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Dr.
Noorchashm’s laboratory is focused on delineating
the cellular basis of autoimmunity and organ transplant
rejection. The overall goal is to identify novel targets
of immune modulation for the induction of tolerance
in the context of autoimmunity and transplantation.
Currently the lab is focused on examining the relationship
between T cell compartment homeostasis and the maintenance
of tolerance to self- and transplanted tissues. With
respect to autimmune diabetes, the inbred non-obese
diabetic (NOD) mouse strain serves as an important paradigm
of dysregulated T cell tolerance to tissue specific
autoantigens. These mice spontaneously develop diabetes
due to a T cell mediated destruction of pancreatic islet
b cells,
which are responsible for the production of insulin.
Using this model of organ specific autoimmunity, the
lab is focused on identification of dysregulated points
in: 1) thymic T cell development and selection and 2)
peripheral T cell activation and homeostasis, which
lead to the development of organ-specific autoimmunity.
Recent
Publications:
Siri
A. Greeley, Katsumata M., Yu L., Eisenbarth G.S., Moore
D.J., Goodarzi H., Barker C.F., Naji A., Noorchashm
H. Elimination
of Maternally-Transmitted Autoantibodies Prevents Diabetes
in Non-Obese Diabetic Mice. Nature Medicine, 8(4):399-402.
Hooman
Noorchashm,
Moore D., Noto L.E., Noorchashm N., Reed A.J., Reed
A.L., Mozaffari R., Song H.K., Jevnikar A.M., Barker
C.F., Naji A. 2000.
Impaired CD4 T Cell Activation Due to Reliance Upon
B Cell Mediated Costimulation in Non-Obese Diabetic
(NOD) Mice. Journal of Immunology, 165:4685-4696.
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