| Pancreatic
inflammation and regeneration:
A major area of interest has been the study of mechanisms
involved in pancreatic inflammation and regeneration.
- To study the interaction
of recombinant viral vectors (adenovirus, adeno-associated
virus, lentivirus) with the pancreas of immunocompetent/immunodeficient
mice;
- To test innovative approaches
to prolong viral transgene expression in transduced
pancreata of immunocompetent mice;
- To study the effect of physiologic
perturbations (streptozotocin, acute pancreatitis,
pancreatic resection) on stability of pancreas directed
gene transfer.
- To study the effects of various
novel inducible transgenes on islet function and number.
The information learned from these
studies is important in understanding the biology of
pancreatic regeneration and islet morphogenesis. The
work will also allow a deeper understanding of pancreatic
immunology and the development of innovative strategies
for pancreas and islet-directed gene therapy.
Research
Publications |
