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Joseph S. Friedberg, M.D.
Thoracic Surgery
 
Research Publications, Peer-Reviewed

Winter HS, Black PR, Bhan AK, Quereshi S, Friedberg JS, Ryan DP, Folkman J: A model to study development of immune function in the human small intestine. Adv Exp Med Biol 216B:1377-1381, 1987.

Friedberg JS, Tompkins RG, Rakestraw SL, Warren S, Fischmann A, Yarmush ML. Antibody targeted proteolysis: bactericidal effects of Sn(IV) chlorine e6-dextran-monoclonal antibody conjugates. Ann NY Acad Sci 618:383-393, 1991.

Cannon JG, Friedberg JS, Gelfand JA, Tompkins RG, Burke JF, Dinarello CA: Circu-lating interleukin-1b and tumor necrosis factor-a following burn injury in humans. Crit Care Med 20(10):1414-1419, Oct. 1992.

Dunn JCY, Friedberg JS, Tompkins RG, Yarmush ML: Hepatocytes from rat liver perfu-sions: Physiochemical effects on polyribosome size. ASAIO J 38(4):841-845, Oct.-Dec. 1992.

Stevens EJ, Ryan CM, Friedberg JS, Barnhill RL, Yarmush ML, Tompkins RG: A quan-titative model of invasive Pseudomonas infection in burn injury. J Burn Care Rehabil 15(3):232-235, May/June 1994.

Kaiser LR, Friedberg JS: Adjuvant therapy of lung cancer: Introduction. Semin in Thorac Cardiovasc Surg 9(1):55, Jan. 1997.

Friedberg JS, Kaiser LR: Epidemiology of lung cancer. Sem in Thorac Cardiovasc Surg 9(1):56-59, Jan. 1997.

Miller WT Jr., Tino G, Friedberg JS: Thoracic CT in the intensive care unit: Assessment of clinical utility. Semin Roentgenol 32(2):117-121, 1997.

Lennon PF, Hartigan PM, Friedberg JS: Clinical management of patients undergoing concurrent cardiac surgery and pulmonary resection. J Cardiovasc Vasc Anes 12(5):587-590, Oct. 1998.

Roberts JR, Bavaria JE, Wahl P, Wurster A, Friedberg JS, Kaiser LR: Comparison of open and thoracoscopic bilateral volume reduction surgery: Complications analysis. Ann Thorac Surg 66(5):1759-1765, Nov. 1998.

Miller WT Jr, Tino G, Friedberg JS: Thoracic CT in the intensive care unit: Assessment of clinical usefulness. Radiology 209(2):491-498, Nov. 1998.

Lee JH, Machtay M, Kaiser LR, Friedberg JS, Hahn SM, McKenna WG: Non-small cell lung cancer: Prognostic factors in patients treated with surgery and postoperative radiation therapy. Radiology 213(3):845-852, Dec. 1999.

Friedberg JS: Clinical presentation of stage IIIA (N2) non-small cell lung cancer: Role of multimodality therapy. Chest 116(6 Suppl):497S-499S, Dec. 1999.

Shrager JB, Friedberg JS, Kaiser LR: Lung volume reduction surgery. Semin Respiratory Critical Care Med 20(5):453-462, 1999.

Shrager JB, Lambright ES, McGrath CM, Wahl PM, Deeb ME, Friedberg JS, Kaiser LR: Lobectomy with tangential pulmonary artery resection without regard to pulmonary func-tion. Ann Thorac Surg 70(1):234-239, July 2000.

Sanfilippo NJ, Hsi A, DeNittis AS, Ginsberg GG, Kochman ML, Friedberg JS, Hahn SM: Toxicity of photodynamic therapy after combined external beam radiotherapy and intra-luminal brachytherapy for carcinoma of the upper aerodigestive tract. Lasers Surg & Med 28(3):278-281, 2001.

Yu GH, Soma L, Hahn S, Friedberg JS: Changing clinical course of patients with malignant mesothelioma: Implications for FNA cytology and utility of immunocytochemical staining. Diag Cytopathol 24(5):322-327, May 2001.

Wain JC, Kaiser LR, Johnstone DW, Yang SC, Wright CD, Friedberg JS, Feins RH, Heitmiller RF, Mathisen DJ, Selwyn MR: Trial of a novel synthetic sealant in preventing air leaks after lung resection. Ann Thorac Surg 71(5):1623-1629, May 2001.

Friedberg JS, Skema C, Baum ED, Burdick J, Vinogradov SA, Wilson DF, Horan AD, Nachamkin I: In vitro effects of photodynamic therapy on Aspergillus fumigatus. J Antimicrob Chemother 48(1):105-107, July 2001.

Shrager JB, Kozyak BW, Roberts JR, Bavaria JE, Friedberg JS, Kaiser LR, Rosengard BR: Successful experience with simultaneous lung volume reduction and cardiac procedures. J Thorac Cardiovasc Surg 122(1):196-197, July 2001.

Marshall MB, Deeb ME, Bleier JI, Kucharczuk JC, Friedberg JS, Kaiser LR, Shrager JB: Suction vs water seal after pulmonary resection: a randomized prospective study. Chest 121(3):831-835, Mar. 2002.

Robnett TJ, Machtay M, Hahn SM, Shrager JB, Friedberg JS, Kaiser LR: Pathological response to preoperative chemoradiation worsens with anemia in non-small cell lung cancer patients. Cancer J 8(3):263-267, May/June 2002.

Friedberg JS, Mick R, Stevenson J, Metz J, Zhu T, Buyske J, Sterman DH, Pass HI, Glatstein E, Hahn SM: A phase I study of Foscan-mediated photodynamic therapy and surgery in patients with mesothelioma. Ann Thorac Surg 75(3):952-959, Mar. 2003.

Yom SS, Busch TM, Friedberg JS, Wileyto EP, Smith D, Glatstein E, Hahn SM: Elevated serum cytokine levels in mesothelioma patients who have undergone pleurectomy or extrapleural pneumonectomy and adjuvant intraoperative photodynamic therapy. Photochem Photobiol 78(1):75-81, July 2003.

Singhal S, Wiewrodt R, Malden LD, Amin KM, Matzie K, Friedberg J, Kucharczuk JC, Litzky LA, Johnson SW, Kaiser LR, Albelda SM. Gene expression profiling of malignant mesothelioma. Clin Cancer Res 9(8):3080-3097, Aug. 1, 2003.

Friedberg JS, Skema C, Burdick J, Yodh AG, Carr SR, Culver JP: A novel technique for light delivery through branched or bent anatomic structures. J Thorac Cardiovasc Surg 126(6):1963-1967, Dec. 2003.

Rodriguez E, Park P, Cowan S, Weinstein M, Kaulback K, Friedberg JS, Diehl JT, Mannion JD, Cohen M: Complicated management of a traumatic aortoesophageal fistula in a patient with a right-sided aortic arch. J Trauma 56(3):691-693, Mar. 2004.

Friedberg JS, Mick R, Stevenson JP, Zhu T, Busch TM, Shin D, Smith D, Culligan M, Dimofte A, Glatstein E, Hahn SM: Phase II trial of pleural photodynamic therapy and surgery for patients with non-small-cell lung cancer with pleural spread. J Clin Oncol 22(11):2192-2201, June 1, 2004.

Carr SR, Pechet TV, Friedberg JS: Treatment of stage III A non-small cell lung cancer. Clin Lung Cancer 2005.

Friedberg JS, Skerna CS, Burdick J, Yodh AG, Carr SR, Horan AD, Culver JP: Altering the optical properties of the bronchial tree permits illumination of an entire lung for photodynamic therapy. J Thorac Cardiovasc Surg 2005 (accepted for publication).

Reviews in Peer Reviewed Research Publications
Kaiser LR, Friedberg JS: The role of surgery in the multimodality management of non-small cell lung cancer. [Review] Sem in Thorac Cardiovasc Surg 9(1):60-79, Jan. 1997.

Machtay M, Friedberg JS: The role of radiation therapy in the management of non-small cell lung cancer. [Review] Sem in Thorac Cardiovasc Surg 9(1):80-89, Jan. 1997.

Greelish JP, Friedberg JS: Secondary pulmonary malignancy. [Review] Surg Clin NA 80(2):633-657, Apr. 2000.

Hahn SM. Smith RP. Friedberg J: Photodynamic therapy for mesothelioma. [Review] Curr Treatment Options Oncol 2(5):375-383, Oct. 2001.

Metz JM, Friedberg JS: Endobronchial photodynamic therapy for the treatment of lung cancer. [Review] Chest Surg Clin NA 11(4):829-839, Nov. 2001.

Sterman DH, Sztejman E, Rodriguez E, Friedberg J: Diagnosis and staging of "other bron-chial tumors". [Review] Chest Surgery Clinics of North America 13(1):79-94, Feb. 2003.

Rodriguez E, Baas P, Friedberg JS. Innovative therapies: Photodynamic therapy. [Review] Thorac Surg Clin 14(4):557-566, Nov. 2004.

Research Publications, Non-Peer-Reviewed
Friedberg JS, Ryan DP, Driscoll SG, Folkman J. Human small bowel transplants into athymic mice and rats. Surgical Forum 36:375-378, 1985.

Abstracts (past 3 years)
Friedberg JS: Increased survival and local control is observed for patients with stage 3B non-small cell lung cancer (NSCLS), secondary to malignant pleural effusions and gross pleural carcinomatosis in a phase II trial combining surgery and photodynamic therapy (PDT). Chest July 2002.

Friedberg JS, Metz JM, Stevenson J, Carr SR, Zhu T, Mick R, Smith D, Culligan JM, Miles J, Glatstein E, Hahn SM: Increased survival and local control is observed for patients with stage 3B non-small cell lung cancer (NSCLC), secondary to malignant pleural effusions and gross pleural carcinomatosis, in a phase II trial combining surgery and photodynamic therapy (PDT). Presented at Chest 2002, San Diego, CA, July 2002 (selected for the ACCP Posters of Distinction, Nov. 2002).

Friedberg JS, Skema CS, Burdick J, Yodh AG< Horan AD, Carr SR, Culver JP: Altering the optical properties of the bronchial tree permits illumination of an entire lung for photodynamic therapy. Presented as part of Pennsylvania Association of Thoracic Surgeons, Miami, FL, Oct. 2002.

Friedberg JS: Phase II trial of pleural PDT and surgery for patients with NSCLC and pleural spread. Presented as part of the 9th World Congress of the International Photodymanic Association, Miyazaki, Japan, May 2003.

Friedberg JS, Skema CS, Burdick J, Yodh AG, Horan AD, Carr SR, Culver JP: Altering the optical properties of the bronchial tree permits illumination of an entire lung for photodynamic therapy. Presented as part of the AATS Meeting, Boston, MA, May 2003.

Carr SR, Cowan SW, Friedberg JS: Artificial lung in a porcine model: Using peritoneal perfusion with perfluorocarbon. Presented as part of Chest 2003, Orlando, FL, July 2003 (selected for the ACCP Posters of Distinction, Oct. 2003).

Collins JE, Carr SR, Sims TD, Friedberg JS: Porfimer sodium-mediated photodynamic therapy for aspergillus fumigatus. Presented at the American Society for Laser Medicine and Surgery, Dallas, TX, April 2004.

Friedberg JS, Carr SR, Cantor JP, Collins JE, Sims TD: Development of a murine model of localized aspergillosis. Poster Session 3: Basic Science, Surgical Infection Society Meeting, Apr. 30, 2004.

Carr SR, Cantor J, Collins JE, Sims TD, Friedberg JS: Peritoneal perfusion with perfluoro-carbon in a large animal model. Presented as part of the Philadelphia College of Surgeons Meeting, Philadelphia, PA. May 2004.

Carr SR, Cantor J, Friedberg JS: Utilizing the peritoneum for gas exchange with oxygenated perfluorocarbons. Presented as part of the American College of Surgeons Meeting, Critical Care Session, New Orleans, LA, Oct. 2004.

Friedberg JS, Cantor JP, Carr SR, Rodriguez E, Stripp D, Stevenson J, Zhu T, Smith D, Culligan M, Dimofte A, Glatstein E, Hahn S: Metastatic non-lung cancer carcinomas and sar-comas treated with photodynamic therapy. Presented as part of Chest, Seattle, WA, Oct. 2004.

Cantor JP, Carr SR, Rao AS, Collins JE, Friedberg JS. Gastric perfusion with perflurocarbon results in significant systemic oxygenation in a large animal model. Society of Critical Care Medicine, Phoenix, AZ, January 2005 (scheduled).

Cantor JP, Carr SR, Rao AS, Friedberg JS. Endoscopic techniques to use the stomach and peritoneal cavity as an “artificial lung.” Society of American Gastrointestinal Endoscopic Surgeons, Fort Lauderdale, FL, April 2005 (scheduled).

Cantor JP, Carr SR, Rao AS, Collins JE, Friedberg JS. An artificial lung in a large animal model using gastric and peritoneal perfusion with oxygenated perflurocarbons. American Association for Thoracic Surgery 85th Annual Meeting, San Francisco, CA, April 2005 (scheduled).

Cantor JP, Rao AS, Druck T, Wachsberger P, Friedberg JS, Huebner K. Decreased tumorigenicity of lung cancer cells by minimal Fhit expression. American Association for Cancer Research 2005. Anaheim, CA. April 2005 (scheduled).

Cantor JP, Pechet TV, Berd D, Tessonneaud A, Salvat S, Mitra M, Schea H, Rao AS, Lakshman TV, Collins JE, Kuchar J, Culligan M, Shrager J, Friedberg JS. Generation of an autologous, Hapten-modified non-small cell lung cancer vaccine. American Association of Cancer Research 2005. Anaheim, CA. April 2005 (scheduled).

Krug L, Pass H, Rusch V, Bloss, Sugarbaker D, Friedberg JS, Vogelzang. A multicenter phase II trial of neo-adjuvant pemetrexed plus cisplatin followed by extrapleural pneumo-nectomy and radiation for pleural mesothelioma. American Association of Clinical Oncology Meeting 2005. Orlando, FL. May 2005 (scheduled).

Editorials, Chapters and Participation in Committee Reports
Friedberg JS, Kaiser LR: The role of video-assisted thoracic surgery management of pulmonary cancer and tumors of the mediastinum. Chap. 7 in Geraghty JG, Young HL, Sackier JM, Stoldt HS, Audisio RA (eds): Minimal Access Surgery in Oncology. London: Greenwich Medical Media, 1998, 83-98.

Friedberg JS, Greelish JP: Secondary pulmonary malignancy; A multidisciplinary
approach to cancer. Surgical Clinics of North America 80(2):633-657, Apr. 2000.

Friedberg JS, Lanuti M: The esophagus. Chap. 12 in Kreisel K, Krupnick AS, Kaiser LR (eds.): The Surgical Review: An Integrated Basic and Clinical Science Study Guide. Philadelphia: Lippincott Williams & Wilkins, 2001, 185-196.

Friedberg JS, Deeb M: Treatment of esophageal perforation. In Baker RJ (ed.): Mastery of Surgery, Fourth Edition. Philadelphia: Lippincott Williams & Wilkins, 2001, 843-853.

Friedberg JS: The pleura: Anatomy, physiology and disorders. In Norton JA, Bollinger RR, Chang AE, Lowry SF, Mulvihill SJ, Pass HI, Thompson RW, Li M (eds.): Essential Practice of Surgery. New York: Springer Verlag, 2003, 1243-1264.

Friedberg JS, Hahn S: Foscan-mediated photodynamic therapy and operation for malig-nant pleural mesothelioma. [Editorial] Ann Thorac Surg 78:388-389, June 2004.

Friedberg JS, Cohn H, Rodriguez E: Secondary lung tumors. Chap. 23 in Selke F, Swanson S., del Nido PJ (eds.): Sabiston & Spencer’s Surgery of the Chest, 7th Edition. Philadelphia: Elsevier Science, 2005, Vol. I, 337-354.

Friedberg JS: The pleura: Anatomy, physiology and disorders. Chap. 56 in Norton JA, Bollinger R, Chang AE, Lowry SF, Mulvihill SJ, Pass HI, Thompson RW (eds.): Surgery: Basic Science and Clinical Evidence, 2nd Edition. New York: Springer-Verlag, Inc., 2005 (in press).

Friedberg JS: Malignant pleural effusion and malignant pericardial effusion. Chap. 57 in Pass HI, Carbone DP, Johnson DH, Minna JD, Turrisi AT III (eds.): Lung Cancer: Principles and Practice, Third Edition. Philadelphia: Lippincott, Williams & Wilkins, 2005 (in press).

Friedberg JS, Rodriguez E, Baas P: Innovative therapies: Photodynamic therapy. Chap. 14 in Chest Surgery Clinics of North America (Topic – Mesothelioma). Philadelphia: Elsevier Science (USA), 2005 (in press).

Friedberg JS, Carr S: Malignant effusions. Chap. 89 in Oncology: An Evidence-Based Approach. New York: Springer-Verlag, Inc., 2005 (in press).

Friedberg JS: Mediastinotomy. Kaiser & Jamieson: Operative Thoracic Surgery, Fifth Edition. Oxford, UK: Oxford University Press, 2005 (in press).

Friedberg JS: Overview of cancer of the upper airways. Adult Chest Surgery: Concepts and Procedures. New York: McGraw-Hill Professional, 2005 (in press).

Friedberg JS: Segmentectomy. Adult Chest Surgery: Concepts and Procedures. New York: McGraw-Hill Professional, 2005 (in press).

Friedberg JS: Photodynamic therapy in the management of pleural effusions. Adult Chest Surgery: Concepts and Procedures. New York: McGraw-Hill Professional, 2005 (in press).

Friedberg JS: Surgical management of malignant mesothelioma. Mastery of Cardiothoracic Surgery. Lippincott Williams & Wilkins, 2005 (in press).

Alternative Media
Friedberg JS: Video mediastinoscopy and surgical advances for treating lung cancer. Live WebCast, Thomas Jefferson University Hospital, Philadelphia, PA, 2002.

Friedberg JS: Surgical treatment of lung cancer and photodynamic therapy in the treatment of advanced lung cancer. Rowan University Radio Station “Your Health Matters,” Oct. 2004.

Patents
Friedberg JS. System oxygenation via gastric perfusion with perfluorocarbon (PFC). U.S. Patent and Trademark serial number pending, 2005.

Friedberg JS. Investigational new drug (IND): Autologous Hapten-modified non-small cell lung cancer vaccine. Patent number pending, 2005.

 


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