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Kim M. Olthoff, M.D., FACS
Transplant Surgery
 
Research Publications, Peer Reviewed

Olthoff KM, Millis JM, Imagawa DK, Nuesse BJ, Derus LJ, Rosenthal JT, Milewicz AL, Busuttil RW: Comparison of University of Wisconsin solution vs. EuroCollins solution for the cold preservation of human liver grafts. Transplantation 49(2): 284-290, Feb. 1990.

Imagawa DK, Millis JM, Olthoff KM, Seu P, Dempsey RA, Hart J, Terasaki PI, Busuttil RW: Anti-tumor necrosis factor antibody therapy enhances allograft survival in rats. Journal of Surgical Research 48(4): 345-348, Apr. 1990.

Baquerizo A, Kamada N, Millis JM. Hart J, Pera C, Olthoff KM, Orloff M, Iwaki Y, Busuttil RW. Influence of number and timing of serum transfusions on liver allograft survival. Transplantation Proceedings 22(4): 2020-2022, Aug. 1990.

Imagawa DK, Millis JM, Olthoff KM, Derus LJ, Chia D, Sugich LR, Ozawa M, Dempsey RA, Iwaki Y, Levy PJ, Busuttil RW: The role of tumor necrosis factor in allograft rejection: I. Elevated levels of tumor necrosis factor-alpha predict rejection following orthotopic liver transplantation. Transplantation 50(2):219-225, Aug. 1990.

Imagawa DK, Millis JM, Olthoff KM, Seu P, Dempsey RA, Hart J, Terasaki PI, Busuttil RW. The role of tumor necrosis factor in allograft rejection: II. Evidence that antibody therapy against tumor necrosis factor-alpha and lymphotoxin enhances cardiac allograft survival in rats. Transplantation 50(2):189-193, Aug. 1990.

Busuttil RW, Seu P, Millis JM, Olthoff KM, Hiatt JR, Milewicz A, Neusse BJ, El-Khoury G, Raybould D, Nyerges AM, Vargas JH, McDiarmid SV, Berquist W, Harrison R, Ament ME. Liver transplantation in children. Annals of Surgery 213(1): 48-57, Jan. 1991.

Imagawa DK, Millis JM, Seu P, Olthoff KM, Hart J, Dempsey RA, Stephens S, Busuttil RW. The role of tumor necrosis factor in allograft rejection: III. Anti-TNF antibody therapy prolongs allograft survival in rats with acute rejection. Transplantation 51(1): 57-62, Jan. 1991.

Seu P, Imagawa DK, Olthoff KM, Millis JM, Hart J, Wasef E, Dempsey RA, Busuttil RW. Effects of tumor necrosis factor (TNF) and immunotherapy directed against TNF on rat cardiac transplants. Transplantation Proceedings 23(1 Pt 1): 233-234, Feb. 1991.

Teramoto K, Baquerizo A, Imagawa DK, Olthoff KM, Dempsey RA, Busuttil RW. Prolongation of hepatic allograft survival in rat recipients treated with anti-lymphotoxin antibody. Transplantation Proceedings 23: 602, 1991.

Seu P, Imagawa DK, Olthoff KM, Wasef E, Dempsey RA, Busuttil RW. Synergistic enhancement of rat cardiac allograft survival with monoclonal anti-tumor necrosis factor antibody and low-dose cyclosporine. Journal of Surgical Research 50(5): 520-528, May 1991.

Olthoff KM, Wasef E, Seu P, Imagawa DK, Freischlag JA, Hart J, Busuttil RW. PGE1 reduces injury in hepatic allografts following preservation. Journal of Surgical Research 50(6): 595-601, June 1991.

McDiarmid SV, Hall TR, Grant EG, Milewicz AL, Olthoff KM, Lois J, Vargas J, Ament ME, Busuttil RW: Failure of duplex sonography to diagnose hepatic artery thrombosis in high risk group of pediatric liver transplant recipients. Journal of Pediatric Surgery 26(6): 710-713, June 1991.

Jurim O, Csete M, Gelabert HA, Millies JM, Olthoff KM, Imagawa D, Shaked A, McDiarmid SV, Busuttil RW. Reduced-size grafts--the solution for hepatic artery thrombosis after pediatric liver transplantation?. Journal of Pediatric Surgery 30(1):53-55, Jan. 1995.

Millis JM, Imagawa DK, Olthoff KM, Martin P, Gomes A, Shaked A, Yersiz H, Drazen K, Goldstein LI, Busuttil RW. TIPS: Impact on liver transplantation. Transplantation Proceedings 27(1): 1252-1253, Feb. 1995.

Jurim O, Shackleton CR, McDiarmid SV, Martin P, Shaked A, Millis JM, Imagawa DK, Olthoff KM, Maxfield A, Pakrasi AL, Melinek J, Ament M, Vargas J, Goldstein LK, Busuttil RW. Living-donor liver transplantation at UCLA. American Journal of Surgery 169(5): 529-532, May 1995.

Moldovan S, Atiya A, Adrian T, Kleinman R, Lloyd K, Olthoff KM, Imagawa D, Shevlin L, Coy D, Walsh J, Brunicardi F. Somatostatin inhibits B-cell secretion via a subtype-2 somatostatin receptor in the isolated perfused human pancreas. Journal of Surgical Research 59(1):85-90, July 1995.

Drazan KE, Wu L, Olthoff KM, Jurim O, Busuttil RW, Shaked A. Transduction of hepatic allografts achieves local levels of viral IL-10 which suppress alloreactivity in vitro. Journal of Surgical Research 59(1):219-223, July 1995.

Farmer DG, Shaked A, Olthoff KM, Imagawa DK, Millis JM, Busuttil RW. Evaluation, operative management and outcome after liver transplantation in children with biliary atresia and situs inversus. Annals of Surgery 222(1):47-50, July 1995.

Shackleton C, Martin P, Melinek J, Stothers L, Millis JM, Olthoff KM, Imagawa DK, Kinkhabwala M, Rudich S, Seu P, Shaked A, McDiarmid SV, Goldstein LI, Busuttil RW. Lack of correlation between the magnitude of preservation injury and the incidence of acute rejection, need for OKT3 or conversion to FK506 in cyclosporine treated primary liver allograft recipients. Transplantation 60(6):554-558, Sept. 1995.

Shackleton CR, Jurim O, McDiarmid SV, Martin P, Shaked A, Maxfield A, Pakrasi AL, Melinek J, Ament M, Vargas J, Millis JM, Imagawa DK, Olthoff KM, Goldstein LI, Busuttil RW. Living donor liver transplantation: Potential treatment of choice for pediatric recipients. American Journal of Surgery 169:529-532, 1995.

Kleinman R, Gingerich R, Ohning G, Wong H, Olthoff K, Walsh J, Brunicardi RC. The influence of somatostatin on glucagon and pancreatic polypeptide secretion in the isolated perfused human pancreas. International Journal of Pancreatology 18(1):51-77, Aug. 1995.

Yersiz H, Shaked A, Olthoff KM, Imagawa DK, Shackleton C, Martin P, Busuttil RW. Correlation between donor age and the pattern of liver graft recovery after transplantation. Transplantation 60(8):790-794, Oct. 27, 1995.

Drazan KE, Shaked A, Olthoff KM, Imagawa D, Jurim O, Kiai K, Shackleton C, Busuttil RW. Etiology and management of adult hepatic artery thrombosis after orthotopic liver transplantation. American Surgeon 62(3):237-240, March 1996.

Imagawa DK, Olthoff KM, Hasan Y, Shackleton CR, Colquhoun SD, Shaked A, Busuttil RW. Rapid en bloc technique for pancreas-liver procurement. Transplantation 61(11):1605-1609, June 15, 1996.

Seu P, Imagawa DK, Olthoff KM. A prospective study on the reliability and cost effectiveness of preoperative ultrasound screening of the “marginal” liver donor. Transplantation 62(1):129-130, July 15, 1996.

Seu P, Shackleton CR, Shaked A, Imagawa DK, Olthoff KM, Rudich ST, Kinkhabwala J, Busuttil RW. Improved results of liver transplantation in patients with portal vein thrombosis. Archives of Surgery 131(8):840-845, Aug. 1996.

Seu P, Olthoff KM, Rudich S, Kinkhabwala M, Imagawa DK, Neelankanta G, Goldstein LI, Martin P, Shackleton CR, Shaked A, Busuttil RW. Liver transplantation for fulminant hepatic failure in a Jehovah’s Witness. Clinical Transplantation 10(5):404-407, Oct. 1996.

Drazan KE, Olthoff KM, Wu L, Xiu-Da S, Gelman A, Shaked A. Adenovirus-mediated gene transfer in the transplant setting: Early events after orthotopic transplantation of liver allografts expressing TGF- 1. Transplantation 62(8):1080-1084, Oct. 27, 1996.

Farmer DB, Shaked A, McDiarmid SV, Olthoff KM, Imagawa KD, Millis JM, Robert ME, Lewin K, Goldstein LI, Busuttil RW. Small intestine transplantation: The University of California Los Angeles Experience. Transplantation Proceedings 28(5):2746-2747, Oct. 1996.

Millis M, Melinek J, Csete M, Imagawa DK, Olthoff KM, Neelankanta G, Braunfeld MYC, Sopher MJ, Chan SM, Pregler JL, Yersiz H, Busuttil AA, Shackleton CR, Shaked A, Busuttil RW. Randomized controlled trial to evaluate flush and reperfusion techniques in liver transplantation. Transplantation 63(3):397-403, Feb. 15, 1997.

Sellers M, Singer A, Maller E, Olthoff K, Jacobowski D, Shaked A. Incidence of late acute rejection and progression to chronic rejection in pediatric liver recipients. Transplantation Proceedings 29(1-2) 428-429, Feb./March 1997.

Shaked A, Olthoff KM, Sellers M, Chen XD, Gelman A. Tolerance to a second donor-matched allograft following local immune modulation using transfer of sequences encoding CTLA4Ig. Transplantation Proceedings 29(1-2):1026, Feb./March 1997.

Olthoff KM, Da Chen X, Gelman A, Turka L, Shaked A: Adenovirus-mediated gene transfer of CTLA4Ig to liver allografts results in prolonged survival and local T-cell anergy. Transplantation Proceedings 29(1-2):1030-1031, Feb./March 1997.

Olthoff KM, Judge TA, Gelman A, Chen XD, Hancock WW, Linsley PS, Turka LA, Shaked A: Adenovirus-mediated gene transfer into cold-preserved liver allografts: Survival pattern and tolerance following transduction with CTLA4Ig. Nature Medicine 4(2):194-200, Feb. 1998.

Marcucci L, Shaked A, Maller ES, Rand EB, Hahn ES, Higuchi NH, Barker CF, Olthoff KM: Supraceliac aortic pseudoaneurysms following liver transplantation in infants. Transplantation 68(10):1617-1619, Nov. 27, 1999.

Zamir GA, Olthoff KM, Nunes FA, Markmann JF, Zeldin GA, Stewart CA, Weinreib RM, Rand EB, Maller ES, Lucey MR, Shaked A. Liver transplantation at the University of Pennsylvania and the Children's Hospital of Philadelphia. Clinical Transplants 4:223-9, 1999.

Komisarof JA, Olthoff K, Siegelman ES, Lawton TJ, Furth EE: Focal nodular hyperplasia contiguous with an echinococcal cyst. Gastroenterology 95(4):1078-1081, April 2000.

Pfau PR, Kochman ML, Lewis JD, Long WB, Lucey MR, Olthoff K, Shaked A, Ginsberg GG: Endoscopic management of postoperative biliary complications in orthotopic liver transplantation. Gastrointestinal Endoscopy 52(1):55-63, July 2000.

Lehrer MS, Ruchelli E, Olthoff KM, Rook AH: Successful reversal of recalcitrant hepatic allograft rejection by photopheresis. Liver Transplantation 6(5):644-647, Sept. 2000.

Zamir GA. Markmann JF. Abrams J. Macatee MR. Nunes FA. Shaked A. Olthoff KM. The fate of liver grafts declined for subjective reasons and transplanted out of a local organ procurement organization. Transplantation 70(8):1149-1154, Oct. 2000.

Debonera F, Aldeguer X, Shen S, Gleman AE, Gao F, Que X, Greenbaum LE, Furth EE, Taub R, Olthoff KM: Activation of IL-6STAT3 and liver regeneration following transplantation. Journal of Surgical Research 96(2):289-295, Apr. 2001.

Tsai DE, Hardy CL, Tomaszewski JE, Kotloff RM, Olthoff KM, Somer BG, Schuster SJ, Porter DL, Montone KT, Stadtmauer EA. Reduction in immunosuppression as initial therapy for post-transplant lymphoproliferative disorder: Analysis of prognostic variables and long-term follow-up of 42 adult patients. Transplantation 71(8):1076-1088, Apr. 27, 2001.

Steinman TI, Becker BN, Frost AE, Olthoff KM, Smart FW, Suki WM, Wilkinson AH: Guidelines for the referral and management of patients eligible for solid organ transplantation. Transplantation 71(9):1189-1204, May 15, 2001.

Zamir G, Gelman A, Debonera F, Hardwigsen J, Que X, Aldeguer X, Martin M, Shaked A, Olthoff KM: Modified AdCTLA-f vector blocks alloimmune response in-vitro. Journal of Surgical Research 97(2):155-158, May 15, 2001.

Singer AL, Olthoff KM, Kim H, Rand E, Zamir G, Shaked A. The role of plasmapheresis in the manage-ment of acute hepatic failure in the pediatric population. Annals of Surgery 234(3):418-424, Sept. 2001.

Velidedeoglu E, Desai NM, Campos L, Olthoff KM, Shaked A, Nunes F, Zeldin G, Stewart C, Blumberg E, Abrams J, Markmann JF. Effect of donor hepatitis C on liver graft survival. Transplantation Proceedings 33(7-8):3795-3796, Nov./Dec. 2001.

Olthoff KM, Gelman AE, Zamir GA, Debonera F, Krasinkas AM, Shen X, Gao F, Shaked A. Pattern of alloimmune response in second same donor allografts after induction of tolerance using CTLA4Ig. Transplantation 72(12):1952-1956, Dec. 27, 2001.

Aldeguer X, Debonera F, Shaked A, Krasinkas AM, Gelman AE, Que X, Zamir GA, Hiroyasu S, Kovalovich KK, Taub R, Olthoff KM. Interleukin-6 from intrahepatic cells of bone marrow origin is required for normal murine liver regeneration. Hepatology 35(1):40-48, Jan. 2002.

Shiffman ML, Brown RS Jr, Olthoff KM, Everson G, Miller C, Siegler M, Hoofnagle JH. Living donor liver transplantation: Summary of a conference at The National Institutes of Health. Liver Transplantation 8(2):174-188, Feb. 2002.

Velidedeoglu E, Desai NM, Campos L, Olthoff KM, Shaked A, Nunes F, Zeldin G, Stewart C, Blumberg E, Abrams J, Markmann JF. The outcome of liver grafts procured from hepatitis C-positive donors. Transplantation 73(4):582-587, Feb. 27, 2002.

Zamir G, Olthoff KM, Desai N, Markmann JF, Shaked A. Toward further expansion of the organ pool for adult liver recipients: Splitting the cadaveric liver into right and left lobes. Transplantation 74(12):1757-1761, Dec. 27, 2002.

Tsai DE, Nearey M, Hardy CL, Tomaszewski JE, Kotloff RM, Grossman RA, Olthoff KM, Stadtmauer EA, Porter DL, Schuster SJ, Luger SM, Hodinka RL. Use of EBV PCR for the diagnosis and monitoring of post-transplant lymphoproliferative disorder in adult solid organ transplant patients. American Journal of Transplantation 2(10):946-954, 2002.

Abt PL, Crawford MD, Desai NJ, Markmann J, Olthoff KM, Shaked A. Liver transplantation from controlled non-heart-beating donors: an increased incidence of biliary complications. Transplantation 75(10):1659-1663, May 27, 2003.

Hagen EA, Lautenbach E, Olthoff K, Blumberg EA. Low prevalence of colonization with vancomycin-resistant enterococcus (VRE) in patients awaiting liver transplantation. American Journal of Transplantation 3(7):902-905, July 2003.

Shah, JN, Haigh WG, Lee SP, Lucey MR, Brensinger C, Kochman ML, Long WB, Olthoff K, Shaked A, Ginsberg GG. Biliary casts following adult orthotopic liver transplantation: Clinical factors, treatment, and biochemical analysis. American Journal of Gastroenterology 98(8):1861-1867, Aug. 2003.

Debonera F, Krasinkas A, Aldequer X, Que X, Gelman A, Shaked A, Olthoff K. Dexamethasone inhibits the early regenerative response of the rat liver after cold preservation and transplantation. Hepatology 38(6):1563-1572. Dec. 2003.

Abt PL, Desai NJ, Crawford MD, Forman L, Markmann JW, Olthoff KM, Markmann JF. Survival following liver transplantation from non-heart beating donors. Annals of Surgery 239(1):87-92, Jan. 2004.

Weinrieb RM, Barnett R, Lynch KG, DePiano M, Atanda A, Olthoff KM. A matched comparison study of medical and psychiatric complications and anesthesia and analgesia requirements in methadone-maintained liver transplant recipients. Liver Transplantation 10(1):97-106, Jan. 2004.

Que X, Debonera F, Xie J, Furth EE, Aldeguer X, Gelman AE, Olthoff KM. Pattern of ischemia reperfusion injury in a mouse orthotopic liver transplant model. Journal of Surgical Research 116(2):262-268, Feb. 2004.

Velidedeoglu E, Bloom RD, Crawford MD, Desai NM, Campos L, Abt PL, Markmann JW, Mange KC, Olthoff KM, Shaked A, Markmann JF. Early kidney dysfunction post liver trans-plantation predicts late chronic kidney disease. Transplantation 77(4):553-556, Feb. 27, 2004.

Makuuchi M, Miller CM, Olthoff K, Schwartz M: Adult-adult living donor liver transplantation. Journal of Gastrointestinal Surgery 8(3):303-312, Mar./Apr. 2004.

Stewart CA, Wertheim J, Olthoff K, Furth EE, Brensinger C, Markmann J, Shaked A. Ascites after liver transplantation: A mystery. Liver Transplantation 10(5):654-660, May 2004.

Shetty K, Timmins K, Brensinger C, Furth EE, Rattan S, Sun W, Rosen M, Soulen M, Shaked A, Reddy KR, Olthoff KM. Liver transplantation for hepatocellular carcinoma: Validation of present selection criteria in predicting outcome. Liver Transplantation 10(7):911-918, July 2004.

Shah JN, Ahmad NA, Shetty K, Kochman ML, Long WB, Brensinger CM, Pfau PR, Olthoff K, Markmann J, Shaked A, Reddy KR, Ginsberg GG. Endoscopic management of biliary complications after adult living donor liver transplantation. American Journal of Gastroenterology 99(7):1291-1295, July 2004.

Abt PL, Mange KC, Olthoff KM, Markmann JF, Reddy KR, Shaked A. Allograft survival following adult-to-adult living donor liver transplantation. American Journal of Transplantation 4(8):1302-1307, Aug. 2004.

Abt P, Mange K, Olthoff K, Reddy R, Shaked A. Survival among pediatric liver transplant recipients: Impact of segmental grafts. Transplantation 10(10):1287-1293, Oct. 2004.

Zamir G, Gelman AE, Olthoff KM, Debonera F, Aldeguer X, Shaked A. Patterns of transgene expression and viral clearance from the transplanted liver following ex vivo adenovirus-mediated gene transfer. Journal of Hepatology 41(5):714-720, Nov. 2004.

Porrett PM, Desai SS, Timmins KJ, Twomey CR, Sonnad SS, Olthoff KM. Combined orthotopic heart and liver transplantation: The need for exception status listing. Liver Transplantation 10(12):1539-1544, Dec. 2004.

Debonera F, Wang G, Xie J, Gelman A, LeClair C, Xin D, Shaked A, Olthoff KM. Severe preservation injury induces II-6/STAT3 activation with lack of cell cycle progression after partial liver graft transplantation. American Journal of Transplantation 4(12):1964-1971, Dec. 2004.

Hanto DW, Fishbein TM, Pinson CW, Olthoff KM, Shiffman ML, Punch JD, Goodrich NP. Liver and intestine transplantation: Summary Analysis, 1994-2003. American Journal of Transplantation 5(4 Part 2):916-933, Apr. 2005.

Campbell MS, Kotlyar DS, Brensinger CM, Lewis J, Shetty K, Bloom RD, Markmann JF, Olthoff KM, Shaked A, Reddy KR. Renal function after orthotopic liver transplantation is predicted by duration of pre-transplantation creatinine elevation. Liver Transplantation 11(9):1048-1055, Sept. 2005.

Olthoff KM, Merion RM, Ghobrial RM, Abecassis MM, Fair JH, Fisher RA, Freise CE, Kam I, Pruett TL, Everhart JE, Hulbert-Shearon TE, Gillespie BW, Emond JC, A2ALL Study Group. Outcomes of 385 adult-to-adult living donor liver transplant recipients: a report from the A2ALL Consortium. Annals of Surgery 242(3):314-325, Sept. 2005.

Tsai DE, Aqui NA, Tomaszewski JE, Olthoff KM, Ahya VN, Kotloff RM, Bloom RD, Brozena SC, Hodinka RL, Stadtmauer EA, Schuster SJ, Nasta SD, Porter DL, Luger SM, Klumpp TR. Serum protein electrophoresis abnormalities in adult solid organ transplant patients with post-transplant lymphoproliferative disorder. Clinical Transplants 19(5):644-652, Oct. 2005.

Abt PL, Abdullah I, Korenda K, Frank A, Peterman H, Stephenson GR, Markmann JF, Shaked A, Olthoff KM. Appendicitis among liver transplant recipients. Liver Transplantation 11(10):1282-1284, Oct. 2005.

Canter RJ, Abt PL, Litzky LA, Frank A, Abt AB, Sellers MT, Markmann JF, Olthoff KM, Naji A, Shaked A. Successful liver, kidney, and pancreas transplantation from a donor with cerebral emboli from a left atrial myxoma. Transplantation Proceedings 37(10):4334-4336, Dec. 2005.

Elstrom RL, Andreadis C, Aqui NA, Ahya VN, Bloom RD, Brozena SC, Olthoff KM, Schuster SJ, Nasta SD, Stadtmauer EA, Tsai DE. Treatment of PTLD with rituximab or chemotherapy. American Journal of Transplantation 6(3):569-576, Mar. 2006.

Porrett PM, Peterman H, Rosen M, Sonnad S, Soulen M, Markmann JF, Shaked A, Furth E, Reddy KR, Olthoff K. Lack of benefit of pre-transplant locoregional hepatic therapy for hepatocellular cancer in the current MELD era. Liver Transplantation 12(4):665-673, Apr. 2006.

Rand EB, Bunin N, Cochran W, Ruchelli E, Olthoff KM, Bloomer JR. Sequential liver and bone marrow transplantation for treatment of erythropoietic protoporphyria. Pediatrics 118(6):e1896-1899, Dec. 2006.

Xie JF, Wang G, Debonera F, Han R, Dorf ME, Hancock W, Olthoff KM. Selective neutralization of the chemokine TCA3 reduces the increased injury of partial versus whole liver transplants induced by cold preservation. Transplantation 82(11):1501-1509, Dec. 15, 2006.

Abt P, Kashyap R, Orloff M, Jain A, Tsoulfas G, Bozorgzadeh A, Olthoff K. Pediatric liver and kidney transplantation with allografts from DCD donors: A review of UNOS data. Transplantation 82(12):1708-1711, Dec. 27, 2006.

Fisher RA, Kulik LM, Freise CE, Lok ASF, Shearon TH, Brown Jr. RS, Ghobrial RM, Fair JH, Olthoff KM, Kam I, Berg CL, A2ALL Study Group. Hepatocellular carcinoma recurrence and death following living and deceased donor liver transplantation: The A2ALL Study. American Journal of Transplantation 2007 (accepted for publication).

Zamir G, Zeira E, Gelman AE, Shaked A, Olthoff KM, Eid A, Galun E. Replication-deficient adenovirus induces host topoisomerase 1 activity: Implications for adenovirus-mediated gene expression. Molecular Therapy 2007 (in press).

Reviews in Peer-Review Research Publications
Olthoff KM, Millis JM, Rosove MH, Goldstein LI, Ramming KP, Busuttil RW: Is liver transplantation justified for the treatment of hepatic malignancies? [Review] Archives of Surgery 125(10): 1261-1268, Oct. 1990.

Colonna JO, Olthoff KM, Seu P, Busuttil RW: Liver resections for primary neoplasms. [Review] Advances in Surgery 25: 309-329, 1992.

Farmer DG, Shaked A, Colonna JO, Olthoff KM, Jurim O, Colquhoun S, Millis JM, Busuttil RW. Radical resection combined with liver transplantation for foregut tumors. [Review] American Surgeon 59(12):806-812, Dec. 1993.

Olthoff KM, Rosove MH, Imagawa DK, Shackleton CR, Farmer D, Martin P, Goldstein LI, Shaked A, Busuttil RW. Adjuvant chemotherapy improves survival following liver transplantation for hepatocellular carcinoma. [Review] Annals of Surgery 221(6):734-743, June 1995.

Shaked A, Nunes FA, Olthoff KM, Lucey MR: Assessment of liver function: Pre-and peri-transplant evaluation. [Review] Clinical Chemistry 43(8 Pt 2):1539-1545, Aug. 1997.

Weber M, Deng S, Olthoff K, Naji A, Barker CF, Shaked A, Brayman KL. Organ trans-plantation in the twenty first century. [Review] Urology Clinics of North America 25(1):51-61, Feb. 1998.

McDiarmid SV, Millis MJ, Olthoff KM, So SK: Indications for pediatric liver transplantation. [Review] Pediatric Transplantation 2(2):106-116, May 1998.
8. Olthoff KM: Surgical options for hepatocellular carcinoma: Resection and transplanta-tion.[Review] Liver Transplantation Surgery 4(5 Suppl 1):S98-S104, Sept. 1998.

Razek T, Olthoff K, Reilly PM: Issues in potential organ donor management. [Review] In: Schwab CW, and Reilly PM, Guest Ed. Surgical Clinics of North America. 80(3):1021-1032, June 2000.

Olthoff KM. Molecular pathways of regeneration and repair after liver transplantation. [Review] World Journal of Surgery 26(7):831-837, July 2002.

Rand EB, Olthoff KM. Overview of pediatric liver transplantation. [Review] Gastroenterology Clinics of North America 32(3):913-929, Sept. 2003.

Olthoff KM. Hepatic regeneration in living donor liver transplantation. [Review] Liver Transplantation 9(10):S35-S41, Oct. 2003.

Research Publications, Non-Peer-Reviewed
Olthoff KM and Busuttil RW: Portal decompression vs. sclerotherapy for bleeding esophageal varices. Surgical Rounds 13 (10): 33-43, 1990.

Seu P, Winston DJ, Olthoff KM, Bruckner DA, Busuttil RW: Legionnaires' disease in liver transplant recipients. Infectious Disease in Clinical Practice 2: 109-113, 1993.

Jurim O, Martin P, Winston DJ, Shackleton C, Holt C, Feller J, Csete M, Shaked A, Imagawa D, Olthoff KM, Lau JYN, Busuttil RW: Failure of ganciclovir prophylaxis to prevent allograft reinfection following orthotopic liver transplantation for chronic hepatitis B infection. Liver Transplantation Surgery 2(5):370-374, Sept. 1996.

Holt CD, Winston DJ, Kubak B, Imagawa DK, Martin P, Goldstein L, Olthoff KM, Millis JM, Shaked A, Shackleton CR, Busuttil RW: Coccidioidomycosis in liver transplant patients. Clinical Infectious Disease 24(2):216-221, Feb. 1997.

Tsai DE, Nearey M, Hardy CL, Tomaszewski JE, Kotloff RM, Grossman RA, Olthoff KM, Stadtmauer EA, Porter DL, Schuster SJ, Luger SM, Hodinka RL. Use of EBV PCR for the diagnosis and monitoring of post-transplant lymphoproliferative disorder in adult solid organ transplant patients. American Journal of Transplantation 2(10):946-954, 2002.

Olthoff KM. Molecular pathways of regeneration and repair in liver transplantation. World Journal of Surgery 26:831-837, 2002.

Rand EB, Olthoff KM. Pediatric liver transplantation. Graft 6(2):145-150, 2003.

Abstracts (last 3 years)
Gelman AE, Abt P, Xin D, Wang G, Debonera F, Olthoff K, Wells A, Shaked A. CTLA4IG immunosuppression allows preservation of CD8+ T cell memory response to tumor antigens: A potential advantage in the transplant setting. American Journal of Transplantation 4(8):191, 2004.

Stephenson GR, Abt P, Frank A, Kaminsky M, Shaked A, Markmann J, Olthoff KM. Successful trans-plantation of livers from older cadaveric donors. American Journal of Transplantation 4(8):518, 2004.

Marin H, Soulen MC, Clark TW, Tuite CM, Furth EE, Olthoff K. Histopathologic outcome of neoadjuvant image-guided therapy of hepatocellular carcinoma. JVIR 15(2part2):S214-215, 2004.

Porrett PM, Sonnad S, Timmins K, Rosen M, Soulen M, Shaked A, Furth E, Olthoff K. Pretransplant locoregional ablative therapy for CHH may not provide beneficial effect in the current MELD era. Hepatology 40(4):194A, 2004. Presented for “Hot Topics in Hepatology” oral session at AASLD.

Xie J, Wang G, Debonera F, LeClair C, Xin D, De Jonge J, Gelman A, Shaked A, Olthoff K. Il-6 inhibits apoptotic mechanisms and promotes graft survival after liver transplantation. American Journal of Transplantation 5(Supp 11):432, 2005.

Leclair C, Xin D, Wang G, Xie J, Debonera F, de Jonge J, Shaked A, Olthoff K. Insulin-like growth factor binding protein-1 is critical for glucose homeostasis and recovery after small-for-size liver transplantation. American Journal of Transplantation 5(Supp.11):515, 2005.

Porrett P, Cohen M, Keller D, Sonnad S, Kurichi J, Goodsell C, Markmann JF, Shaked A, Olthoff K. Impact of center experience on pediatric liver segmental graft outcome. American Journal of Transplantation 5(Supp. 11):526, 2005.

Rand EB, Goodsell C, Olthoff KM, Shaked A. Sirolimus monotherapy experience in pediatric liver transplant recipients. American Journal of Transplantation 5(Supp 11):527, 2005.

Xie J, Wang G, Debonera F, LeClair C, Dong X, De Jonge J, Gelman A, Han R, Dorf ME, Shaked A, Hancock W, Olthoff KM. ANTI-TCA-3 monoclonal antibody treatment reduces the cold preservation injury in a mouse 50% liver transplant model. American Journal of Transplantation 5(Suppl 11):566, 2005.

deJonge J, Kurian S, Salomon DR, Tilanus HW, vanderLan L, Olthoff K. Gene expression profile of regeneration in human living-donor liver transplantation. Liver Transplantation 12:(5 Supp 1):C-38, 2006.

Freise CE, Gillespie BW, Koffron AJ, Lok AS, Pruett TL, Emond JC, Fair JH, Fisher RA, Olthoff KM, Trotter JF, Ghobrial RM, A2ALL Study Group. Comparison of complication rates in recipients of living donor and deceased donor liver transplants: findings from the adult-to-adult living donor liver Transplantation Cohort Study. Hepatology 44(Suppl 10):124A, 2006.

Merion RM, Goodrich NP, Freeman Jr. RB, Olthoff KM, Edwards EB, Wiesner Jr. RH, McDiarmid SV. Impact of a regional allocation rule for high MELD/PELD liver transplant candidates. Liver Transplantation 12(5 Supp 1):C-103, 2006.

Ghobrial RM, Freise CE, Trotter JF, Tong L, Ojo AO, Fair JH, Fisher RA, Kinkhabwala MM, Koffron AJ, Pruett TL, Olthoff KM. Donor morbidity and mortality of adult living donors for liver transplantation. American Journal of Transplantation 6(Suppl 2), Aug. 2006.

Porrett P, Yeh H, Korenda K, Rivera T, Pfeiffenberger P, Shaked A, Markmann JF, Olthoff KM. Similarity in liver transplant outcomes between older and younger adult recipients. American Journal of Transplantation 6(Suppl 2), Aug. 2006.

Tsai D, Douglas L, Andreadis C, Svoboda J, Arnoldi S, Bloom R, Olthoff K, Brozena S, Schuster S, Stadtmauer S, Kotloff R, Ahya V. Two-arm prospective trial evaluating the ability of a novel EBV PCR panel to diagnose and monitor post-transplant lymphoproliferative disorder. American Journal of Transplantation 6(Suppl 2), Aug. 2006.

Debonera F, Eaton M, Xie JF, Furth E, KM Olthoff. Insulin growth factor binding protein 1 is important for normal glucose metabolism and energy output under stress. Academic Surgical Congress, Phoenix AZ, Feb. 2007; Journal of Surgical Research 137(2), Feb. 2007.

Olthoff K, Christie J, Samstein B, Kulik L, Shaked A, Abecassis M, Emond J. Validity of the definition of early allograft dysfunction in liver transplant recipients. American Journal of Transplantation 7(5), 2007.

Olthoff K, Kulik L, Samstein B, Kaminski M, Abecassis M, Emond J, Shaked A, Cristie J. Risk factors for developing early allograft dysfunction following liver transplantation. American Journal of Transplantation 7(5), 2007.

Olthoff K, Kurian S, deJonge J, Shaked A, Salomon D. Unique gene expression patterns in brain dead deceased donor liver grafts at time of procurement. American Journal of Transplantation 7(5)5, 2007.

Xie J, Han R, Debonera F, Hahcock W, Olthoff, K. IP-10 is important for liver ischemia reperfusion injury but is not required for liver regeneration. American Journal of Transplantation 7(5), 2007.

Editorials, Chapters & Participation in Committee Reports
Millis JM, Olthoff KM, Imagawa DK, Baquerizo A, Busuttil RW: Liver transplantation at UCLA: A report of clinical activities. In Terasaki, PI (ed.): Clinical Transplants 1988. Los Angeles: UCLA Tissue Typing Laboratory, 1988, 29-34.

Olthoff KM, Brown SL, Busuttil RW: Portal hypertension. In Moore WS (ed.): Vascular Surgery: A Comprehensive Review, Third Edition. Orlando: W.B. Saunders Co., 1990.

Olthoff KM and Busuttil RW: Liver transplantation in the management of portal hypertension. In Ernst CB and Stanley JC (eds.): Current Therapy in Vascular Surgery, Third Edition. Philadelphia: Mosby-Year Book, Inc., 1995, 755-759.

Olthoff KM and Busuttil RW: Venous anomalies including portal vein thrombosis and prior portosystemic shunts. Chapter 46 in Busuttil RW and Klintmalm GB (eds.): Transplantation of the Liver. Philadelphia: W.B. Saunders Co., 1996, 46-47.

Olthoff KM, Rosove MH, Shackleton CR, Imagawa DK, Farmer DG, Northcross P, Pakrasi AL, Martin P, Goldstein LI, Shaked A, Busuttil RW: Continuous infusional 5-fluorouracil chemotherapy. [Letter] Annals of Surgery 224(5):686, Nov. 1996.

Olthoff KM: Cadaver liver donor selection criteria. In Norman and Turka (eds.): Primer on Trans-plantation, Second Edition. Thoroughfare, NJ: American Society of Transplant Physicians, 1999.

Zamir GA, Olthoff KM, Nunes FA, Markmann JF, Zeldin GA, Stewart CA, Weinreib RM, Rand EB, Maller ES, Lucey MR, Shaked A: Liver transplantation at the University of Pennsylvania and the Children's Hospital of Philadelphia. Chap. 20 in Cecka and Terasaki (eds.): Clinical Transplants 1999. Los Angeles: UCLA Tissue Typing Laboratory, 1999, 223-229.

Nunes, FA, Olthoff KM, Lucey MR: Liver transplantation: Indications and pretransplant evaluation. Chap. 31 in Bacon B and DiBisceglie (eds.): Liver Disease: Diagnosis and Management, First Edition. Philadelphia: Churchill-Livingstone, 2000, 383-391.

Olthoff KM: Cadaver liver donor selection criteria. Chap. VII in: Norman and Turka, Ed. Primer on Transplantation, 2nd Edition. Mt. Laurel, NJ: American Society of Transplantation, 2001, 536-539.

Zamir G, Olthoff KM, Shaked A: Gene therapy and graft modification. Current Opinion in Organ Transplantation 6(4):113-117, 2001.

Olthoff KM. Can reperfusion injury of the liver be prevented? Trying to improve on a good thing. Pediatric Transplantation 5(6):390-393, Dec. 2001.

Barker CF, Brayman KL, Markmann JF, Naji A, Olthoff KM, Shaked A. Transplantation of abdominal organs. Chap. 25 in: Beauchamp, Evers, Matton, Eds. Sabiston Textbook of Surgery, 16th Edition. Philadelphia: WB Saunders Co., 2001, 429-470.

Rand E, Olthoff KM. Pediatric liver transplantation. Chap. 10 in: Lucey M. Neuberger J, Shaked A, Eds. Liver Transplantation. Georgetown, TX: Landes Bioscience, 2002, 109-115.

Olthoff, KM, Abt, PL, Shaked A. Liver transplantation. Reddy KR, Long WB, Eds. Requisites in Gastroenterology. 3:243-255, 2004.

Markmann JF, Brayman KL, Naji A, Olthoff KM, Shaked A, Barker CF. Transplantation of abdominal organs. Chap. 27 in: Townsend, Beauchamp, Evers, Mattox, Eds. Sabiston Textbook of Surgery, 17th Edition. Philadelphia: WB Saunders Co., 2004, 699-755.

Olthoff KM, Brown RS Jr, Delmonico FL, Freeman RB, McDiarmid SV, Merion RM, Millis JM, Roberts JP, Shaked A, Wiesner RH, Lucey MR. Summary report of a national conference: Evolving concepts in liver allocation in the MELD and PELD era. Dec. 8, 2003, Washington, DC, USA. [Congresses] Liver Transpl 10(10 Suppl 2):A6-22, Oct. 2004.

Desai NM, Olthoff KM. Portal vein thrombosis and other venous anomalies in liver transplantation. In Busuttil RW, Klintmalm GB, Eds. Transplantation of the Liver, 2nd Edition. Philadelphia: WB Saunders, 2005, 743-754.

Olthoff K. Liver regeneration: Clinical relevance. In Blumgart LH, DeMatteo RP, Eds. Surgery of the Liver, Biliary Tract and Pancreas, 4th Edition. Philadelphia: WB Saunders, 2006, 54-62.

Olthoff K, Markmann J. The role of re-transplantation. In Schiff ER, Sorrell MF, Maddrey WC, Eds. Schiff's Diseases of the Liver, 10th Edition. Philadelphia: Lippincott Williams & Wilkins, 2007 (in press).

DeJonge J, Olthoff KM. Liver transplantation: Liver regeneration. In Gruessner RWG, Ed. Living Donor Organ Transplantation. New York: Elsevier, 2007 (in press).

Alternative Media
Presenter in the Baylor CME Website for “The Molecular Surgeon” symposium www.baylorcme.org/onlinecme/molecsurg/pres_overview.html# (“Molecular Pathways of Injury and Repair in Liver Transplantation”).

Olthoff K: Lifetime TV Series: “Women Docs: A Critical Difference.” March 27, 2002.

Editor/screenwriter for liver transplant educational videotape/DVD A Living Donor Story, 2003.

 


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