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Sunil
Singhal, M.D. Thoracic Surgery
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| Research Publications,
Peer Reviewed |
- Singhal S,
Ratner LE. Unilateral renal agenesis with pelvic renal ectopy.
Journal of the American College of Surgeons 193(3):330,
Sept. 2001.
- Singhal S,
Amin KM, Kruklitis R, DeLong P, Friscia ME, Litzky LA, Putt
ME, Kaiser LR, Albelda SM. Alterations in cell cycle genes
in early stage lung adenocarcinoma identified by expression
profiling. Cancer Biology & Therapy 2(3):291-298, May/June
2003.
- Perkowski S, Sun J, Singhal
S, Santiago J, Leikauf GD, Albelda SM. Gene expression
profiling of the early pulmonary response to hyperoxia in
mice. American Journal of Respiratory Cell & Molecular
Biology 28(6):682-696, June 2003.
- Singhal S,
Kyvernitis CG, Johnson SW, Kaiser LR, Liebman MN, Albelda
SM. Micro-array data simulator for improved selection of
differentially expressed genes. Cancer Biology & Therapy
2(4):383-391, July/Aug. 2003.
- Singhal S,
Wiewrodt R, Malden LD, Amin KM, Matzie K, Friedberg J, Kucharczuk
JC, Litzky LA, Johnson SW, Kaiser LR, Albelda SM. Gene expression
profiling of malignant mesothelioma. Clinical Cancer Research
9(8):3080-3097, Aug. 1, 2003.
- Singhal S,
Amin KM, Kruklitis R, Marshall MB, Kucharczuk JC, DeLong
P, Litzky LA, Kaiser LR, Albelda SM. Differentially expressed
apoptotic genes in early stage lung adenocarcinoma predicted
by expression profiling. Cancer Biology & Therapy 2(5):566-571,
Sept./Oct. 2003.
- Singhal S,
Shrager JB, Rosenthal DI, LiVolsi VA, Kaiser LR. Comparison
of stages I-II thymoma treated by complete resection with
or without adjuvant radiation. Annals of Thoracic Surgery
76(5):1635-1642, Nov. 2003.
- Cook JW, Sterman DH,
Singhal S, Smythe WR, Kaiser LR. Suramin
inhibits the growth of malignant mesothelioma in vitro,
and in vivo, in murine flank and intraperitoneal models.
Lung Cancer 42(3):263-274, Dec. 2003.
- Paulson EC, Singhal
S, Kucharczuk JC, Sterman DH, Kaiser LR, Marshall
MB. Bronchial sleeve resection for posttransplant stricture.
Annals of Thoracic Surgery 76(6):2075-2076, Dec. 2003.
- Kruklitis RJ, Singhal
S, Delong P, Kapoor V, Sterman DH, Kaiser LR, Albelda
SM. Immuno-gene therapy with interferon-beta before surgical
debulking delays recurrence and improves survival in a murine
model of malignant mesothelioma. Journal of Thoracic &
Cardiovascular Surgery 127(1):123-130, Jan. 2004.
- O'Donnell RK, Kupferman
M, Wei SJ, Singhal S, Weber R, O'Malley
B, Cheng Y, Putt M, Feldman M, Ziober B, Muschel RJ. Gene
expression signature predicts lymphatic metastasis in squamous
cell carcinoma of the oral cavity. Oncogene 24(7):1244-1251,
Feb. 10, 2005.
- Wade KC, Guttentag SH,
Gonzales LW, Maschhoff KL, Gonzales J, Kolla V, Singhal
S, Ballard PL. Gene induction during differentiation
of human pulmonary type II cells in vitro. American Journal
of Respiratory Cell & Molecular Biology 34(6):727-737,
June 2006.
- Nathan H, Singhal
S, Cameron JL. Benign pneumatosis intestinalis
in the setting of celiac disease. Journal of Gastrointestinal
Surgery 10(6):890-894, June 2006.
- Singhal S,
Cooper JM, Cheung AT, Acker MA. Images in cardiovascular
medicine: Rib perforation from a right ventricular pacemaker
lead. Circulation 115(14):e391-392, Apr. 10, 2007.
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| Research Publications, Peer Reviewed |
- Vachani A, Nebozhyn M,
Singhal S, Alila L, Wakeam E, Muschel R,
Powell CA, Gaffney P, Singh B, Brose MS, Litzky LA, Kucharczuk
J, Kaiser LR, Marron JS, Showe MK, Albelda SM, Showe LC.
A 10-gene classifier for distinguishing head and neck squamous
cell carcinoma and lung squamous cell carcinoma. Clinical
Cancer Research 13(10):2905-2915, May 15, 2007.
- Fabre D, Fadel E, Singhal
S, de Montpreville V, Mussot S, Mercier O, Chataigner
O, Dartevelle PG. Complete resection of pulmonary inflammatory
pseudotumors has excellent long-term prognosis. Journal
of Thoracic & Cardiovascular Surgery 137(2):435-440,
Feb. 2009.
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| Reviews in Peer Reviewed Research
Publications |
- Singhal S,
Kaiser LR. Cancer chemotherapy using suicide genes. [Review]
Surgical Oncology Clinics of North America 7(3):505-536,
July 1998.
- Singhal S,
Johnson CA, Udelsman R. Primary hyperparathyroidism: What
every orthopedic surgeon should know. [Review] Orthopedics
24(10):1003-1011, Oct. 2001.
- Singhal S,
Kaiser LR. Malignant mesothelioma: options for management.
[Review] Surgical Clinics of North America 82(4):797-831,
Aug. 2002.
- Greenberg J, Singhal
S, Kaiser LR. Giant bullous disease: Evaluation,
selection, techniques & outcomes. [Review] Chest Surgery
Clinics of North America 13(4):631-650, Nov. 2003.
- Lee LS, Singhal
S, Brinster CJ, Marshall B, Kochman ML, Kaiser
LR, Kucharczuk JC. Current management of esophageal leiomyoma.
[Review] Journal of the American College of Surgeons 198(1):136-146,
Jan. 2004.
- Brinster CJ, Singhal
S, Lee L, Marshall MB, Kaiser LR, Kucharczuk JC.
Evolving options in the management of esophageal perforation.
[Review] Annals of Thoracic Surgery 77(4):1475-1483, Apr.
2004.
- Singhal S,
Vachani A, Antin-Ozerkis D, Kaiser LR, Albelda SM. Prognostic
implications of cell cycle, apoptosis, and angiogenesis
biomarkers in non-small cell lung cancer: a review. [Review]
Clinical Cancer Research 11(11):3974-3986, June 1, 2005.
- Singhal S,
Miller D, Ramalingam S, Sun SY. Gene expression profiling
of non-small cell lung cancer. [Review] Lung Cancer 60(3):313-324,
June 2008.
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| Editorials, Chapters & Participation
in Committee Reports |
- Singhal S,
Machtay M, Kaiser LR. Malignant mesothelioma. Chap. 19 in
Torosian M. (ed): Integrated Cancer Management. New York:
Marcel Dekker Publ., 1999, 477-523.
- Singhal S,
Kaiser LR. Multimodality therapy for non-small cell lung
cancer. In Shields TW, LoCicero J, Ponn RB (eds): General
Thoracic Surgery 5th Edition. Philadelphia: Lippincott Williams
& Wilkins, 2000, I:XV(106):1415-1442.
- Singhal S,
Kaiser LR. Benign and malignant mesothelioma. Chap. 22 in
Bland KI, Daly JM, Karakousis CP (eds): Surgical Oncology:
Contemporary Principles & Practice. New York: 2001,
1069-1102.
- Singhal S,
Shrager JB, Kaiser LR. Biological treatments for lung cancer.
In Sculier JP, Fry WA (eds): Clinique des Soins Intensifs
Oncologiques et de Cancerologie Pulmonaire. Bruxelles, France:
Researu Iris, 11(1):56-59, 2003.
- Singhal S.
Thoracic surgery. Chap. 19 in Makary MA (ed): General Surgery
Review. Washington: Ladner-Drysdale, 2004, 197-214.
- Singhal S,
Yang S. Lung volume reduction surgery: Median sternotomy
approach. Sect. 11, Chap. 75 in Yang S, Cameron D (eds):
Current Therapy in Thoracic and Cardiovascular Surgery.
Philadelphia: Elsevier, 2004, 245-249.
- Singhal S,
Shrager JB, Kaiser LR. Surgical therapy for emphysema In
Kaiser LR (ed): Surgical Foundations: Vol. 6, Essentials
of Thoracic Surgery. Philadelphia: WB Saunders Co., 2004,
217-229.
- Singhal S,
Shrager JB, Kaiser LR. Multimodality therapy for non-small
cell lung cancer. In Shields TW, LoCicero, Ponn, Rusch (eds).
General Thoracic Surgery, Sixth Edition. Philadelphia: Lippincott
Williams & Wilkins, 2005, II:XVI(112):1653-1679.
- Singhal S,
Yang S. Techniques and results in lung transplantation.
In Franco KL, Putnam JB (eds): Advanced Therapy in Thoracic
Surgery, 2nd Edition. Hamilton, Ontario: B.C. Decker, 2005,
180-195.
- Dunham B, Le Visage CL,
Singhal S, Flint P, Loeong K. Tracheal
tissue engineering. In Bronzino JD (ed): The Biomedical
Engineering Handbook, 3rd Edition, Vol. 3: Tissue Engineering
& Artificial Organs. Boca Raton, FL: CRC Press, 2006,
151-179.
- Singhal S,
Kaiser LR. Video-assisted thoracic surgery. In Cameron JL
(ed.): Current Surgical Therapy, 9th Edition. Philadelphia:
Elsevier Science, 2008, 1358-1366.
- Singhal S,
Kaiser LR. Surgery for Myasthenia Gravis. In Patterson A,
Cooper JD, Deslauriers J, Lerut AEMR, Luketich JD, Rice
TW (eds.): Pearson’s Thoracic Surgery, 3rd Edition.
Philadelphia: Elsevier Science, 2008.
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| Books |
- Kaiser LR, Singhal
S. Surgical Foundations: Essentials of Thoracic
Surgery. Philadelphia: Elsevier Science, 2004.
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Lectures by Invitation
“Gene Expression Profiling
of Malignant Mesothelioma Oncogenesis.” International
Mesothelioma Interest Group. 6th Annual Meeting. Perth, Australia.
December 2002.
“Functional Genomics
in Thoracic Malignancies.” Royal College of Surgeons.
Pulmonary Medicine Research Conference. Beaumont Hospital,
Dublin, Ireland. October 8, 2003.
“Genetics and Mesothelioma.”
European Association for Cardio-Thoracic Surgery. Postgraduate
Seminar in Modern Approach to New and Old Problems in Thoracic
Surgery. 2nd Annual Meeting EACTS/ESTS. Vienna, Austria. October
12, 2003.
“Gene Expression
Mapping to Diagnose Malignant Mesothelioma.” American
College of Surgeons. Surgical Forum. 88th Annual Meeting.
San Francisco, California. October 2002.
“Genomic Profiling
to Explain Positive PET-18FDG Imaging in Patients with Malignant
Pleural Mesothelioma.” American Association of Surgery.
36th Annual Meeting. Boston, MA. November 2002.
“Comparison of Stages
I-II Thymoma Treated By Complete Resection With or Without
Postoperative Irradiation.” 39th Annual Meeting. Society
of Thoracic Surgeons. San Diego, CA. January 2003.
“Transcript Profiling
of Patients with Node Negative Lung Adenocarcinomas to Predict
Survival.” General Thoracic Surgery Forum. 83rd Annual
Meeting. American Association for Thoracic Surgery. Boston,
MA. May 2003.
“Preoperative Viral
Gene Transfer of Interferon-Beta Prevents Recurrence and Improves
Survival In Advanced Thoracic Malignancies.” Lillehei
Resident Competition. 83rd Annual Meeting. American Association
for Thoracic Surgery. Boston, MA. May 2003. (* C. Walton Lillehei
Resident Award)
“Viral Gene Transfer
of Interleukin-12 Prolongs Survival and Prevents Recurrence
in Early and Advanced Non-Small Cell Lung Cancer.” American
College of Surgeons. Surgical Forum. 89th Annual Meeting.
Chicago, Illinois. October 22, 2003.
“Gene Expression
Profiling to Distinguish Head and Neck Squamous Cell Carcinoma
Metastases from Primary Lung Squamous Cell Carcinoma.”
American College of Surgeons. Surgical Forum. 90th Annual
Meeting. New Orleans, Louisana. October 13, 2004.
“Genomics and Lung
Cancer: What Every Clinician Needs to Know.” Roswell
Park Cancer Institute. Surgical Grand Rounds. Buffalo, New
York. October 11, 2006.
“Image Guided Cancer
Surgery.” The 2008 Frontiers of Cancer Nanotechnology
Symposium. Callaway Gardens, Pine Mountain, Georgia. March
31, 2008.
“Gene Expression
Mapping to Diagnose Malignant Mesothelioma.” The Eunice
and Irving Annual Scientific Symposium: Advances in Cancer
Research. Philadelphia, PA. March 2002.
“Gene Expression
Mapping to Diagnose Malignant Mesothelioma.” University
of Pennsylvania Department of Medicine Research Retreat. Philadelphia,
PA. May 2002.
“Gene Expression
Mapping to Diagnose Malignant Mesothelioma.” University
of Pennsylvania 8th Annual Respiration Research Retreat. Germantown,
PA. June 2002.
“Phase I clinical
trials of intrapleural gene therapy for malignant mesothelioma.”
40th Annual Meeting, The Pennsylvania Association for Thoracic
Surgery. Miama, Florida. October 2002
“Transcript Profiling
of Malignant Mesothelioma Using cDNA microarrays.” 40th
Annual Meeting, The Pennsylvania Association for Thoracic
Surgery. Miama, Florida. October 2002.
“Transcript Profiling
of Patients with Node Negative Lung Adenocarcinoma Predict
Patient Outcome.” The Eunice and Irving Annual Scientific
Symposium: Advances in Cancer Research. Philadelphia, PA.
April 2003.
“Transcript Profiling
of Patients with Node Negative Lung Adenocarcinoma Predict
Patient Outcome.” University of Pennsylvania Department
of Medicine Research Retreat. Philadelphia, PA. May 2003.
“Preoperative Viral
Gene Transfer of Interferon-Beta In Advanced Thoracic Malignancies.”
Annual Meeting. Baltimore Academy of Surgery. Baltimore, MD.
February 2004. (Resident Research Award)
“Adjuvant Chemotherapy
for Resectable Non-small Cell Lung Cancer.” Sinai Hospital
Oncology Conference. Baltimore, MD. October 2004.
“Genomics in Thoracic
Malignancies.” The Johns Hopkins Hospital Department
of Surgery Research Conference. Baltimore, MD. December 2004.
“Open Thoracotomy
for Stage I Non-Small Cell Lung Cancer.” Johns Hopkins
Hospital Department of Surgery Grand Rounds. Baltimore, MD.
April 2005.
“Preoperative Viral
Gene Transfer of Interferon-Beta Prevents Recurrence and Improves
Survival In Advanced Thoracic Malignancies.” Johns Hopkins
Department of Surgery Grand Rounds. Baltimore, MD. June 2005.
“Surgical Approaches
to Pericardial Window.” University of Pennsylvania Multidisciplinary
Cardiovascular Conference. Philadelphia, PA. October 2006.
“Cardiothoracic Transplantation:
Changing Face of Perioperative Immunosuppression.” University
of Pennsylvania Multidisciplinary Cardiovascular Conference.
Philadelphia, PA. December 2006.
“Postoperative Care
of the Routine General Thoracic Surgery Patient.” Emory
University/Atlanta VAMC ICU Conference. Decatur, GA. October
2007.
“Esophageal dysphagia.”
Invited Speaker. Regional Course on Contemporary Techniques
in Gastrointestinal Surgery. Atlanta, Georgia. May 2008. |
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