Dr. Adzick, Chief of Pediatric Surgery, is interested in all aspects of pediatric general, thoracic, and fetal surgery. He has particular interest in clinical applications of fetal diagnosis and therapy. This experimental and clinical research is focused on the prenatal diagnosis, natural history, and management of the fetus with a surgically correctable defect. At The Center for Fetal Diagnosis and Treatment at The Children’s Hospital of Philadelphia, we are pursuing fetal surgical treatment of life-threatening fetal anatomic malformations such as urethral obstruction, diaphragmatic hernia, cystic adenomatoid malformation of the lung, and sacrococcygeal teratoma. We are also pursuing the prenatal treatment of a variety of a cellular deficiency diseases by performing hematopoietic stem cell transplantation in utero. This enterprise requires study of the efficacy, safety, and cost-effectiveness of fetal intervention, as well as ongoing experimental work in fetal animal models.