [Review] Gastroenterology Clin. of N. Am. 18(4):805-830, Dec. 1989.

Norton JA and Fraker DL. Tolerance to tumor necrosis factor. [Review] Nutrition 5(2):131-135, Mar./Apr. 1989.

Alexander HR, Grem J, Pass HI, Hamilton M, McAtee N, Fraker DL, Allegra C. Neoadjuvant chemotherapy for locally advanced gastric adenocarcinoma. [Review] Oncology 7(5):37-42, May 1993.

Fraker DL, Norton JA. Controversies in surgical therapy for apudomas. [Review] Semin Surg Oncol 9(5):437-442, Sept. 1993.

Fraker DL, Alexander HR. The use of tumour necrosis factor (TNF) in isolated perfusion: Results and side effects: The NCI results. [Review] Melanoma Research 4 Suppl. 1:27-29, Mar. 1994.

Fraker DL, Alexander HR, Thom AK. Use of tumor necrosis factor in isolated hepatic infusion. [Review] Circulatory Shock 44(1):45-50, Sept. 1994.

Alexander HR, Billingsley KG, Block MI, Fraker DL. D-Factor/Leukemia inhibitory factor: Evidence for its role as a mediator of acute and chronic inflammatory disease. [Review] Cytokine 6(6):589-596, Nov. 1994.

Arnold WS, Fraker DL, Alexander HR, Weber HC, Norton JA, Jensen RT. Apparent lymph node primary gastrinoma. [Review] Surgery 116(6):1123-1130, Dec. 1994.

Yang JC, Fraker DL, Thom AK, Pass HI, Rosenberg SA. Isolation perfusion with tumor necrosis factor-alpha, interferon-gamma, and hyperthermia in the treatment of localized and metastatic cancer. [Review] Recent Results in Cancer Research 138:161-166, 1995.

Fraker DL and Alexander HR. The surgical approach to endocrine tumors of the pancreas. Semin Gastrointest Dis 6(2):102-113, Apr. 1995.

Fraker DL. Radiation exposure and other factors that predispose to human thyroid neoplasia. [Review] Surg Clin N Am 75(3): 365-375, June 1995.

Alexander HR, Fraker DL. Continuous hyperthermic peritoneal perfusion with cisplatin in the treatment of peritoneal carcinomatosis. [Review] Canc Treat & Research 81:41-50, 1996.

Alexander HR, Fraker DL, Bartlett DL. Isolated limb perfusion for malignant melanoma. [Review] Sem Surg Oncol 12(6):416-428, Nov./Dec. 1996.

Fraker DL. Surgical issues in the management of melanoma. [Review] Curr Opin Oncol 9(2):183-188, Mar. 1997.

Fraker DL. Hyperthermic regional perfusion for melanoma and sarcoma of the limbs. [Review] Curr Problems Surg 36(11):841-908, Nov. 1999.

Fraker DL. Update on management of parathyroid tumors. {Review] Curr Opin Oncol 12(1):41-48, Jan. 2000.

Schuchter LM, Green R, Fraker D. Primary and metastatic diseases in malignant melanoma of the gastrointestinal tract. [Review] Curr Opin Oncol 12(2):181-5, Mar. 2000.

Fraker DL, Soulen M. Regional therapy of hepatic metastases. [Review] Hematol Oncol Clin NA 16(4):947-967, Aug. 2002.

Fraker DL. Management of in-transit melanoma of the extremity with isolated limb perfusion. [Review] Curr Treat Options in Oncol 5(3):173-184, June 2004.

Menon C, Fraker DL. Tumor oxygenation status as a prognostic marker. [Review] Cancer Letters 221(2):225-235, Apr. 28, 2005.

Research Publications, Non-Peer-Reviewed

Auerbach RA, Fraker DL and Sidky YA. Regional differences in tumor growth in mice. Fortschr. Zoology 26:133, 1981.

Fraker DL and Norton JA Reversal of the toxic effects of cachectin by insulin. Surg Forum 38:18-20, 1987.

Fraker DL and Norton JA TNF and endotoxin: cross-tolerance by different mechanisms. Surg Forum 39:15-18, 1988.

Evans S, Matthews W, Perry R, Fraker DL, Norton JA and Pass HI. Photodynamic therapy stimulates murine peritoneal macrophages to produce tumor necrosis factor. Surg Forum 40: 421-423, 1989.

Langstein HN, Fraker DL and Norton JA. Reversal of cancer cachexia by antibodies to interferon-gamma but not cachectin/tumor necrosis factor. Surg Forum 40:408-410, 1989.

Jensen JC, Buresh CM, Fraker DL, Langstein HL, Doherty GM, Alexander HR and Norton JA. Enhanced cytokine gene expression in cachectic tumor bearing rats. Surg Forum 41, 1990.

Block MI, Arnold WS, Fraker DL, Alexander HR. D-Factor mediates IL-6 but not IL-1 production following TNF administration in vivo. Surg Forum 44:95-96, 1993.

Brundage SI, Block MI, Billingsley KG, Fraker DL, Alexander HR. Role of leukemia inhibitory factor (LIF) in experimental sepsis. Surg Forum 45:1-3, 1994.

Arnold WS, Tannenbaum SH, Yu KC, Alexander HR, Fraker DL. Effects of human fibrosarcoma tumor supernatant on endothelial cells(EC): Induction of tissue factor (TF) expression and augmented expression of adhesion molecules in response to tumor necrosis factor (TNF) Surg Forum 45:548-550, 1994.

Billingsley KG, Strassmann G, Arnold WS, Fraker DL, Alexander HR. Monocytes augment production of interleukin-6 (IL-6) and leukemia inhibitory factor (LIF) by human tumor cell lines. Surg Forum 45:471-474, 1994.

Fraker DL. Commentary on "Percutaneous Radiofrequency Interstitial Thermal Ablation in the Treatment of Small Hepatocellular Carcinoma: Report of 24 Patients". The Cancer Journal 1:30-31, 1995.

Yang JC, Fraker DL, Thom AK, Pass HI, Rosenberg SA. Isolation perfusion with tumor necrosis factor-A, interferon-B and hyperthermia in the treatment of localized and metastatic cancer. Recent Results Cancer Res. 138:161-166, 1995.

Fraker DL, Alexander HR. Use of high-dose tumor necrosis factor in isolation perfusion of the limbs and liver. Reg Canc Treat 1996.

Fraker DL, Norton JA. Pancreatic islet cell tumor - Insulinoma: Discussion of a case presentation. Postgraduate General Surgery 1996.

Ma G, Turner E, Jaskowiak N, Sarraf P, Bartlett D, Fraker DL, Alexander HR. Obese gene expression is acutely regulated by tumor necrosis factor during sublethal endotoxemia in mice. Surg Forum 47:17-20, 1996.

Fraker DL. Isolated limb perfusion: A Case Study. Melanoma Newsletter 1997.

Pingpank JF, Fraker DL. An in vivo model demonstrating that tumor necrosis factor targets tumor endothelium. Surg Forum 48:804-806, 1997.

Iyer M, Prabakaran I, Menon C, Fraker DL. Tumor necrosis factor downregulates vascular endothelial growth factor receptor Flk-1 in vivo. Surg Forum 50:311-313, 1999.

Mulvany KP, Prabakaran I, Xu S, Khorrami C, Menon C, Czerniecki B, Fraker DL, Callans LS. Human monocyte-derived dendritic cells transduced with recombinant adenovirus present melanoma antigen gp100 to cytotoxic T lymphocytes in vitro. Surg Forum 50:309-310, 1999.

Editorials, Chapters & Participation in Committee Reports

Norton JA and Fraker DL. Malignant neoplasms: The role of specific serum tests in the diagnosis, management, and evaluation of recurrence. In: Textbook of Surgery: Update 2; Ed. Sabiston DC. Philadelphia: W.B. Saunders, 19-37, 1989.

Fraker DL. Blood gases and acid-base disorders, In: Clinicians Pocket Reference, 6th Edition; Ed. Gomella LG. Norwalk, CT: Appleton & Lange, 127-134, 1989.

Fraker DL. Fluids and electrolytes, In: Clinicians Pocket Reference. 6th Edition; Ed. Gomella LG. Norwalk, CT: Appleton & Lange, 127-134, 1989.

Norton JA and Fraker DL. Tumor markers. In: Textbook of Surgery: The Biological Basis of Modern Surgical Practice, 14th Edition; Ed. Sabiston, D.C. Philadelphia: W.B. Saunders, 491-509, 1991.

Norton JA and Fraker DL. Tumor markers. In: The Essentials of Surgery, 2nd Edition; Ed. Sabiston DC. Philadelphia: W.B. Sanders, 237-245, 1991.

Norton JA, Shawker TH, Doppman JL, Miller DL, Fraker DL, Romack DT, Gorden P, Jensen RT. Letter to Editor. Ann Surg 215:87-88, 1992.

Fraker DL, Alexander HR, Norton JA. Biologic therapy of sepsis: The role of antibodies to endotoxin and tumor necrosis factor, and the interleukin-1 receptor antagonist. In: Biologic Therapy of Cancer, Principles and Practice. PPO Updates; Eds. DeVita VT Jr, Hellman S, Rosenberg SA. Philadelphia: Lippincott, 2: 1-13, 1992.

Norton JA and Fraker DL. Tumor markers. Textbook of Surgery: Pocket Companion; Eds. Sabiston DC, Lyerly HK. Philadelphia: W.B. Saunders, 232-242, 1992.

Fraker DL, contributor. Obstetrics and Gynecology on Call; Eds: Horowitz IR, Gomella AT. Norwalk, CT: Appleton & Lange, 1993.*

Norton JA, Doherty GM, Fraker DL. Surgery for endocrine tumors of the pancreas. In: The Pancreas: Biology, Pathobiology and Disease, 2nd Edition; Ed. VLW Go. New York: Raven Press, 1009-1027, 1993.

Fraker DL, Alexander HR. The use of tumor necrosis factor in isolated limb perfusions for melanoma and sarcoma. In: Principle and Practice of Oncology. PPO Updates; Eds. DeVita V, Hellman S, Rosenberg S. Philadelphia: J.B. Lippincott, 7:1-10, 1993.

Fraker DL, Norton JA. The role of tumor necrosis factor in the toxicity and the antineoplastic activity of interleukin-2 immunotherapy. In: Tumor Necrosis Factor: Molecular and Cellular Biology and Clinical Relevance. Basal Karger, 221-225, 1993.

Wertheimer BM and Fraker DL. Cause of hypotension after isolated limb perfusion with tumor necrosis factor. Letter. Anesthesiology 80(4):961-962, Apr.1994.

Fraker DL, Alexander HR. Isolated limb perfusion with high-dose tumor necrosis factor for extremity melanoma and sarcoma. In: Important Advances in Oncology; Eds. DeVita V, Hellman S, Rosenberg SA. Philadelphia: Lippincott, 179-192, 1994.

Fraker DL, Alexander HR, Pass HI. Biologic therapy with tumor necrosis factor: Clinical applications by systemic and regional administration. In: Biologic Therapy of Cancer, 2nd Edition; Eds. DeVita V, Hellman S, Rosenberg SA. Philadelphia: Lippincott, 329-346, 1995.

Fraker DL, Norton JA. Endocrine Pancreas. In: Clinical Surgery, 2nd Edition; Ed. Davis J. St. Louis: Mosby, 2398-2421, 1995.

Alexander HR, Buell JF, Fraker DL. Rationale and clinical status of continuous hyperthermic peritoneal perfusion (CHPP) for the treatment of peritoneal carcinomatosis. In: Principal and Practice of Oncology. PPO Updates; Eds. DeVita V, Hellman S, Rosenberg S. Philadelphia: J.B. Lippincott, 9:1-9, 1995.

Fraker DL. Book review of "Cancer Surgery," Eds. McKenna RJ and Murphy GP. Lippincott, Philadelphia, PA. Oncology 9:410, 1995.

Alexander HR, Fraker DL. Treatment of peritoneal carcinomatosis by continuous hyperthermic peritoneal perfusion with cisplatin. Cancer Treatment & Research 81:41-50, 1996.

Fraker DL, Skarulis M, LiVolsi, V. Thyroid cancer. In: Cancer: Principles and Practice of Oncology, 5th Edition; Eds. DeVita V, Rosenberg SA, Hellman S. Philadelphia: JB Lippincott Co., 1629-1651, 1996

Fraker DL. Parathyroid cancer. In: Cancer: Principles and Practice of Oncology, 5th Edition; Eds. DeVita V, Rosenberg SA, Hellman S. Philadelphia: JB Lippincott Co., 1652-1658, 1996.

Fraker DL, Jensen RT. Pancreatic endocrine tumors. In: Cancer: Principles and Practice of Oncology, 5th Edition; Eds. DeVita V, Rosenberg SA, Hellman S. Philadelphia: JB Lippincott Co., 1678-1703, 1996.

Alexander HR, Fraker DL. Treatment of peritoneal carcinomatosis by continuous hyperthermic peritoneal perfusion with cisplatin. In: Peritoneal Carcinomatosis: Drugs and Disease; Ed. Sugarbaker P. Boston: Kluwer Academic Publishers, 41-50, 1996.

Fraker DL. Factors which predispose to thyroid neoplasia, In: Textbook of Endocrine Surgery; Eds. Clark OH, Duh QY, Siperstein A. Philadelphia: W.B. Saunders, 190-197, 1997.

Fraker DL, Alexander HR. Isolated perfusion of the liver. In: Regional Therapy of Advanced Cancer; Eds. Lotze MT, Rubin JT. Philadelphia: Lippincott-Raven, 141-150, 1997.

Alexander HR, Fraker DL. Shunting procedures for malignant ascites and pleural effusions. In: Regional Therapy of Advanced Cancer; Eds. Lotze MT, Rubin JR. Philadelphia: Lippincott-Raven,271-280, 1997.

Fraker DL, Coit D. Isolated perfusion of extremity tumors. In: Regional Therapy of Advanced Cancer; Eds. Lotze MT, Rubin JR. Philadelphia: Lippincott-Raven, 333-349, 1997.

Norton JA, Fraker DL. Tumor markers. In: Textbook of Surgery: The Biological Basis of Modern Surgical Practice, 15th Edition; Ed: Sabiston DC. Philadelphia: WB Saunders, 1997, 534-553.

Norton JA and Fraker DL. Tumor markers. In:Textbook of Surgery: Pocket Companion, 2nd Edition. Eds. Sabiston DC, Lyerly HK. Philadelphia: WB Saunders, 1997, 115-120.

Fraker DL. Hyperthermic Regional Perfusion for Melanoma of the Limbs. In: Cutaneous Melanoma, 3rd Edition; Eds. Balch CM, Houghton AN, Sober AT, Soong SJ. St. Louis: Quality Medical Pub., 281-300, 1998.

Fraker DL, Skarulis M. Thyroid and parathyroid cancer. In: Integrated Cancer Management; Ed. Torosian MH. New York: Marcel Dekker, Inc, 322-344, 2000.

Schuchter LM, Haluska F, Fraker DL, Elenitsas R. Skin: Malignant melanoma. In: Clinical Oncology; Eds. Abeloff MD, Armitage JO, Lichter AS, Niederhuber JE. New York: Churchill Livingstone, 1317-1350, 2000.

Fraker DL, Skarulis M, Livolsi V. Thyroid cancer. In: Cancer: Principles and Practice of Oncology, 6th Edition. Eds. DeVita V, Rosenberg SA, Hellman S. Philadelphia: JB Lippincott Co., 2001, 1740-1762.

Fraker DL. Parathyroid cancer. In: Cancer: Principles and Practice of Oncology, 6th Edition. Eds. DeVita V, Rosenberg SA, Hellman S. Philadelphia: JB Lippincott Co., 2001, 1763-1769.

Fraker DL. Regional therapies of cancer. In: Surgery: Scientific Basis and Current Practice. Eds. Norton, Bollinger, Chang, Lowry, Mulvihill, Pass, Thompson. New York: Springer-Verlag, 2001, 1863-1880.

Fraker DL. Diagnostic testing and clinical decision making. In: Surgical Endocrinology. Eds. Doherty GM, Skogseid. Philadelphia: Lippincott/Williams & Wilkins, 2001, 3-6.

Fraker DL. Radiofrequency ablation of colorectal metastases to the liver. In: Multimodality Management. Ed. Saltz L. Totowa, NJ: Humana Press, 2002, 437-454.

Doherty GM, Fraker DL, Hohn DC. Spleen. In: Current Surgical Diagnosis and Treatment, 11th Edition. Eds. Way LW, Doherty GM. New York: Lange/McGraw-Hill, 2003, 652-667.

Fraker DL. Hyperthyroidism: Medical and surgical management. In: Endocrine Surgery of the Head and Neck. Eds. Pellitieri P, McCaffrey. Clifton Park, NY: Delmar, 2003, 235-252.

Fraker DL, Eggermont, AE.- Hyperthermic regional perfusion for melanoma of the limbs. In: Cutaneous Melanoma, 4th Edition. Eds. Balch CM, Houghton AN, Sober AT, Soong SJ. St. Louis: Quality Medical Publishing, 2003, 473-494.

Fraker DL. Combination of radiofrequency ablation and intra-arterial chemotherapy for metastatic cancer in the liver. In: Radiofrequency Ablation for Cancer. Eds. Ellis LM, Curley SA, Tanabe KK. New York: Springer-Verlag, 2004, 47-66.

Fraker DL. Parathyroid cancer. In: Cancer: Principles and Practice of Oncology, 7th Edition. Eds. DeVita V, Rosenberg SA, Hellman S. Philadelphia: Lippincott/Williams & Wilkins, 2005, 1521-1528.

Rapaport-Kelz, Fraker DL. Factors which predispose to thyroid neoplasia. In: Textbook of Endocrine Surgery, 2nd Edition. Eds. Clark OH, Duh QY, Siperstein A. Philadelphia: Saunders/Elsevier, 2005, 240-247.

Fraker DL. The spleen. In: Surgery: Scientific Principles and Practice, 3rd Edition. Ed. Greenfield L. Philadelphia: Lippincott Williams & Wilkins, 2005 (in press).

Doherty GM, Fraker DL. Spleen. In: Current Surgical Diagnosis and Treatment, 12th Edition. Eds. Way LW, Doherty GM. New York: Lange/Mcgraw-Hill, 2005 (in press).

Books

Gomella LG, Lefor AT (Eds.); Fraker DL, Wiebke EA (Assoc. Eds.) Surgery on Call. Norwalk, CT: Appleton & Lange, 1990.

Gomella LG, Lefor AT (Eds.); Fraker DL, Wiebke EA (Assoc. Eds.) Surgery on Call, 2nd Edition. Norwalk, CT: Appleton & Lange, 1996.

Gomella LG (Ed.); Fraker DL (Assoc. Ed.) Clinician's Pocket Reference, 8th Edition. Norwalk, CT: Appleton & Lange, 1997.

Haist SA, Robbins JB, Gomella LG (Eds.); Fraker DL, Contributor. Internal Medicine On Call, Second Edition. Norwalk, CT: Appleton & Lange, 1997.

Gomella LG, Lefor AT (Eds.); Fraker DL, Wiebke E.A (Assoc. Eds.). Surgery on Call, 3rd Edition. Norwalk, CT: Appleton & Lange, 2001.