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| Research Grants |
NIH/NIDDK U01-DK-062494 (Olthoff,
PI) Adult to Adult Living Donor Liver Transplant Cohort
Study (A2ALL)
Penn is one of 9 centers in this multi-center trial with the primary
goal of providing information on the outcomes of adult to adult living
donor liver transplantation in donors and recipients.
NIH/NIDDK RO1-DK073192 (Olthoff, PI)
Regeneration in the Transplant Setting: An Ancillary Study
to the A2ALL
This study is within the cooperative, multi-site A2ALL consortium,
examining the mechanisms occurring in the early post-transplantation
period that drive molecular networks for liver regeneration and
tissue repair required for graft and patient survival in living
donor and deceased donor liver transplantation.
NIH/NIAID U01 A1063589 (Shaked, PI, Olthoff, Center Co-I)
Clinical trials in organ transplantation (CTOT-3) –
Correlation of donor proinflammatory mRNA profiles with early outcomes
of thoracic and abdominal transplantation
This study is a prospective observational cohort designed to test
the association of proinflammatory pathways of injury in lung, heart,
liver and kidney allografts with immediate and short-term function
as well subsequent alloimmune response. This study will profile
gene expression for the characterization of innate immunity and
adaptive immunity pertinent to solid organ transplantation. Dr.
Olthoff directs the liver studies
NIH/NIAID U01 AI052748 (Olthoff, Site PI)
Solid Organ Transplantation in HIV: Multi-Site Study
The University of Pennsylvania is one of 16 transplant centers from
across the country participating in this multi-site study investigating
outcomes in kidney and liver transplantation in people with HIV.
Biesecker Center for Liver Disease – Private Grant
Models of liver regeneration and ischemia/reperfusion injury
in the transplant setting
This privately funded research grant provides support for the murine
studies investigating the roles of growth factors and metabolic
pathways in liver regeneration. |
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| Publications
(selected from 100 peer reviewed publications) |
- Olthoff KM,
Rosove MH, Imagawa DK, Shackleton CR, Farmer D, Martin P, Goldstein
LI, Shaked A, Busuttil RW. Adjuvant chemotherapy improves survival
following liver transplantation for hepatocellular carcinoma.
Ann Surg 1995 221:734-743.
- Olthoff KM,
Judge TA, Gelman A, Chen X, Hancock WW, Turka LA, Shaked A. Adenovirus-mediated
gene transfer into cold-preserved liver allografts: Survival pattern
and unresponsiveness following transduction with CTLA4Ig. Nat
Med 1998 4:194-200.
- Olthoff KM,
Shaked A, Yi J, Gelman AE, Shen X, Kesmodel S, Poma SH, Krasinkas
AM, Rosengard BR, Kovalovich K, DeAngelis RA, Taub R. Intrahepatic
bone marrow derived cells are responsible for IL-6-induced STAT
3 activation after partial hepatectomy. Hepatology 1998 28:402A.
- Olthoff KM,
Shen XD, Debonera F, Gao F, Aldeguer X, Gelman AE, Hiroyashu S,
Furth EE, Shaked A, Taub R. Initiation of early signal transduction
pathways in the liver following cold ischemia and reperfusion
injury. Transplantation 1999 67(9):S559.
- Lehrer MS, Ruchelli E, Olthoff
KM, French LE, Rook AH. Successful reversal of recalcitrant
hepatic allograft rejection by photopheresis. Liver Transpl 2000
6:644-647.
- Zamir GA, Markmann JF, Abrams
J, Macatee MR, Nunes FA, Shaked A, Olthoff KM.
The fate of liver grafts declined for subjective reasons and transplanted
out of a local procurement organization. Transplantation 2000
70(8):1149-1154.
- Debonera F, Aldeguer X, Shen
X, Gelman AE, Gao F, Que X, Greenbaum LE, Furth EE, Taub R, Olthoff
KM. Activation of IL-6/STAT3 and liver regeneration following
transplantation. J Surg Res 2001 96:289-295.
- Zamir G, Gelman A, Debonera
F, Hardwigsen J,Que X, Aldeguer X, Martin M, Shaked A, Olthoff
K. Modified AdCTLA-4 vector blocks alloimmune response
in-vitro. J Surg Res 2001 97:155-158.
- Singer AL, Olthoff
KM, Kim H, Rand E, Zamir G, Shaked A. The role of plasmapheresis
in the management of acute hepatic failure in the pediatric population.
Ann Surg 2001 234: 418-424.
- Olthoff KM,
Gelman AE, Zamir GA, Debonera F, Krasinkas AM, Shen X, Gao F,
Shaked A. Pattern of alloimmune response in second same donor
allografts after induction of tolerance using CTLA4Ig. Transplantation
2001 Dec 27:72(12):1952-6.
- Aldeguer X, Debonera F, Shaked
A, Krasinkas AM, Que X, Zamir GA, Hiroyasu S, Kovalovich KK, Taub
R, Olthoff KM. Interleukin-6 from cells of bone
marrow origin is required for normal liver regeneration. Hepatology
2002 Jan:35(1):40-8.
- Debonera F, Krasinkas A, Aldequer
X, Que X, Gelman A, Shaked A, Olthoff K. Dexamethasone
inhibits the early regenerative response of the rat liver after
cold preservation and transplantation. Hepatology 2003 Dec:38(6):1563-1572.
- Que X, Debonera F, Xie J, Furth
EE, Aldeguer X, Gelman AE, Olthoff KM. Pattern
of ischemia reperfusion injury in a mouse orthotopic liver transplant
model J Surg Res 2004116:262-268.
- Shetty K, Timmins K, Brensinger
C, Furth EE, Rattan S, Sun W, Rosen M, Soulen M, Shaked A, Reddy
KR, Olthoff KM. Liver transplantation for hepatocellular
carcinoma: Validation of present selection criteria in predicting
outcome. Liver Transpl 2004 10(7):911-918.
- Abt PL, Mange K, Olthoff
KM, Reddy R, Shaked A. Allograft survival following adult
to adult living donor liver transplantation. Am J Transplant 2004;4(8):1302-7.
- Abt PL, Rapaport-Kelz R, Desai
N, Frank A, Sonnad S, Rand E, Markmann JF, Shaked A, Olthoff
KM. Survival among pediatric liver transplant recipients:
Impact of segmental grafts. Liver Transpl 2004 10(10):1287.
- Olthoff KM,
Brown RS Jr., Delmonico FL, Freeman RB, McDiarmid SV, Merion RM,
Millis JM, Roberts JP, Shaked A, Wiesner RH, Lucey MR. Summary
report of a national conference: Evolving concepts in liver allocation,
the MELD and PELD era. Liver Transpl. 2004 10 Suppl 10:A6.
- Makuuchi M, Miller CM, Olthoff
K, Schwartz M. Adult-adult living donor liver transplantation.
J Gastrointest Surg 2004 8(3):303-12.
- Hanto DW, Fishbein TM, Pinson
CW, Olthoff KM, Shiffman ML, Punch JD, Goodrich
NP. Liver and intestine transplantation: Summary Analysis, 1994-2003.
Am J. Transplant 2005 5(Part 2)916-933.
- Debonera F, Wang G, Xie J,
Gelman A, LeClair C, Xin D, Shaked A, Olthoff KM.
Severe preservation injury induces II-6/STAT3 activation with
lack of cell cycle progression after partial liver graft transplantation.
Am J Transplant 2004 Dec:4(12):1964-71.
- Olthoff KM,
Merion RM, Ghobrial RM, Abecassis MM, Fair JH, Fisher RA, Freise
CE, Kam I, Pruett TL, Everhart JE, Hulbert-Shearon TE, Gillespie,
BW, Edmond JC, A2ALL Study Group. Outcomes of 385 Adult-to-Adult
Living Donor Liver Transplant Recipients. Ann Surg 2005 242(3):1-12.
- Elstrom RL, Andreadis C, Aqui
NA, Ahya VN, Bloom RD, Brozena SC, Olthoff KM,
Schuster SJ, Nasta SD, Stadtmauer EA, Tsai DE. Treatment of PTLD
with rituximab or chemotherapy. Am J Transplant 2006 Mar;6(3):569-76.
- Xie JF, Wang G, Debonera F,
Han R, Dorf ME, Hancock W, Olthoff KM. Selective
neutralization of the chemokine TCA3 reduces the increased injury
of partial versus whole liver transplants induced by cold preservation.
Transplantation 2006 Dec 15;82(11):1501-9.
- Fisher RA, Kulik LM, Freise
CE, Lok ASF, Shearon TH, Brown Jr. RS, Ghobrial RM, Fair JH, Olthoff
KM, Kam I, Berg CL, A2ALL Study Group. Hepatocellular
carcinoma recurrence and death following living and deceased donor
liver transplantation: The A2All Study. Am J Transplant 2007 Jun;7(6):1601-8.
- Ghobrial RM, Freise CE, Trotter
JF, Tong L, Ojo AO, Fair JH, Fisher RA, Kinkhabwala MM, Koffron
AJ, Pruett TL,Olthoff KM, A2ALL Study Group.
Donor morbidity and mortality of adult-to-adult living donor liver
transplantation. (Submitted for publication Am J Transplant 2007).
- Roland ME, Barin B, Carlson
L, Frassetto LA, Terrault NA, Hirose R, Freise CE, Benet LZ, Ascher
NL, Roberts JP, Murphy B, Keller MJ, Olthoff KM,
Blumberg EA, Brayman KL, Bartlett ST, Davis CE, McCune JM, Bredt
BM, Stablein DM, Stock PG. HIV-Infected liver and kidney transplant
recipients: 1- and 3- year outcomes. Am J
Transplant 2008 8:355-365.
- Nakamoto N, Kaplan DE, Coleclough
J, Li Y, Kaminski M, Shaked A, Olthoff KM, Gostick
E, Price DA, Freeman GJ, Wherry EJ, Chang K-M. Functional restoration
of HCV-specific CD8 T-cells by PD1 blockage is defined by PD1
expression and compartmentalization. Gastroenterology 2008 134(7):1927-37.
- Bahirwani R, Campbell M, Siropaides
T, Markmann J, Olthoff KM, Shaked A, Bloom R,
Reddy R. Transplantation: Impact of pre-transplant renal insufficiency.
Liver Transpl 2008 14:665-71.
- Read A, Merion RM, Roberts JP,
Klintmalm GB, Abecassis MM, Olthoff KM, Langnas
AN. The declaration of Istanbul: review and commentary by the
American Society of Transplant Surgeons Ethics Committee and Executive
Committee. Am J Transplant 2009 Nov;9(11):2466-9.
- Shiley KT, Gasink LB, Barton
TD, Pfeiffenberger P, Olthoff KM, Blumberg EA.
Increased incidence of cytomegalovirus infection in high-risk
liver transplant recipients receiving valganciclovir prophylaxis
versus ganciclovir prophylaxis. Liver Transpl 2009 Aug;15(8):963-8.
- Marin HL, Furth EE, Olthoff
K, Shaked A, Soulen MC. Histopathologic outcome of neoadjuvant
image-guided therapy of hepatocellular carcinoma. J Gastrointestin
Liver Dis 2009 June;18(2):169-76.
- Abecassis MM, Burke R, Klintmalm
GB, Matas J, Merion RM, Millman D, Olthoff K,
Roberts JP; American Society of Transplant Surgeons. American
society of transplant surgeons transplant center outcomes requirements—a
threat to innovation. Am J Transplant 2009 Jun;9(6):1279-86.
- deJonge J, Kurian S, Shaked
A, Reddy KR, Hancock W, Salomon DR, Olthoff KM.
Unique early gene expression patterns in human adult-to-adult
living donor liver grafts compared to deceased donor grafts. Am
J Transplant 2009 Apr;9(4):758-72.
- Nakamoto N, Cho H, Shaked A,
Olthoff KM, Valiga ME, Kaminski M, Gostick E,
Price DA, Freeman GJ, Wherry EJ, Chang KM. Synergistic reversal
of intrahepatic HCV-specific CD8 T cell exhaustion by combined
PD-1/CTLA-4 blockage. PLoS Pathog 2009 Feb;5(2):e1000313.
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Hoffman SA, Wang L, Shah CV, Ahya VN, Pochettion A, Olthoff
K, Shaked A, Wille K, Lama VN, Milstone A, Ware LB, Orens
J, Weinacker A, Demissie E, Bellamy S, Kawut SM, Hancock WW, Christie
JD, Lung Transplant Outcomes Group. Plasma cytokines and chemokines
in primary graft dysfunction post-lung transplantation. Am J Transplant
2009:Feb;9(2):359-96.
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| Recent Invited Papers/Editorials: |
- Olthoff KM.
Hepatic regeneration in living donor liver transplantation. Liver
Transplantation 2003:9(10):S35-S41.
- Olthoff KM,
Reddy KR. First, Do No Harm: The question of liver biopsy in living
liver donors. Liver Transplantation 2008;14:420-422.
- Olthoff KM.
Small size and disease severity in living donation: a difficult
match. Liver Transplant 2009 May;15(5):457-9.
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