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Drebin
JA, Perry LL, Carter R, Greene MI. Regulation of
the immune response to antigens on the malignant cell surface.
Seminars in Immunopathology 5(2):75-192, 1982.
Lowy A, Drebin
JA, Monroe JG, Granstein RD, Greene MI. Genetically
restricted antigen presentation for immunologic tolerance
and suppression. Nature 308(5957):373-375, Mar. 22-28, 1984.
Drebin JA,
Schatten S, Greene MI. The role of antigen presenting cells
in regulating the im-mune response to tumor antigens. Transplantation
Proceedings 16(5):1377-1379, Oct. 1984.
Schechter AL, Stern DF,
Vaidyanathan L, Decker SJ, Drebin JA, Greene
MI, Weinberg RA. The neu oncogene: An erbB related oncogene
that encodes a 185,000 Mr tumor antigen. Nature 312(5994):513-516,
Dec. 6-12, 1984.
Drebin JA,
Stern DF, Link VC, Weinberg RA, Greene MI. Monoclonal antibodies
identify a cell surface antigen associated with an activated
cellular oncogene. Nature 312(5994):545-548, Dec. 6-12, 1984.
Drebin JA,
Link VC, Stern DF, Weinberg RA, Greene MI. Down-modulation
of an oncogene protein product and reversion of the transformed
phenotype by monoclonal antibodies. Cell 41(3):695-706, July
1985.
Drebin JA,
Link VC, Weinberg RA, Greene MI. Inhibition of tumor growth
by a monoclonal antibody reactive with an oncogene-encoded
tumor antigen. Proceedings of the National Academy of Sciences
(USA) 83(23):9129-9133, Dec. 1986.
Drebin JA,
Link VC, Greene MI. Monoclonal antibodies reactive with distinct
domains of the neu oncogene-encoded p185 molecule exert synergistic
anti-tumor effects in vivo. Oncogene 2(3):273-277, Mar. 1988.
Drebin JA,
Hartzell SW, Griffen C, Campbell MJ, Niederhuber JE. Molecular
cloning and chromosomal localization of the human homologue
of a B lymphocyte-specific protein tyrosine kinase gene, blk.
Oncogene 10(3):477-486, Feb. 2, 1995.
Katsumata M, Okudaira T,
Clark D, Drebin JA, Jolicoeur P, Greene MI.
Prevention of breast tumour development in vivo by downregulation
of the p185neu receptor. Nature Medicine 1(7):644-648, July
1995.
Strasberg SM, Drebin
JA, Soper NJ. Evolution and current status of the
Whipple procedure. Gastroenterology 113(3):983-994, Sept.
1997.
Roh H, Boswell C, Hirose
C, Pippin J, Drebin JA. Synergistic anti-tumor
effects of HER2/neu antisense oligodeoxynucleotides and conventional
chemotherapeutic agents. Surgery 126(2):413-421, Aug. 1999.
Strasberg SM, Middleton
WD, Teefey SA, McNevin MS, Drebin JA. Management
of diagnostic dilemmas of the pancreas by ultrasound-guided
laparoscopic biopsy. Surgery 126(4):736-743, Oct. 1999.
Roh H, Pippin J, Drebin
JA. Down-regulation of HER2/neu expression induces
apoptosis in human cancer cells that overexpress HER2/neu.
Cancer Research 60(3):650-655, Feb. 1, 2000.
Green DW, Roh H, Pippin
JA, Drebin JA. Antisense oligonucleotides:
an evolving technology for the modulation of gene expression
in human disease. Journal of the American College of Surgeons
191(1):93-105, July 2000.
Worrall NK, Drebin
JA. Pancreaticoduodenectomy for lymphoepithelial
cyst of the pancreas. American Surgeon 66(8):732-734, Aug.
2000.
Roh H, Pippin JA, Green
DW, Boswell CB, Hirose C, Mokadam NA, Drebin JA.
HER2/neu antisense targeting of human breast carcinoma. Oncogene
19(53):6138-6143, Dec. 11, 2000.
Strasberg SM, Eagon CE,
Drebin JA. Hidden cystic duct syndrome and
the infundibular technique of laparoscopic cholecystectomy:
The danger of the false infundibulum. Journal of the American
College of Surgeons 191(6):661-667, Dec. 2000.
Strasberg SM, Dehdashti
F, Siegel BA, Drebin JA, Linehan D. Survival
of patients evaluated by FDG-PET before hepatic resection
for metastatic colorectal carcinoma: a prospective database
study. Annals of Surgery 233(3):293-299, Mar. 2001.
Strasberg SM, Picus DD,
Drebin JA. Results of a new strategy for
reconstruction of biliary injuries having an isolated right
sided component. Journal of Gastrointestinal Surgery 5(3):266-274,
May/June 2001.
Roh H, Green DW, Boswell
CB, Pippin JA, Drebin JA. Suppression of
beta-catenin inhibits the neoplastic growth of APC-mutant
colon cancer cells. Cancer Research 61(17):6563-6568, Sept.
1, 2001.
Vollmer C, Drebin
JA, Middleton WD, Teefey SA, Linehan D, Soper NJ,
Eagon CJ, Strasberg SM. Utility of staging laparoscopy in
subsets of peripancreatic and biliary malignancies. Annals
of Surgery 235(1):1-7, Jan. 2002.
Strasberg SM, Drebin
JA, Mokadam NA, Green DW, Jones K, Ehlos J, Linehan
DC. Prospective trial of a blood supply based technique of
pancreaticojejunostomy: effect on anastomotic failure in the
Whipple procedure. Journal of the American College of Surgeons
194(6):746-758, June 2002.
Strasberg SM, Drebin
JA, Linehan DC. Use of a bipolar vessel sealing device
for parenchymal transection during liver surgery. Journal
of Gastrointestinal Surgery 6(4):569-574, July/Aug. 2002.
Liyanage UK, Moore TT,
Joo H-G, Tanaka Y, Herrmann V, Doherty G, Drebin JA,
Strasberg SM, Eberlein TJ, Goedegebuure PS, Linehan DC. Prevalence
of regulatory T cells is increased in peripheral blood and
tumor microenvironment of patients with pancreas and breast
adenocarcinoma. Journal of Immunology 169(5):2756-2761, Sept.
1, 2002.
Winslow ER, Brunt LM, Drebin
JA, Soper NJ, Klingensmith ME. Portal vein thrombosis
after splenectomy. American Journal of Surgery 184(6):631-635,
Dec. 2002.
Strasberg SM, Drebin
JA, Linehan D. Radical antegrade modular pancreato-splenectomy.
Surgery 133(5):521-527, May 2003.
Veeramachaneni N, Kubokura H,
Lin L, Pippin J, Patterson A, Drebin JA,
Battafarano R. Down-regulation of beta-catenin inhibits the
growth of squamous esophageal carcinoma cells. Journal of
Thoracic and Cardiovascular Surgery 127(1):92-8, 2004 Jan.).
Fernandez FG, Drebin
JA, Linehan DC, Dehdashti F, Siegel BA, Strasberg
SM. Five-year survival after resection of hepatic metastases
from colorectal cancer in patients screened by positron emission
tomography with F-18 fluorodeoxyglucose (FDG-PET). Annals
of Surgery 240(3):438-450, Sept. 2004.
Lin
LL, Picus J, Drebin JA, Linehan DC, Solis
J, Strasberg SM, Tan B, Thorstad WL, Myerson R. A phase II
study of alternating cycles of split course radiation therapy
and gemcitabine chemotherapy for inoperable pancreatic or
biliary tract carcinoma. American Journal of Clinical Oncology
28(3):234-241, June 2005.
Canter
RJ, Kesmodel SB, Heitjan DF, Veeramachaneni NK, Mokadam NA,
Drebin JA, Fraker DL. Suppression of beta-catenin
by antisense oligomers augments tumor response to isolated
limb perfusion in a rodent model of adenomatous polyposis
coli-mutant colon cancer. Annals of Surgical Oncology 12(9):733-742,
Sept. 2005.
Lee
CJ, Scheiman J, Anderson MA, Hines OJ, Reber HA, Farrell J,
Kochman ML, Foley, PJ, Drebin J, Oh YS, Ginsberg
G, Ahmad N, Merchant NB, Isbell J, Parikh AA, Stokes JB, Bauer
T, Adams RB, Simeone DM. Risk of malignancy in resected cystic
tumors of the pancreas </= 3 cm in size: is it safe to
observe asymptomatic patients? A multiinstitutional report.
Journal of Gastrointestinal Surgery 12:234-242, 2008.
Cai
Z, Zhang G, Zhou Z, Bembas K, Drebin JA,
Greene MI, Zhang H Differential
binding patterns of monoclonal antibody 2C4 to the ErbB3-p185her2/neu
and the EGFR- p185her2/neu complexes. Oncogene 27:3870-3874,
2008.
Foley PJ, Scheri RP, Smolock
CJ, Green DW, Pippin JA, Drebin, JA. Targeted
suppression of ß-catenin blocks intestinal adenoma formation
in apc min mice. Journal of Gastrointestinal Surgery 12:1452-1458,
2008.
Linehan DC, Tan MCB, Strasberg
SM, Drebin JA, Hawkins WG, Picus J, Myerson
RJ, Malayapa RS, Hull M, Trinkaus K, Tan, BR. Adjuvant interferon-based
chemoradiation followed by gemcitabine for resected pancreatic
adenocarcinoma: a single institution phase II study. Annals
of Surgery 248:145-151, 2008.
Pippin, JA, Smolock, CJ,
Scheri, RP, Foley, PJ and Drebin, JA. (2008)
NF-?B regulates ß-catenin mRNA transcription in apc-
and ß-catenin mutant human colon cancer cells. (submitted
for publication).
Reviews in Peer-Reviewed Research Publications
Drebin JA,
Perry LL, Carter R, Greene MI. Regulation of the immune response
to antigens on the malignant cell surface. Seminars in Immunopathology
5(2):75-192, 1982.
Schatten S, Granstein RD, Drebin
JA, Greene MI. Suppressor T cells and the immune
response to tumors. Critical Reviews in Immunology 4(4): 335-379,
1984.
Schatten S, Drebin JA,
Granstein R, Greene MI. Differential antigen presentation
in tumor immunity. Federation Proceedings 43(9):2360-2364,
June 1984.
Strasberg SM, Drebin
JA, Soper NJ. Evolution and current status of the
Whipple procedure. Gastroenterology 113(3):983-994, Sept.
1997.
Green DW, Roh H, Pippin JA, Drebin
JA. Antisense oligonucleotides: an evolving technology
for the modulation of gene expression in human disease. Journal
of the American College of Surgeons 191(1):93-105, July 2000.
Zhang H, Berezov A, Wang Q, Zhang
G, Drebin J, Murali R, Greene MI. ErbB receptors:
From oncogenes to targeted cancer therapies. Journal of Clinical
Investigation 117(8):2051-2058, Aug. 2007.
Abstracts (last 3 years)
Tan, CB, Tobin, G, Yang,
YI, Drebin, JA, Hawkins, WG, Strasberg, SM,
Linehan, DC. Long-term survival and quality of life after
total pancreatectomy. Annual Meeting of the American Hepato-Pancreatico-Biliary
Association. Abstract #38. J. Gastrointestinal Surgery 9:536,
2005.
Smolock, CJ, Pippin, JA, Scheri,
R, Drebin, JA. Paradoxical effect of proteasome
inhibitors on beta-catenin expression in APC-mutant and beta-catenin-mutant
human colon cancer cells. American College of Surgeons 91st
Annual Clinical Congress - Surgical Forum. Journal of the
American College of Surgeons 201 (supplement):81-82, 2005
Smolock, CJ, Pippin, JA, Scheri,
RP, Foley, PJ, Drebin, JA. Nuclear factor
kappa B regulates beta-catenin expression and function in
human colon cancer cells. Society of Surgical Oncology, 59th
Annual Cancer Symposium - Annals of Surgical Oncology 13 (supplement
2):2, 2006.
Tan, BR, Strasberg, S, Myerson,
R, Tan, M, Hawkins, WG, Malyapa, R, Drebin, J,
Picus, J, Foster, L, Linehan, D. Adjuvant interferon- and
gemcitabine-based chemoradiation for patients with resected
pancreatic adenocarcinoma. American Society of Clinical Oncology
Gastrointestinal Cancer Symposium, Abstract #177, 2007.
Smolock, CJ, Foley, PJ, Pippin,
JA, Drebin, JA. Targeting beta-catenin in
human chronic myelogenous leukemia cells. Annual Meeting of
the American Association for Cancer Research, Abstract #718,
2007.
Wilson, VC, Guo, M, Chen, Z,
Hampshire, M, Claghorn, K, O’Dwyer, P, Sun, WJ, Rosato,
EF, Drebin, JA, Metz, JM. Aggressive supportive
care improves outcomes in the combined modality treatment
of pancreatic and duodenal cancer. American Society for Therapeutic
Radiology and Oncology, 49th Annual Meeting, Abstract #2139,
2007.
Foley PJ, Pippin JA, Smolock
CJ, Drebin JA. Non-steroidal anti-inflammatory
drugs inhibit ?-catenin in human colon cancer cells via effects
on mRNA expression. Society of University Surgeons Academic
Surgical Congress, 3rd Annual Meeting, 2008.
Foley PJ, Pippin JA, Smolock
CJ, Drebin JA. Non-steroidal anti-Inflammatory
drugs down-regulate ?-catenin in human colon cancer cells
via effects on NF-?B-dependent mRNA transcription. Society
of Surgical Oncology, 61st Annual Cancer Symposium –
Annals of Surgical Oncology 15 (supplement 2): 2, 2008.
Morgans A, Moghanaki D, Mick
R, Furth EE, Salmon, P, Behbehani A, Drebin J,
Rosato EF, Whittington R, Giantonio BJ. Survival following
resection of pancreatic cancers may not be affected by length
of hospital stay or delay to initiating adjuvant chemoradiation.
Annual Meeting of the American Society of Clinical Oncology,
Abstract #4639, 2008.
Salmon P, Moghanaki D, Mick R,
Furth EE, Behbehani A, Morgans A, Drebin J,
Rosato EF, Whittington R, Giantonio BJ. Number and percentage
of pathologically involved lymph nodes in patients with pancreatic
adenocarcinoma predicts for overall survival in patients treated
with postoperative adjuvant chemoradiotherapy. Annual Meeting
of the American Society of Clinical Oncology, Abstract #15509,
2008.
Haynes JC, Moghanaki D, Morgans
A, Salmon P, Furth EE, Giantonio BJ, Drebin J,
Rosato EF, Whittington R. Survival following partial pancreatectomy
and radiation for ampullary carcinoma. Annual Meeting of the
American Society of Clinical Oncology, Abstract #15614, 2008.
Foley PJ, Pippin JA, Smolock
CJ, Drebin JA. Growth inhibitory effects
of indomethacin on human colon cancer cells are mediated,
in-part, by effects on ?-catenin. Accepted for presentation,
American College of Surgeons, 94th Annual Clinical Congress,
2008.
Editorials, Chapters & Participation
in Committee Reports
Drebin JA,
Perry LL, Bromberg JS, Nepom J, Benacerraf B, Greene MI. The
effects of antisera directed at I-region gene products on
syngeneic tumor immunity. In: Immuno-chemotherapy. Nydegger
UE, ed. New York: Academic Press, 1981, 99-108.
Drebin JA,
Shilo BZ, Weinberg RA, Greene MI. Preliminary evidence of
an association between an activated cellular transforming
gene and a tumor-specific transplantation antigen. In: B and
T Cell Tumors. Vitetta E, Fox CF, eds. New York: Academic
Press, 1982, 221-226.
Schatten S, Drebin JA,
Takeoki M, Carter R, Tominaga A, Abbas A, Finberg R, Greene
MI. Regulation of the immune response to cell surface antigens.
In: B and T Cell Tumors. Vitetta E, Fox CF, eds. New York:
Academic Press, 1982, 349-368.
Lowy A, Tominaga A, Drebin
JA, Benacerraf B, Greene MI. Activation of suppressor
cells is genetically restricted by the I-J subregion. In:
Ir Genes: Past, Present and Future. Pierce CW, Cullen SE,
Kapp JA, Schwartz BD, Shreffler DC, eds. Clifton, NJ: The
Humana Press, 1983, 515-520.
Drebin JA, Schatten
S, Tominaga A, Lefort S, Letvin NL, Bast RC, Mizel S, Greene
MI. Characterization of ultraviolet radiation-induced impairment
of antigen presenting cell function at the cellular and molecular
level. In: The Effects of Ultraviolet Radiation on the Immune
System. Parrish J, ed. Skillman, NJ: Johnson & Johnson
Press, 1983, 123-142.
Drebin JA, Link
VC, Stern DF, Weinberg RA, Greene MI. Immune responses against
transforming gene associated antigens. In: Regulation of the
Immune System. Sercarz E, Cantor H, Chess L, eds. New York:
Alan R. Liss, Inc., 1984, 919-928.
Stern DF, Schechter A, Vaidyanathan
L, Weinberg R, Greene M, Drebin J. The neu
oncogene encodes a cell surface protein with properties of
a growth factor receptor. In: Genetics, Cell Differentiation,
and Cancer. Marks PA, ed. New York: Academic Press, 1985,
165-170.
Drebin JA, Link
VC, Stern DF, Weinberg RA, Greene MI. Development of monoclonal
antibodies reactive with the product of the neu oncogene.
In: Immunology and Cancer. Kripke M, ed. Austin, TX: University
of Texas Press, 1986, 277-289.
Drebin JA, Link
VC, Greene MI. Monoclonal antibodies reactive with the neu
oncogene product inhibit the neoplastic properties of the
neu-transformed cells. In: Development and Recognition of
the Transformed Cell. Greene MI, Hamaoka T, eds. New York:
Plenum Press, 1987, 69-80.
Drebin JA, Hartzell
SW, Niederhuber JE. Recombinant DNA technology. In: Principles
and Practices of Surgical Research. Troidl H, Spitzer WO,
McPeek B, Mulder DS, McKneally MF, Wechsler AS, Balch CM,
eds. New York: Springer-Verlag, 1991, 342-353.
Drebin JA, Hartzell
SW, Niederhuber JE. Tumor markers in cancer diagnosis and
therapy. In: Current Therapy in Oncology. Niederhuber J, ed.
Philadelphia: BC Decker, Inc., 1992, 58-61.
Drebin JA, Niederhuber
JE. Colon cancer. In: Current Therapy in Oncology. Niederhuber
J, ed. Philadelphia: BC Decker, Inc., 1992, 426-431.
Drebin JA, Mundy
LM. The management of postoperative wound infections. In:
Current Surgical Therapy, 6th Edition. Cameron J, ed. Philadelphia:
Mosby-Year Book, 1998, 1078-1082.
Strasberg SM, Drebin
JA. Tumors of the biliary tree. In: Textbook of Gastroenterology,
3rd Edition. Yamada T, ed. Philadelphia: Lippincott-Raven,
Inc., 1999, 2326-2342.
Drebin JA, Strasberg
SM. Pancreatic carcinoma and tumors of the peri-ampullary
region. In: Cancer Surgery for the General Surgeon. Winchester
DP, Daly JM, Jones RS, Murphy GP, eds. Philadelphia: Lippincott-Raven,
Inc., 1999, 195-211.
Chi D, Drebin JA.
The pancreas. In: The Washington Manual of Surgery, 2nd Edition.
Doherty GM, Meko J, Peplinski G, Olson J, Worrall N, eds.
Philadelphia: Lippincott, Williams and Wilkins, 1999, 259-272.
Strasberg S, Drebin J.
Calculous biliary disease. Chap. 41 in: Surgery: Scientific
Principles and Practice. Greenfield LJ, Mulholland MW, Oldham
KT, Zelenock GB, Lillimoe KD, eds. Philadelphia: Lippincott,
Williams and Wilkins, 2001, 9-31.
Green DW, Drebin JA.
Cancer genetics. In: Surgical Research. Souba W, Wilmore D,
eds. San Diego: Academic Press, 2001, 445-456.
Drebin JA, Strasberg
SM. Technical aspects of biliary and pancreatic reconstruction
after pancreaticoduodenectomy. In: Pancreatic Cancer.
Evans D, Pisters PWT, Abbruzzese A, eds. New York:
Springer-Verlag, Inc., 2002, 171-180.
Amos K, Drebin JA.
The pancreas. In: The Washington Manual of Surgery, 3rd Edition.
Doherty GM, Lowney GK, Mason JE, Reznick SI, Smith MA, eds.
Philadelphia: Lippincott, Williams and Wilkins, 2002, 293-306.
Drebin JA, Strasberg
SM. Tumors of the biliary tree. In: Textbook of Gastroenterology,
4th Edition. Yamada T, editor. Philadelphia: Lippincott-Raven,
Inc., 2003, 2234-2251.
Scheri R, Drebin JA.
Tumors of the small intestine. In: Current Surgical Therapy,
9th Edition. Cameron J, editor. Philadelphia: Mosby-Year Book,
Inc., 2004, 120-124.
Drebin JA. Carcinoma
of the pancreas. In: Clinical Oncology, 3rd edition. (Abeloff
MD, Armitage JO, Niederhuber JE, Kastan MB, McKenna WG, editors.
London: Churchill ivingstone, Inc., 2004, 2015-2033.
Sun WJ, Morris JB, Drebin
JA. Medical and surgical therapy of pancreaticobiliary
malignancies. In: Endoscopic Oncology: Gastrointestinal Endoscopy
and Cancer Management. Faigel DO, Kochman ML, editors. Totawa,
NJ: Humana Press, 2006, 353-363.
Kesmodel S, Drebin JA.
Tumor biology. In: The Surgical Review: An Integrated Basic
and Clinical Science Study Guide, 2nd edition. Atluri, P,
Karakousis, G, Porrett, P, Kaiser, L, editors. Philadelphia:
Lippincott, Williams and Wilkins, 2006, 61-84.
Katsumata M, Drebin JA,
Greene MI. Trastuzumab in breast cancer. [commentary] New
England Journal of Medicine 354(6):640-644, Feb. 9, 2006.
Smolock CJ, Drebin JA.
Tumors of the biliary tree. In: Textbook of Gastroenterology,
5th Edition. Yamada, T, editor. Oxford, UK: Blackwell Publishing,
2008 (in press).
Drebin, JA,
Sun, WJ, Metz, J, Furth, E. Carcinoma of the pancreas. In:
Clinical Oncology, 4th edition. Abeloff, MD, Armitage, JO,
Niederhuber, JE, Kastan, MB, McKenna, WG, editors. London:
Churchill Livingstone, Inc., 2008, 1595-1612.
Gates, J, Drebin, J.A.
Abdominal masses. In: Clinician’s Guide to Surgical
Care. Pryor, J, Todd, B, Dryer M, editors. New York: McGraw-Hill,
Inc., 2008, 225-240.
Resnick, AS, Drebin,
JA. Distal pancreatectomy. In: Pancreatic Cancer.
Lowy, A, Leach, S, Philip, P, editors. New York: Springer-Verlag,
2008 (in press).
Foley PJ, Drebin JA.
Pancreatic resection. In: Gowned and Gloved Surgery: Introduction
to Common Procedures. Roses RE, Paulson EC, Kanchwala S, editors.
Philadelphia: Elsevier, Inc. 2008 (in press).
Drebin, JA.
Pancreatic mucinous cystic neoplasms – why not resect?
[editorial] Gastrointestinal Endoscopy 2008 (in press).
Patents
Greene MI, Drebin
JA, inventors. Treatment of tumors with monoclonal
antibodies against oncogene antigens. U.S. Patent #5824311,
awarded 10/20/98. This patent has been licensed to Genentech,
Inc. by the University of Pennsylvania.
Greene MI, Katsumata M, Drebin
J, inventors. Prevention of tumors with monoclonal
antibodies against neu. U.S. Patent Application #20040202664.
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