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Transplant Surgical Research
Ali Naji, M.D., Ph.D. |
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The basic and translational research activity in Dr.
Naji's laboratory is directed in three fronts:
- The immunobiology of rejection
and tolerance to tissue and organ allografts. Specific
emphasis is placed on the induction of immune tolerance
to pancreatic islet transplants as the most specific
therapy for diabetes mellitus.
- The cellular and molecular
basis of immune pathogenesis of insulin-dependent
diabetes mellitus. Specifically, the role of B-lymphocytes
as antigen presenting cells for the activation of
islet reactive T lymphocytes is pursued.
- Clinical trials of isolated
pancreatic islet transplantation in patients with
Type I (insulin-dependent) diabetes mellitus.
Research
Publications |
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