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Julia C. Tchou, M.D., Ph.D.
Endocrine and Oncology Surgery
 
Research Publications, peer reviewed

Tchou J, Kasai H, Shibutani S, Chung MH, Laval J, Grollman AP, Nishimura S. 8-oxoguanine (8-hydroxyguanine) DNA glycosylase and its substrate specificity. Proceedings of the National Academy of Sciences of the United States of America 88(11):4690-4694, June 1, 1991.

Michaels ML, Tchou J, Grollman AP, Miller JH. A repair system for 8-oxo-7, 8-dihydrodeoxyguanine. Biochemistry 31(45):10964-10968, Nov. 17, 1992.

Tchou J, Michaels ML, Miller JH, Grollman AP. Function of the zinc finger in Escherichia coli Fpg protein. Journal of Biological Chemistry 268(35):26738-26744, Dec. 15, 1993.

Tchou J, Bodepudi V, Shibutani S, Antoshechkin I, Miller J, Grollman AP, Johnson F. Substrate specificity of Fpg protein: Recognition and cleavage of oxidatively damaged DNA. Journal of Biological Chemistry 269(21):15318-15324, May 27, 1994.

Tchou J, Grollman AP. The catalytic mechanism of Fpg protein: Evidence for a Schiff base intermediate and amino terminus localization of the catalytic site. Journal of Biological Chemistry 270(19):11671-11677, May 12, 1995.

Tchou JC, Lin X, Freije D, Isaacs WB, Brooks JD, Rashid A, De Marzo AM, Kanai Y, Hirohashi S, Nelson WG. GSTP1 CpG island DNA hypermethylation in hepatocellular carcinomas. International Journal of Oncology 16(4):663-676, Apr. 2000.

Yam M, Tchou J, English R, Highnam R, Highnam R, Roskell D, Greenall M, Brady M. A mammographic dilemma: Calcification or haemosiderin as a cause of opacities? Validation of a new digital diagnostic tool. British Journal of Radiology 74(887):1048-1051, Nov. 2001.

Tchou J, Hou N, Rademaker A, Jordan VC, Morrow M. Acceptance of tamoxifen chemo-prevention by physicians and women at risk. Cancer 100(9):1800-1806, May 1, 2004.

Durduran T, Choe R, Yu G, Zhou C, Tchou JC, Czerniecki BJ, Yodh AG. Diffuse optical measurement of blood flow in breast tumors. Optics Letter 30, 2915-2917, 2005.

Cheville A, Tchou J. Barriers to rehabilitation of breast cancer patients. Seminars in Surgical Oncology 2007 (accepted for publication).

Reviews in Peer-Reviewed Research Publications
Tchou J, Grollman AP. Repair of DNA containing the oxidatively-damaged base, 8-oxoguanine. Mutation Research 299(3-4):277-287, May 1993.

Grollman AP, Johnson F, Tchou J, Eisenberg M. Recognition and repair of 8-oxoguanine and formamidopyrimidine lesions in DNA. Annals of the New York Academy of Sciences 726:208-214, July 29, 1994.

Tchou J, Morrow M. Available models for breast cancer risk assessment: How accu-rate are they? Journal of American College of Surgeons 197(6):1029-1035, Dec. 2003.

Abstracts, past 3 years
Tchou J, Greshock J, Rebbeck T, Weber L and Solin L. Predicting distant metastasis after local recurrence (failure) in women treated by breast conserving treatment. Abstract no. 1060, 28th annual San Antonio Breast Cancer Symposium, Breast Cancer Research and Treatment 94(1), 2005.

Tchou, J, Ward, R, Volpe, P, Medina, A, Weber, B, Domchek, S and Nathanson, K. Frequency of BRCA1 and BRCA2 genomic rearrangements and mutations in men with breast cancer: A clinic-based study in the United States, Society of Surgical Oncology Annual Meeting, March 2006.

Tchou J, Sonnad S, Sargen M, Weber K, Nathanson S, Domchek S. Contralateral prophylactic mastectomy in affected carriers of deleterious BRCA1 or BRCA2 mutations: Does timing of genetic testing matter? Abstract no. 10512, ASCO Annual Meeting Proceedings, 2006.

Tchou J, Wang LP, Sargen M, Sonnad S, Tomaszewski J, and Schnall M. Do triple-negative breast cancers have a distinct imaging phenotype? Abstract no. 551108, 29th Annual San Antonio Breast Cancer Symposium, 2006.

Tchou J, Sargen M, Sonnad S, Weber BL, Nathanson K, Domchek S. Characteristics of BRCA1 and BRCA2 mutation carriers who chose prophylactic mastectomy. Accepted as Poster Presentation, Society of Surgical Oncology Annual Meeting, Mar. 2007.

Roses RE, Sargen M, Vapiwala N, Czerniecki B, Solin LJ, Tchou J. Clinical, histologic, and mammographic features of recurrent breast cancers following breast conserving therapy. Accepted as Oral Presentation, Society of Surgical Oncology Annual Meeting, Mar. 2007.

Editorials, Chapters & Participation in Committee Reports
Tchou J, Morrow M. Overview of clinical risk assessment. In Morrow M, Jordan VC (eds): Managing Breast Cancer Risk. Hamilton, Ontario: BC Decker, 2003, pp. 3-25.

Kruper L, Tchou J. The breast. In Atluri P, Karakousis GC, Porrett PM, Kaiser LR (eds): The Surgical Review. 2nd Edition. Philadelphia, PA: Lippincott Williams & Wilkins, 2006, pp. 502-517.

Patents
Nelson WG, Lin X, Tchou JC, Bakker J. Genetic diagnosis of hepatocellular carcinoma (liver cancer). JHU Ref. DM-3602, 2003; patent pending.

 


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