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Sunil Singhal, M.D.
Thoracic Surgery
 
Research Publications, Peer Reviewed
  1. Singhal S, Ratner LE. Unilateral renal agenesis with pelvic renal ectopy. Journal of the American College of Surgeons 193(3):330, Sept. 2001.
  2. Singhal S, Amin KM, Kruklitis R, DeLong P, Friscia ME, Litzky LA, Putt ME, Kaiser LR, Albelda SM. Alterations in cell cycle genes in early stage lung adenocarcinoma identified by expression profiling. Cancer Biology & Therapy 2(3):291-298, May/June 2003.
  3. Perkowski S, Sun J, Singhal S, Santiago J, Leikauf GD, Albelda SM. Gene expression profiling of the early pulmonary response to hyperoxia in mice. American Journal of Respiratory Cell & Molecular Biology 28(6):682-696, June 2003.
  4. Singhal S, Kyvernitis CG, Johnson SW, Kaiser LR, Liebman MN, Albelda SM. Micro-array data simulator for improved selection of differentially expressed genes. Cancer Biology & Therapy 2(4):383-391, July/Aug. 2003.
  5. Singhal S, Wiewrodt R, Malden LD, Amin KM, Matzie K, Friedberg J, Kucharczuk JC, Litzky LA, Johnson SW, Kaiser LR, Albelda SM. Gene expression profiling of malignant mesothelioma. Clinical Cancer Research 9(8):3080-3097, Aug. 1, 2003.
  6. Singhal S, Amin KM, Kruklitis R, Marshall MB, Kucharczuk JC, DeLong P, Litzky LA, Kaiser LR, Albelda SM. Differentially expressed apoptotic genes in early stage lung adenocarcinoma predicted by expression profiling. Cancer Biology & Therapy 2(5):566-571, Sept./Oct. 2003.
  7. Singhal S, Shrager JB, Rosenthal DI, LiVolsi VA, Kaiser LR. Comparison of stages I-II thymoma treated by complete resection with or without adjuvant radiation. Annals of Thoracic Surgery 76(5):1635-1642, Nov. 2003.
  8. Cook JW, Sterman DH, Singhal S, Smythe WR, Kaiser LR. Suramin inhibits the growth of malignant mesothelioma in vitro, and in vivo, in murine flank and intraperitoneal models. Lung Cancer 42(3):263-274, Dec. 2003.
  9. Paulson EC, Singhal S, Kucharczuk JC, Sterman DH, Kaiser LR, Marshall MB. Bronchial sleeve resection for posttransplant stricture. Annals of Thoracic Surgery 76(6):2075-2076, Dec. 2003.
  10. Kruklitis RJ, Singhal S, Delong P, Kapoor V, Sterman DH, Kaiser LR, Albelda SM. Immuno-gene therapy with interferon-beta before surgical debulking delays recurrence and improves survival in a murine model of malignant mesothelioma. Journal of Thoracic & Cardiovascular Surgery 127(1):123-130, Jan. 2004.
  11. O'Donnell RK, Kupferman M, Wei SJ, Singhal S, Weber R, O'Malley B, Cheng Y, Putt M, Feldman M, Ziober B, Muschel RJ. Gene expression signature predicts lymphatic metastasis in squamous cell carcinoma of the oral cavity. Oncogene 24(7):1244-1251, Feb. 10, 2005.
  12. Wade KC, Guttentag SH, Gonzales LW, Maschhoff KL, Gonzales J, Kolla V, Singhal S, Ballard PL. Gene induction during differentiation of human pulmonary type II cells in vitro. American Journal of Respiratory Cell & Molecular Biology 34(6):727-737, June 2006.
  13. Nathan H, Singhal S, Cameron JL. Benign pneumatosis intestinalis in the setting of celiac disease. Journal of Gastrointestinal Surgery 10(6):890-894, June 2006.
  14. Singhal S, Cooper JM, Cheung AT, Acker MA. Images in cardiovascular medicine: Rib perforation from a right ventricular pacemaker lead. Circulation 115(14):e391-392, Apr. 10, 2007.
 
Research Publications, Peer Reviewed
  1. Vachani A, Nebozhyn M, Singhal S, Alila L, Wakeam E, Muschel R, Powell CA, Gaffney P, Singh B, Brose MS, Litzky LA, Kucharczuk J, Kaiser LR, Marron JS, Showe MK, Albelda SM, Showe LC. A 10-gene classifier for distinguishing head and neck squamous cell carcinoma and lung squamous cell carcinoma. Clinical Cancer Research 13(10):2905-2915, May 15, 2007.
  2. Fabre D, Fadel E, Singhal S, de Montpreville V, Mussot S, Mercier O, Chataigner O, Dartevelle PG. Complete resection of pulmonary inflammatory pseudotumors has excellent long-term prognosis. Journal of Thoracic & Cardiovascular Surgery 137(2):435-440, Feb. 2009.
 
Reviews in Peer Reviewed Research Publications
  1. Singhal S, Kaiser LR. Cancer chemotherapy using suicide genes. [Review] Surgical Oncology Clinics of North America 7(3):505-536, July 1998.
  2. Singhal S, Johnson CA, Udelsman R. Primary hyperparathyroidism: What every orthopedic surgeon should know. [Review] Orthopedics 24(10):1003-1011, Oct. 2001.
  3. Singhal S, Kaiser LR. Malignant mesothelioma: options for management. [Review] Surgical Clinics of North America 82(4):797-831, Aug. 2002.
  4. Greenberg J, Singhal S, Kaiser LR. Giant bullous disease: Evaluation, selection, techniques & outcomes. [Review] Chest Surgery Clinics of North America 13(4):631-650, Nov. 2003.
  5. Lee LS, Singhal S, Brinster CJ, Marshall B, Kochman ML, Kaiser LR, Kucharczuk JC. Current management of esophageal leiomyoma. [Review] Journal of the American College of Surgeons 198(1):136-146, Jan. 2004.
  6. Brinster CJ, Singhal S, Lee L, Marshall MB, Kaiser LR, Kucharczuk JC. Evolving options in the management of esophageal perforation. [Review] Annals of Thoracic Surgery 77(4):1475-1483, Apr. 2004.
  7. Singhal S, Vachani A, Antin-Ozerkis D, Kaiser LR, Albelda SM. Prognostic implications of cell cycle, apoptosis, and angiogenesis biomarkers in non-small cell lung cancer: a review. [Review] Clinical Cancer Research 11(11):3974-3986, June 1, 2005.
  8. Singhal S, Miller D, Ramalingam S, Sun SY. Gene expression profiling of non-small cell lung cancer. [Review] Lung Cancer 60(3):313-324, June 2008.
 
Editorials, Chapters & Participation in Committee Reports
  1. Singhal S, Machtay M, Kaiser LR. Malignant mesothelioma. Chap. 19 in Torosian M. (ed): Integrated Cancer Management. New York: Marcel Dekker Publ., 1999, 477-523.
  2. Singhal S, Kaiser LR. Multimodality therapy for non-small cell lung cancer. In Shields TW, LoCicero J, Ponn RB (eds): General Thoracic Surgery 5th Edition. Philadelphia: Lippincott Williams & Wilkins, 2000, I:XV(106):1415-1442.
  3. Singhal S, Kaiser LR. Benign and malignant mesothelioma. Chap. 22 in Bland KI, Daly JM, Karakousis CP (eds): Surgical Oncology: Contemporary Principles & Practice. New York: 2001, 1069-1102.
  4. Singhal S, Shrager JB, Kaiser LR. Biological treatments for lung cancer. In Sculier JP, Fry WA (eds): Clinique des Soins Intensifs Oncologiques et de Cancerologie Pulmonaire. Bruxelles, France: Researu Iris, 11(1):56-59, 2003.
  5. Singhal S. Thoracic surgery. Chap. 19 in Makary MA (ed): General Surgery Review. Washington: Ladner-Drysdale, 2004, 197-214.
  6. Singhal S, Yang S. Lung volume reduction surgery: Median sternotomy approach. Sect. 11, Chap. 75 in Yang S, Cameron D (eds): Current Therapy in Thoracic and Cardiovascular Surgery. Philadelphia: Elsevier, 2004, 245-249.
  7. Singhal S, Shrager JB, Kaiser LR. Surgical therapy for emphysema In Kaiser LR (ed): Surgical Foundations: Vol. 6, Essentials of Thoracic Surgery. Philadelphia: WB Saunders Co., 2004, 217-229.
  8. Singhal S, Shrager JB, Kaiser LR. Multimodality therapy for non-small cell lung cancer. In Shields TW, LoCicero, Ponn, Rusch (eds). General Thoracic Surgery, Sixth Edition. Philadelphia: Lippincott Williams & Wilkins, 2005, II:XVI(112):1653-1679.
  9. Singhal S, Yang S. Techniques and results in lung transplantation. In Franco KL, Putnam JB (eds): Advanced Therapy in Thoracic Surgery, 2nd Edition. Hamilton, Ontario: B.C. Decker, 2005, 180-195.
  10. Dunham B, Le Visage CL, Singhal S, Flint P, Loeong K. Tracheal tissue engineering. In Bronzino JD (ed): The Biomedical Engineering Handbook, 3rd Edition, Vol. 3: Tissue Engineering & Artificial Organs. Boca Raton, FL: CRC Press, 2006, 151-179.
  11. Singhal S, Kaiser LR. Video-assisted thoracic surgery. In Cameron JL (ed.): Current Surgical Therapy, 9th Edition. Philadelphia: Elsevier Science, 2008, 1358-1366.
  12. Singhal S, Kaiser LR. Surgery for Myasthenia Gravis. In Patterson A, Cooper JD, Deslauriers J, Lerut AEMR, Luketich JD, Rice TW (eds.): Pearson’s Thoracic Surgery, 3rd Edition. Philadelphia: Elsevier Science, 2008.
 
Books
  1. Kaiser LR, Singhal S. Surgical Foundations: Essentials of Thoracic Surgery. Philadelphia: Elsevier Science, 2004.
 

Lectures by Invitation
“Gene Expression Profiling of Malignant Mesothelioma Oncogenesis.” International Mesothelioma Interest Group. 6th Annual Meeting. Perth, Australia. December 2002.

“Functional Genomics in Thoracic Malignancies.” Royal College of Surgeons. Pulmonary Medicine Research Conference. Beaumont Hospital, Dublin, Ireland. October 8, 2003.

“Genetics and Mesothelioma.” European Association for Cardio-Thoracic Surgery. Postgraduate Seminar in Modern Approach to New and Old Problems in Thoracic Surgery. 2nd Annual Meeting EACTS/ESTS. Vienna, Austria. October 12, 2003.

“Gene Expression Mapping to Diagnose Malignant Mesothelioma.” American College of Surgeons. Surgical Forum. 88th Annual Meeting. San Francisco, California. October 2002.

“Genomic Profiling to Explain Positive PET-18FDG Imaging in Patients with Malignant Pleural Mesothelioma.” American Association of Surgery. 36th Annual Meeting. Boston, MA. November 2002.

“Comparison of Stages I-II Thymoma Treated By Complete Resection With or Without Postoperative Irradiation.” 39th Annual Meeting. Society of Thoracic Surgeons. San Diego, CA. January 2003.

“Transcript Profiling of Patients with Node Negative Lung Adenocarcinomas to Predict Survival.” General Thoracic Surgery Forum. 83rd Annual Meeting. American Association for Thoracic Surgery. Boston, MA. May 2003.

“Preoperative Viral Gene Transfer of Interferon-Beta Prevents Recurrence and Improves Survival In Advanced Thoracic Malignancies.” Lillehei Resident Competition. 83rd Annual Meeting. American Association for Thoracic Surgery. Boston, MA. May 2003. (* C. Walton Lillehei Resident Award)

“Viral Gene Transfer of Interleukin-12 Prolongs Survival and Prevents Recurrence in Early and Advanced Non-Small Cell Lung Cancer.” American College of Surgeons. Surgical Forum. 89th Annual Meeting. Chicago, Illinois. October 22, 2003.

“Gene Expression Profiling to Distinguish Head and Neck Squamous Cell Carcinoma Metastases from Primary Lung Squamous Cell Carcinoma.” American College of Surgeons. Surgical Forum. 90th Annual Meeting. New Orleans, Louisana. October 13, 2004.

“Genomics and Lung Cancer: What Every Clinician Needs to Know.” Roswell Park Cancer Institute. Surgical Grand Rounds. Buffalo, New York. October 11, 2006.

“Image Guided Cancer Surgery.” The 2008 Frontiers of Cancer Nanotechnology Symposium. Callaway Gardens, Pine Mountain, Georgia. March 31, 2008.

“Gene Expression Mapping to Diagnose Malignant Mesothelioma.” The Eunice and Irving Annual Scientific Symposium: Advances in Cancer Research. Philadelphia, PA. March 2002.

“Gene Expression Mapping to Diagnose Malignant Mesothelioma.” University of Pennsylvania Department of Medicine Research Retreat. Philadelphia, PA. May 2002.

“Gene Expression Mapping to Diagnose Malignant Mesothelioma.” University of Pennsylvania 8th Annual Respiration Research Retreat. Germantown, PA. June 2002.

“Phase I clinical trials of intrapleural gene therapy for malignant mesothelioma.” 40th Annual Meeting, The Pennsylvania Association for Thoracic Surgery. Miama, Florida. October 2002

“Transcript Profiling of Malignant Mesothelioma Using cDNA microarrays.” 40th Annual Meeting, The Pennsylvania Association for Thoracic Surgery. Miama, Florida. October 2002.

“Transcript Profiling of Patients with Node Negative Lung Adenocarcinoma Predict Patient Outcome.” The Eunice and Irving Annual Scientific Symposium: Advances in Cancer Research. Philadelphia, PA. April 2003.

“Transcript Profiling of Patients with Node Negative Lung Adenocarcinoma Predict Patient Outcome.” University of Pennsylvania Department of Medicine Research Retreat. Philadelphia, PA. May 2003.

“Preoperative Viral Gene Transfer of Interferon-Beta In Advanced Thoracic Malignancies.” Annual Meeting. Baltimore Academy of Surgery. Baltimore, MD. February 2004. (Resident Research Award)

“Adjuvant Chemotherapy for Resectable Non-small Cell Lung Cancer.” Sinai Hospital Oncology Conference. Baltimore, MD. October 2004.

“Genomics in Thoracic Malignancies.” The Johns Hopkins Hospital Department of Surgery Research Conference. Baltimore, MD. December 2004.

“Open Thoracotomy for Stage I Non-Small Cell Lung Cancer.” Johns Hopkins Hospital Department of Surgery Grand Rounds. Baltimore, MD. April 2005.

“Preoperative Viral Gene Transfer of Interferon-Beta Prevents Recurrence and Improves Survival In Advanced Thoracic Malignancies.” Johns Hopkins Department of Surgery Grand Rounds. Baltimore, MD. June 2005.

“Surgical Approaches to Pericardial Window.” University of Pennsylvania Multidisciplinary Cardiovascular Conference. Philadelphia, PA. October 2006.

“Cardiothoracic Transplantation: Changing Face of Perioperative Immunosuppression.” University of Pennsylvania Multidisciplinary Cardiovascular Conference. Philadelphia, PA. December 2006.

“Postoperative Care of the Routine General Thoracic Surgery Patient.” Emory University/Atlanta VAMC ICU Conference. Decatur, GA. October 2007.

“Esophageal dysphagia.” Invited Speaker. Regional Course on Contemporary Techniques in Gastrointestinal Surgery. Atlanta, Georgia. May 2008.

 


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