Education | Health Care | Research | Site Map
Search:
John C. Kucharczuk, M.D.
Thoracic Surgery
 
Research Publications, Peer-Reviewed

Hwang HC, Smythe WR, Elshami AA, Kucharczuk JC, Amin KM, Williams JL, Litzky LA, Kaiser LR, Albelda SM: Gene therapy using adenovirus carrying the herpes simplex-thymidine kinase gene to treat in vivo models of human malignant mesothelioma and lung cancer. American Journal of Respiratory Cell and Molecular Biology, 13(1):7-16, July 1995.

Kucharczuk JC, Elshami AA, Zhang HB, Smythe WR, Hwang HC, Tomlinson JS, Amin KM, Litzky LA, Albelda SM, Kaiser LR: Plerual-based mesothelioma in immune competent rats: A model to adenoviral gene transfer. Annals of Thoracic Surgery, 60(3):593-598, Sept. 1995.

Elshami A, Kucharczuk JC, Sterman DH, Smythe WR, Hwang HC, Amin KM, Litzky LA, Albelda SM, Kaiser LR. The role of immune suppression in the efficacy of cancer gene therapy using adenovirus transfer of the Herpes Simplex-thymidine kinase gene. Annals of Surgery, 222(3):298-310, Sept. 1995.

Elshami AA, Kucharczuk JC, Zhang HB, Smythe WR, Litzky LA, Hwang HC, Kaiser LR, Albelda SM: Treatment of pleural mesothelioma in an immunocompetent rat model utilizing adenoviral transfer of the HSV-thymidine kinase gene. Human Gene Therapy, 7(2):141-148, Jan. 20, 1996.

Elshami AA, Saavedra A, Zhang HB, Kucharczuk JC, Spray D, Fishman GI, Kaiser LR, Albelda SM: Gap junctions play a role in the “bystander effect” of the herpes simplex virus thymidine kinase/ganciclovir system in vitro. Gene Therapy, 3(1):85-92, Jan. 1996.

Randazzo BT, Kucharczuk JC, Litzky LA, Brown MS, Kaiser LR, Fraser NW, Albelda SM: Herpes simplex 1716--- an ICP 34.5 mutant--- is severely replication restricted in human skin xenografts in vivo. Virology, 223(2):392-395, Sept. 15, 1996.

Kucharczuk JC, Raper S, Elshami AA, Smythe WR, Litzky LA, Kaiser LR, Albelda SM: Safety of intrapleurally administered recombinant adenovirus carrying herpes simplex thymidine kinase DNA followed by ganciclovir therapy in nonhuman primates. Human Gene Therapy, 7(18):2225-2233, Dec. 1, 1996.

Kucharczuk JC, Randazzo BT, Elshami AA, Sterman DH, Rizk NP, Amin KM, Molnar-Kimber KL, Brown MS, Litzky LA, Fraser NW, Albelda SM, Kaiser LR: Use of a “replication-restricted” herpes virus to treat experimental human malignant mesothelioma. Cancer Research, 57(3):466-471, Feb. 1, 1997.

Kucharczuk JC, Cohen ML, Rhodes LA, Karl TR, Spray TL, Gaynor JW: Epicardial atrial pacemaker lead placement following multiple cardiac operations. Accepted for Publication, Annals of Thoracic Surgery, 71:2057-2058, June 2001.

Deeb ME, Brinster CJ, Kucharczuk JC, Shrager JB, Kaiser LR. Expanded indications for transcervical thymectomy in the management of anterior mediastinal masses. Annals of Thoracic Surgery, 72:208-211, July 2001.

Marshall MB, Deeb ME, Bleier JL, Kucharczuk JC, Friedberg JS, Kaiser LR, Shrager JB. Suction vs. water seal after pulmonary resection: A randomized prospective study. Chest, 121(3): 831-835, March 2002.

Singhal S, Weiwrodt R, Malden, L, Matzie K, Friedberg J, Amin KM, Kucharczuk JC, Litzky LA, Johnson SW, Kaiser LR, Albelda SM. Gene expression mapping of malign-nant mesothelioma. Clinical Cancer Research, 9(8):3080-3097, Aug. 1, 2003.

Singhal S, Amin KM, Kruklitis R, Marshall MB, Kucharczuk JC, DeLong P, Litzky LA, Kaiser LR, Albelda SM. Differentially expressed apoptotic genes in early stage lung adenocarcinoma predicted by expression profiling. Cancer Biology & Therapy, 2(5):566-571, Sept./Oct. 2003.

Kucharczuk JC, Kaiser LR, Marshall MB. Weerda Diverticuloscope: Novel technique for removal of esophageal foreign body. Annals of Thoracic Surgery, 76(4):1276-1278, Oct. 2003.

Paulson EC, Singhal S, Kucharczuk JC, Sterman DH, Kaiser LR, Marshall MB. Bronchial sleeve resection for posttransplant stricture. Annals of Thoracic Surgery, 76(6):2075-2076, Dec. 2003.

Brinster CJ, Singhal S, Lawrence L, Marshall MB, Kaiser LR, Kucharczuk JC. Evolving options in the management of esophageal perforation. Annals of Thoracic Surgery, 77(4):1475-1483, Apr. 2004.

Marshall, MB, Kaiser LR, Kucharczuk JC. Simple technique for maximal thoracic muscle harvest. Annals of Thoracic Surgery 77(4):1465-1466, Apr. 2004.

Ahmed Z, Marshall MB, Kucharczuk JC, Kaiser LR, Shrager JB. Lung cancer in trans-plant recipients: A single institution experience. Archives of Surgery 139(8):902-906, Aug. 2004.

Marshall MB, Ahmed Z, Kucharczuk JC, Kaiser LR, Shrager JB. Catamenial pneumo-thorax: optimal hormonal and surgical management. European Journal of Cardio-Thoracic Surgery 27(4):662-666, Apr. 2005.

Lee L, Nance M, Kaiser LR, Kucharczuk JC. Familial massive leiomyoma with esophageal leiomyomatosis: An unusual presentation in a father and his two daughters. Journal of Pediatric Surgery 40(5):e29-32, May 2005.

Kucharczuk JC, Kaiser LR. Radical lobectomy, esophagectomy, and mediastinal dissections for intrathoracic malignancy. Surgical Oncology Clinics of North America 14(3):499-509, vi, July 2005.

O'Brien PK, Kucharczuk JC, Marshall MB, Friedberg JS, Chen Z, Kaiser LR, Shrager JB. Comparative study of subxiphoid versus video-thoracoscopic pericardial "window". Annals of Thoracic Surgery 80(6):2013-2019, Dec. 2005.

Marshall MB, Kucharczuk JC, Shrager JB, Kaiser LR. Anterior surgical approaches to the thoracic outlet. Journal of Thoracic & Cardiovascular Surgery. 131(6):1255-60, Jun 2006.

Levine S, Nguyen T, Friscia M, Zhu J, Szeto W, Kucharczuk JC, Tikunov B, Rubinstein N, Kaiser LR, Shrager JB. Parasternal intercostal muscle remodeling in severe chronic obstructive pulmonary disease. Journal of Applied Physiology Jun 22, 2006; [Epub ahead of print].

Reviews in Peer-Reviewed Research Publications
Lee LS, Singhal S, Brinster CJ, Marshall B, Kochman ML, Kaiser LR, Kucharczuk JC. Current management of esophageal leiomyoma. [Review] Journal of the American College of Surgeons, 198(1):136-146, Jan. 2004.

Kucharczuk JC. Radiofrequency ablation: Emerging therapy for the small pulmonary nodule? [Review] Seminars in Thoracic & Cardiovascular Surgery 17(2):134-137, 2005.

Abstracts (last 3 years)
Singhal S, Kucharczuk JC, Marshall MB, Albelda SM, Kaiser LR. Transcript profiling of patients with N0 lung adenocarcinomas to predict survival. 83rd Annual Meeting of the American Association for Thoracic Surgery, Boston, MA, May 4-7, 2003.

Singhal S, Kruklitis, RJ, Marshall MB, Kucharczuk JC, Albelda SM, Kaiser LR. Viral gene transfer of IL-12 prolongs survival and prevents recurrence in early and advanced non-small cell lung cancer. Surgical Forum of the American College of Surgeons, 2003.

Ahmed Z, Marshall MB, Kucharczuk JC, Kaiser LR, Shrager JB. Bronchogenic Carci-noma in immunosupressed transplant recipients. Surgical Forum of the American College of Surgeons, 2003.

Kreider ME, Ahmad NN, Hansen-Flaschen JC, Kaiser LR, Brinster C, Kucharczuk JC, Shrager JB. Complications of thoracoscopic lung biopsy in patients with interstitial lung disease. Presented at the American College of Chest Physicians Meeting, Montreal, CA Nov. 2005.

Shrager JB, Nathan DP, Spence AM, Kurichi JE, Kucharczuk JC, Kaiser LR. Comparative study of anterior and posterior approaches to pancoast tumors at a single institution. Submitted to American Association for Thoracic Surgery May 2006.

Kucharczuk JC, Shrager JB, Kaiser LR. Use of modern orthopedic fixation techniques for sternal stabilization. Submitted to Society of Thoracic Surgeons, June 2006.

Kucharczuk JC, Shrager JB, Kaiser LR, Cooper JD. Transcervical Thymectomy for Non Thymomatous Myasthenia Gravis. Submitted to the Society of Thoracic Surgeons, June 2006.

Editorials, Chapters & Participation in Committee Reports
Buzby GP, Kucharczuk JC. Changes in immunologic function. Chap. 23 in Nutrition and Metabolism in the Surgical Patient, Second Edition. Fischer JE (ed). Boston: Little, Brown & Co., 1995, 623-635.

Kucharczuk JC, Kaiser LR. Invited Review: Literature review in video-assisted thoracic surgery. Contemporary Surgery, Nov. 2002.

Kucharczuk JC. Cancer of the lung from molecular biology to treatment guidelines (Weitberg AB, editor). Human Pathology, 33(4):451, Apr. 2002.

Kucharczuk JC. Invited book review: Thoracic surgical oncology: Exposures & tech-niques (Nesbit JG and Wind GG, editors). Annals of Thoracic Surgery, 77(1):167, Jan. 2004.

Kucharczuk JC, Kaiser LR. Radical lobectomy, esophagectomy and mediastinal dissections for intra thoracic malignancy. Surgical Clinics of North America: The Evolutions of Radical Cancer Surgery in Oncology. 14(3):499-509, July 2005.

Kucharczuk JC, Shrager JB. Anterior mediastinal masses. Sabiston & Spencer: Surgery of the Chest, Seventh Edition. New York: Elsevier, 2005, 667-680.

Kucharczuk JC. Surgical management of esophageal neoplasms. In The Clinician's Guide to Gastrointestinal Oncology. Thorofare, NJ: SLACK Incorporated Professional Book Division, 2005, 11-22.

Kucharczuk JC, Kaiser LR. Esophageal tumors and injury. Greenfield’s Surgery: Scientific Principles & Practice, 4th Edition. Greenfield, LJ (ed). Philadelphia: Lippincott Williams & Wilkins, 2005, __-__.

Kucharczuk JC, Kaiser LR. Bronchoplastic procedures. In Operative Thoracic Surgery. Jamieson GJ and Kaiser LR (eds). London: Oxford University Press, 2006 (in press).

Kucharczuk JC, Kaiser LR. Flexible and rigid bronchoscopy. In Operative Thoracic Surgery. Jamieson GJ and Kaiser LR (eds). London: Oxford University Press, 2006 (in press).

Kucharczuk JC. Pericardium. In Operative Thoracic Surgery. Jamieson GJ and Kaiser LR (eds). London: Oxford University Press, 2006 (in press).

Kucharczuk JC, Friedberg JS. The pleura. Norton’s Textbook of Surgery. 2006 (in press).

Kucharczuk JC. Chest wall resection. Mastery of Cardiothoracic Surgery. 2006 (in press).

Kucharczuk JC, Kaiser LR. Surgical techniques: Surgery of pectus deformities. Pearson’s Thoracic Surgery. Pearson FG (ed.), Philadelphia: Churchill Livingstone, 2006 (in press).

Alternative Media
Kucharczuk JC. Review, Pier on line Project, American College of Physicians-American Society of Internal Medicine, Pneumothorax Module 2002.

Kucharczuk JC. TissueLink resection of metastatic renal cell to the lung with en-bloc chest wall resection. (multimedia presentation) (link).

Kucharczuk JC. Surgical management of lung abscess. Thoracic Surgery Directors Online Requisite Curriculum Publication, July 2003. (link)

Kucharczuk JC. Congenital lung abnormalities module: Pulmonary sequestration. Multimedia Presentation. Thoracic Surgery Directors Requisite Online Curriculum Publication. July 2003. (link)

Kucharczuk JC, Kaiser LR. Resection of symptomatic, complex aspergilloma.
Available at: http://www.ctsnet.org/doc/8793. Posted Feb. 9, 2004.

Kucharczuk JC. 2: Chest Wall Mass, 4: Thorax. ACS Surgery Online. Souba WW, Fink MP, Jurkovich, GJ et al, Eds. WebMD Inc., New York 2005, Oct. 2005. (link)

Kucharczuk JC. American College of Surgeon’s Weekly Curriculum: Apr. 5, 2006 -- Chest Wall Mass, http://www.acssurgery.com/acsw, The ACS Surgery Weekly Curriculum, 111 Eighth Avenue, Suite 700, New York, NY 10011, Posted Apr. 5, 2006.

Patents
Kucharczuk JC. Application No.09/117,218 USPTO: Treatment of Non-Neuronal Cancer Using HSV Mutant (Application under review).

 


About Penn Medicine   Contact Us   Site Map   Privacy Statement   Legal Disclaimer   Terms of Use

Penn Medicine , Philadelphia, PA 1-800-789-PENN © 2009, The Trustees of the University of Pennsylvania