Najjia N. Mahmoud, M.D.
| Current Research |
| Colorectal Cancer
Surgery Outcomes: Colorectal cancer is the third leading
cause of cancer mortality in the US. Surgery is currently
the only known treatment resulting in cure of this disease.
Examination of outcomes of surgery for colorectal cancer
is the focus of current research efforts. |
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| Rectal Cancer Database
(institutional—University of Pennsylvania) |
- Efforts center on defining
optimal neoadjuvant treatment in advanced stage rectal
cancer with increased sphincter preservation and morbidity
the primary endpoints.
- Use of this prospectively
maintained database to define factors influencing
medical and surgical outcomes in rectal cancers by
age, race, and gender based on treatment and tumor
stage.
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| SEER-Medicare
Database. Use of a national database linked to Medicare
files to better understand and identify trends in the
outcomes of the medical and surgical care and treatment
of colorectal cancer patients. |
- Define differences in care
based upon treatment location/institutional variations.
- Examine how differences in
presentation of colorectal cancer impacts upon disease-free
and overall survival.
- Investigate ways in which
trends in treatment of colorectal cancer diffuse through
the US.
- Explore how widely adopted
“quality measures” such as lymph node
harvest influence and change the surgical treatment
of colon and rectal cancer.
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| Clinical
Trials: The Division of Colon and Rectal Surgery
is committed to ongoing efforts to improve perioperative
care and long-term outcomes in the surgical treatment
of colorectal disease through clinical trials. |
- 2004 Investigator Adolor Protocol
14CL314: A Multicenter, Phase III, Double-Blind, Placebo-Controlled
Parallel Study of ADL 8-2698 in Opioid Induced Postoperative
Bowel Dysfunction/Postoperative Ileus (closed).
- 2004 Co-Investigator: Recurrence
Rate and Sexual Function following Rectocele Repair
using Pelvicol Medical Device (closed).
- 2006 Co-Investigator: American
College of Surgeons Clinical Oncology Group (ACOSOG)
Z6041—A Phase II Trial of Neoadjuvant Chemoradiation
and Local Excision for uT2N0 Rectal Cancer (ongoing).
- 2007 Investigator: Adolor
14CL401 Observational Trial: A Prospective, Observational,
Multicenter Study Assessing Early Postoperative Recovery
Following Laparoscopic Partial Large Bowel Resection
(ongoing).
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| Research
Publications |
