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Holly L. Hedrick, MD, FAAP, FACS
Pediatric Surgery
 
Research Publications, Peer-Reviewed

Schnitzer JJ, Hedrick HL, Pacheco BA, Losty PD, Ryan DP, Doody DP, Donahoe PK. Prenatal glucocorticoid therapy reverses pulmonary immaturity in congenital diaphragmatic hernia in fetal sheep. Annals of Surgery 224(4):430-439, Oct. 1996.

Schnitzer JJ, Thompson JE, Hedrick HL, Kaban JM, Wilson JM. High frequency intratracheal pulmonary ventilation: improved gas exchange at lower airway pressures. Journal of Pediatric Surgery 32(2):203-206, Feb. 1997.

Hedrick HL, Kaban JM, Pacheco BA, Losty PD, Doody DP, Ryan DP, Manganaro TF, Donahoe PK, Schnitzer JJ. Prenatal glucocorticoids improve pulmonary morphometrics in fetal sheep with congenital diaphragmatic hernia. Journal of Pediatric Surgery 32(2):217-222, Feb. 1997.

Schnitzer JJ, Thompson JE, Hedrick HL. A new ventilator improves CO2 removal in newborn lambs with congenital diaphragmatic hernia. Critical Care Medicine 27(1):109-112, Jan. 1999.

Nance ML, Adamson WT, Hedrick HL. Appendicitis in the young child: A continuing diagnostic challenge. Pediatric Emergency Care 16(3):160-162, June 2000.

McElhinney DB, Hedrick HL, Bush DM, Pereira GR, Stafford PW, Gaynor JW, Spray TL, Wernovsky G. Necrotizing enterocolitis in neonates with congenital heart disease: Risk factors and outcomes. Pediatrics 106(5):1080-1087, Nov. 2000.

Hedrick HL, Nelson RM. Handling ethical conflicts in the clinical setting. Seminars in Pediatric Surgery 10(4):192-197, Nov. 2001.

Crombleholme TM, Coleman B, Hedrick H, Liechty K, Howell L, Flake AW, Johnson M, Adzick NS. Cystic adenomatoid malformation volume ratio predicts outcome in prenatally diagnosed cystic adenomatoid malformation of the lung. Journal of Pediatric Surgery 37(3):331-338, Mar. 2002.

Davey MG, Hedrick HL, Mendoza JM, Kanai M, Adzick NS, Flake AW. Pulmonary epithelial liquid absorption, expressed in relation to alveolar surface area, is reduced in fetal lambs following in utero tracheal occlusion. Pediatric Pulmonology 34(4):278-286, Oct. 2002.

Davey MG, Hedrick HL, Bouchard S, Mendoza JM, Schwarz U, Adzick NS, Flake AW. Temporary tracheal occlusion in fetal sheep with lung hypoplasia does not improve postnatal lung function. Journal of Applied Physiology 94(3):1054-62, Mar. 2003.

Davey MG, Hedrick HL, Bouchard S, Adzick NS, Flake AW, Doolin EJ. Computer-assisted stereology: Point fraction of lung parenchyma and alveolar surface density in fetal and newborn sheep. Scanning 25(1):37-44, Jan./Feb. 2003.

Keswani SG, Johnson MP, Adzick NS, Hori S, Howell LJ, Wilson RD, Hedrick H, Flake AW, Crombleholme TM. In utero limb salvage: Fetoscopic release of amniotic bands for threatened limb amputation. Journal of Pediatric Surgery 38(6):848-851, June 2003.

Lim FY, Crombleholme TM, Hedrick HL, Flake AW, Johnson MP, Howell LJ, Adzick NS. Congenital high airway obstruction syndrome: Natural history and management. Journal of Pediatric Surgery 38(6):940-945, June 2003.

Hedrick HL. Ex utero intrapartum therapy. Seminars in Pediatric Surgery 12(3):190-195, Aug. 2003.

Johnson MP, Sutton LN, Rintoul N, Crombleholme TM, Flake AW, Howell LJ, Hedrick HL, Wilson RD, Adzick NS. Fetal myelomeningocele repair: Short-term clinical outcomes. American Journal of Obstetrics & Gynecology 189(2):482-487, Aug. 2003.

Wilson RD, Johnson MP, Crombleholme TM, Flake AW, Hedrick HL, King M, Howell LJ, Adzick NS. Chorioamniotic membrane separation following open fetal surgery: Pregnancy outcome. Fetal Diagnosis & Therapy 18(5):314-320, Sept./Oct. 2003.

Hedrick HL, Crombleholme TM, Flake AW, Nance ML, von Allmen D, Howell LJ, Johnson MP, Wilson RD, Adzick NS. Right congenital diaphragmatic hernia: Prenatal assessment and outcome. Journal of Pediatric Surgery 39(3):319-323, Mar. 2004.

Hedrick HL, Flake AW, Crombleholme TM, Howell LJ, Johnson MP, Wilson RD, Adzick NS. Sacrococcygeal teratoma: Prenatal assessment, fetal intervention, and outcome. Journal of Pediatric Surgery 39(3):430-438, Mar. 2004.

Wilson RD, Baxter JK, Johnson MP, King M, Kasperski S, Crombleholme TM, Flake AW, Hedrick HL, Howell LJ, Adzick NS. Thoracoamniotic shunts: Fetal treatment of pleural effusions and congenital cystic adenomatoid malformations. Fetal Diagnosis & Therapy 19(5):413-420, Sept./Oct. 2004.

Wilson RD, Johnson MP, Flake AW, Crombleholme TM, Hedrick HL, Wilson J, Adzick NS. Reproductive outcomes after pregnancy complicated by maternal-fetal surgery. American Journal of Obstetrics & Gynecology 191(4):1430-1436, Oct. 2004.

Danzer E, Johnson MP, Wilson RD, Flake AW, Hedrick HL, Sutton LN, Adzick NS. Fetal head biometry following in-utero repair of myelomeningocele. Ultrasound in Obstetrics & Gynecology 24(6):606-611, Nov. 2004.

Keswani SG, Crombleholme TM, Pawel BR, Johnson MP, Flake AW, Hedrick HL, Howell LJ, Wilson RD, Davis GH, Adzick NS. Prenatal diagnosis and management of mainstem bronchial atresia. Fetal Diagnosis & Therapy 20(1):74-78, Jan./Feb. 2005.

Davey MG, Biard JM, Robinson L, Tsai J, Schwarz U, Danzer E, Adzick NS, Flake AW, Hedrick HL. Surfactant protein expression is increased in the ipsilateral but not contralateral lungs of fetal sheep with left-sided diaphragmatic hernia. Pediatric Pulmonology 39(4):359-367, Apr. 2005.

Hedrick HL, Flake AW, Crombleholme TM, Howell LJ, Johnson MP, Wilson RD, Adzick NS. The ex utero intrapartum therapy procedure for high-risk fetal lung lesions. Journal of Pediatric Surgery 40(6):1038-1044, June 2005.

Keswani SG, Crombleholme TM, Tychik J, Tian Z, Mackenzie TC, Johnson MP, Wilson RD, Flake AW, Hedrick HL, Howell LJ, Adzick NS. Impact of continuous intraoperative monitoring on outcomes in open fetal surgery. Fetal Diagnosis & Therapy 20(4):316-320, July/Aug. 2005.

DeMatos V, Russo P, Hedrick H, Piccoli D, Mamula P. A 2 year old girl with persistent ascites. Medscape case report, Aug. 2005.

Jackson MB, Guttenberg M, Hedrick H, Moshang T. Multiple endocrine neoplasia type 2A in a kindred with C634Y mutation. Pediatrics 116(3):e468-71, Sept. 2005.

Biard JM, Johnson MP, Carr MC, Wilson RD, Hedrick HL, Pavlock C, Adzick NS. Long-term outcomes in children treated by prenatal vesicoamniotic shunting for lower urinary tract obstruction. Obstetrics & Gynecology 106(3):503-508, Sept. 2005.

Liechty KW, Hedrick HL, Hubbard AM, Johnson MP, Wilson RD, Ruchelli ED, Howell LJ, Crombleholme TM, Flake AW, Adzick NS. Severe pulmonary hypoplasia associated with giant cervical teratomas. Journal of Pediatric Surgery 41(1):230-233, Jan. 2006.

Danzer E, Robinson LE, Davey MG, Schwarz U, Volpe MA, Adzick NS, Flake AW, Hedrick HL. Tracheal occlusion in fetal rats alters expression of mesenchymal nuclear transcription factors without affecting surfactant protein expression. Journal of Pediatric Surgery 2006 (in press).

Danzer E, Hubbard AM, Hedrick HL, Johnson MP, Wilson RD, Howell LJ, Flake AW, Adzick NS. Diagnosis and characterization of fetal sacrococcygeal teratoma with prenatal MR imaging. American Journal of Roentgenology 2006 (in press).

Reviews in Peer Reviewed Research Publications
MacKenzie TC, Crombleholme TM, Johnson MP, Schnaufer L, Flake AW, Hedrick HL, Howell LN, Adzick NS. The natural history of prenatally diagnosed conjoined twins. [Review] Journal of Pediatric Surgery 37(3):303-309, Mar. 2002.

Hedrick HL, Flake AW, Crombleholme TM, Howell LJ, Johnson MP, Wilson RD, Adzick NS. History of fetal diagnosis and therapy: Children's Hospital of Philadelphia experience. [Review] Fetal Diagnosis & Therapy 18(2):65-82, Mar./Apr. 2003.

Biard JM, Wilson RD, Johnson MP, Hedrick HL, Schwarz U, Flake AW, Crombleholme TM, Adzick NS. Prenatally diagnosed giant omphaloceles: Short- and long-term outcomes. [Review] Prenatal Diagnosis 24(6):434-439, June 2004.

Rychik J, Tian Z, Cohen MS, Ewing SG, Cohen D, Howell LJ, Wilson RD, Johnson MP, Hedrick HL, Flake AW, Crombleholme TM, Adzick NS. Acute cardiovascular effects of fetal surgery in the human. [Review] Circulation 110(12):1549-1556, Sept. 21, 2004.

Research Publications, Non-Peer-Reviewed
Hedrick HL, Pacheco BA, Losty PD, Donahoe PK, Schnitzer JJ. Dexamethasone increases expression of surfactant associated protein mRNA in rats with nitrofen-induced congential diaphragmatic hernia. Surgical Forum 66:654-657, 1995.

Hedrick HL, Kaufman OE, Teixeira JM, Donahoe PK, Schnitzer JJ. Analysis of gene expression in scarless fetal vs. postnatal skin. Surgical Forum 67:670-673, 1996.

 


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