Penn Surgery

Thoracic Surgery Research Laboratory


  1. Singhal S, Wiewrodt R, Friscia M, Matzie K, Friedberg J, Amin KA, Kucharczuk JC, Albelda SM, Kaiser LR. “Genomic Profiling to Explain Positive PET-18FDG Imaging in Patients with Malignant Pleural Mesothelioma.” J Surg Res. 2002;107:284.
  2. Singhal S, Amin K, Kruklitis R, DeLong P, Friscia ME, Putt ME, Kaiser LR, Albelda SM. “Alterations in Cell Cycle Genes in Early Stage Lung Adenocarcinoma Identified by Expression Profiling.” Cancer Biol Ther. 2003 May-June;2(3):291-8. PMID: 12878869.
  3. Perkowski S, Sun J, Singhal S, Santiago J, Leikauf G, Albelda SM. “Gene Expression Profiling of the Early Pulmonary Response to Hyperoxia in Mice.” Am J Respir Cell Mol Biol. 2003 Jun;28(6):682-696. PMID: 12760966
  4. Singhal S, Kyvernitis CG, Johnson SW, Kaiser LR, Liebman MN, Albelda SM. “Microarray Data Simulator to Evaluate Bioinformatic Tools for Selecting Differentially Expressed Genes in Normal versus Cancerous Tissues.” Cancer Biol Ther. 2003 Jul-Aug;2(4):383-394. PMID: 14508110.
  5. Singhal S, Weiwrodt R, Malden, L, Matzie K, Friedberg J, Amin KM, Kucharczuk JC, Litzky LA, Johnson SW, Kaiser LR, Albelda SM. “Gene Expression Profiling of Malignant Mesothelioma.” Clin Cancer Res. 2003 Aug 1;9(8):3080-3097. PMID 12912960.
  6. Singhal S, Amin K, Kruklitis R, Marshall MB, Kucharczuk JC, DeLong P, Litzky LA, Albelda SM, Kaiser LR. “Differentially Expressed Apoptotic Genes in Node Negative Lung Adenocarcinoma Predicted by Expression Profiling.” Cancer Biol Ther. 2003 Sep-Oct;2(5):566-571. PMID: 14614329.
  7. Singhal S, Shrager JB, Rosenthal DI, LiVolsi VA, Kaiser LR. “Comparison of Stages I-II Thymoma Treated by Complete Resection With or Without Adjuvant Irradiation.” Ann Thorac Surg. 2003 Nov;76(5):1635-41. PMID: 14602300.
  8. Cook, J, Sterman DH, Singhal S, Smythe WR, Kaiser LR. “Suramin Inhibits the Growth of Malignant Mesothelioma in Vitro, And in Vivo, In Murine Flank and Intraperitoneal Models.” Lung Cancer. 2003 Dec;42(3):263-74. PMID: 14644513.
  9. Paulson EC, Singhal S, Kucharczuk JC, Sterman D, Kaiser LR, Marshall MB. “Bronchial Sleeve Resection for Post-Transplant Structure.” Ann Thorac Surg. 2003 Dec;76(6):2075-6. PMID: 14667647.
  10. Kruklitis R, Singhal S, DeLong P, Kapoor V, Sterman D, Kaiser LR, Albelda SM. “Immuno-Gene Therapy with Interferon-Beta Before Surgical Debulking Prevents Recurrence and Improves Survival in Advanced Malignant Mesothelioma.” J Thorac Cardiovasc Surg. 2004 Jan;127(1):123-130. PMID: 14752422.
  11. Lee LS, Singhal S, Brinster CJ, Kaiser LR, Marshall MB, Kochman ML, Kucharczuk JC. “Current Management of Esophageal Leiomyoma.” Journal of J Am Coll Surg. 2004 Jan;198(1):136-46. PMID: 14698321.
  12. Brinster CJ, Singhal S, Lee LS, Marshall MB, Kaiser LR, Kucharczuk JC. “Evolving Options in the Management of Esophageal Perforation.” Ann Thorac Surg. 2004 Apr;77(4):1475-83. PMID: 15063302.
  13. O'Donnell RK, Kupferman M, Wei SJ, Singhal S, Weber R, O'Malley B, Cheng Y, Putt M, Feldman M, Ziober B, Muschel RJ. “Gene Expression Signature Predicts Lymphatic Metastasis in Squamous Cell Carcinoma of the Oral Cavity.” Oncogene. 2005 Feb 10;24(7):1244-51. PMID: 15558013.
  14. Singhal S, Vachani A, Antin-Ozerkis D, Kaiser LR, Albelda SM. “Prognostic Implications of Cell Cycle, Apoptosis, and Angiogenesis Biomarkers in Non–Small Cell Lung Cancer.” Clin Cancer Res. 2005 Jun 1;11(11):3974-3986. PMID: 15930332.
  15. Nathan H, Singhal S, Cameron JL. “Benign Pneumatosis Intestinalis in the Setting of Celiac Disease.” J Gastrointest Surg. 2006 Jun;10(6):890-4. PMID: 16769547.
  16. Wade KC, Guttentag SH, Gonzales LW, Maschhoff KL, Gonzales J, Kolla V, Singhal S, Ballard PL. “Gene Induction During Differentiation of Human Pulmonary Type II Cells in Vitro.” Am J Respir Cell Mol Biol. 2006 Jun;34(6):727-737. PMID: 16474099.
  17. Vachani A, Nebozhyn M, Singhal S, Alila L, Wakeam E, Muschel R, Powell CA, Gaffney P, Singh B, Brose MS, Litzky LA, Kucharczuk J, Kaiser LR, Marron JS, Showe MK, Albelda SM, Showe LC. “A 10-Gene Classifier for Distinguishing Head and Neck Squamous Cell Carcinoma and Lung Squamous Cell Carcinoma.” Clin Cancer Res. 2007 May 15; 13(10):2905-15. PMID: 17504990.
  18. Singhal S, Miller DL, Ramalingam S, Sun SY. “Gene Expression Profiling of Non-Small Cell Lung Cancer.” Lung Cancer. 2008 Jun;60(3):313-324. PMID: 18440087. PMCID: PMC2517078.
  19. Fabre D, Fadel E, Singhal S, Monpreville VD, Mussot D, Mercier O, Chataigner O, Dartevelle PG. “Complete Resection of Pulmonary Inflammatory Pseudotumors has Excellent Long-Term Prognosis.” J Thorac Cardiovasc Surg. 2009 Feb;137(2):435-40. PMID: 19185166.
  20. Fabre, D, Singhal S, De Montpreville V, Decante B, Mussot S, Chataigner O, Mercier O, Kolb F, Dartevelle PG and Fadel E. “Composite Cervical Skin and Cartilage Flap Provides a Novel Large Airway Substitute After Long-Segment Tracheal Resection.” J Thorac Cardiovasc Surg. 2009 Jul;138(1):32-9. PMID: 19577053.
  21. Fridlender ZG, Kapoor V, Buchlis G, Cheng G, Sun J, Wang LS, Singhal S, Snyder LA, Albelda SM. “CCL2 Blockade Augments Cancer Immunotherapy.” Cancer Res. 2010 Jan 1;70(1):109-118. PMID: 20028856. PMCID: PMC2821565.
  22. Singhal S. Ferraris VA, Bridges CR, Clough ER, Mitchell JD, Fernando HC, Shrager JB. “Postoperative Management of Pulmonary Alveolar Air Leaks.” Ann Thorac Surg. 2010 Apr;89(4):1327-35. PMID: 20338378.
  23. Mohs AM, Mancini MC, Singhal S, Provenzale JM, Leyland-Jones B, Wang MD, Nie S. “Handheld Spectroscopic Device for in Vivo and Intraoperative Tumor Detection: Contrast Enhancement, Detection Sensitivity, and Tissue Penetration.” Anal Chem. 2010 Nov 1;82(21):9058-65. Epub 2010 Oct 6. PMID: 20925393. PMCID: PMC3030682.
  24. Fridlender ZG, Sun J, Singhal S, Kapoor V, Cheng G, Albelda SM. “Chemotherapy Delivered After Viral Immunogene Therapy Augments Anti-Tumor Efficacy Via Multiple Immune-Mediated Mechanisms.” Mol Ther. 2010 Nov;18(11):1947-59. Epub 2010 Aug 3. PMID: 20683443. PMCID: PMC2990510.
  25. Singhal S, Shrager JB. “Should Buttresses and Sealants be Used to Manage Pulmonary Parenchymal Air Leaks?” J Thorac Cardiovasc Surg. 2010 Dec;140(6):1220-5. PMID: 20951389.
  26. Singhal S, Nie S, Wang MD. “Nanotechnology Applications in Surgical Oncology.” Annu Rev Med. 2010;61:359-373. PMID: 20059343. PMCID: PMC2913871.
  27. Levine S, Biswas C, Dierov J, Barsotti R, Shrager JB, Nguyen T, Sonnad S, Kucharchzuk JC, Kaiser LR, Singhal S, Budak MT. “Increased Proteolysis and Atrophic AKT-FOXO Signaling in Human Diaphragm Disuse.” American Journal of Respiratory and Critical Care Medicine. 2011 Feb 15;183(4):483-90. Epub 2010 Sep 10. PMID: 20833824. PMCID: PMC3056225.
  28. Fridlender ZG, Kapoor V, Buchlis G, Cheng G, Sun J, Wang LC, Singhal S, Snyder LA and Albelda SM. “Monocyte Chemoattractant Protein-1 Blockade Inhibits Lung Cancer Tumor Growth by Altering Macrophage Phenotype and Activating CD8+ Cells." Am J Respir Cell Mol Biol. 2011 Feb;44(2):230-7. PMID: 20395632. PMCID: PMC3049234.
  29. Aliperti LA, Predina JD, Vachani A, Singhal S. “Local and Systemic Recurrence is the Achilles Heel of Cancer Surgery.” Ann Surg Oncol. 2011 Mar;18(3):603-607. PMID: 21161729.
  30. Ghosh A, Malaisrie N, Leahy KP, Singhal S, Einhorn E, Howlett P, Cohen NA, Mirza N. “Cellular Adaptive Inflammation Mediates Airway Granulation in a Murine Model of Subglottic Stenosis.” Otolaryngol Head Neck Surg. 2011 Jun;144(6):927-33. PMID: 21493347.
  31. Levine S, Budak MT, Dierov J, Singhal S. “Inactivity-Induced Diaphragm Dysfunction and Mitochondrial-Targeted Antioxidants.” Crit Care Med. 2011 Jul;39(7):1844-5. PMID: 21685759.
  32. Berman AT, Litzky L, Livolsi V, Singhal S, Kucharczuk JC, Cooper JD, Friedberg JR, Evans TL, Stevenson J, Metz JM, Hahn SM, Rengan R. “Adjuvant Radiotherapy for Completely Resected Stage II Thymoma.” Cancer. 2011 Aug 1;117(15):3502-8. Epub 2011 Feb 1. PMID: 21287527.
  33. Brunelli, A. Beretta E, Cassivi S., Cerfolio R., Detterbeck F., Kiefer T., Miserocchi G., Shrager J, Singhal S, Raemdonck DV, Varela G. “Consensus Definitions to Promote an Evidence-Based Approach to Management of the Pleural Space. A collaborative proposal by the ESTS, AATS, STS, and GTSC.” Eur J Cardiothorac Surg. 2011 Aug;40(2):291-297. PMID: 21757129.
  34. Su L, Liu G, Hao X, Liu X, Zhong N, Zhong D, Singhal S. “Death Receptor 5 and Cellular FLICE-Inhibitory Protein Regulate Pemetrexed-Induced Apoptosis in Human Lung Cancer Cells.” Eur J Cancer. 2011 Nov;47(16):2471-8. PMID: 21726997.
  35. Predina JD, Judy B, Aliperti LA, Fridlender ZG, Blouin A, Kapoor V, Nakagawa H, Rustgi AK, Aguilar L, Aguilar-Cordova E, Albelda SM, Singhal S. “Neoadjuvant in Situ Gene-Mediated Cytotoxic Immunotherapy Improves Postoperative Outcomes in Novel Syngeneic Esophageal Carcinoma Models.” Cancer Gene Ther. 2011 Dec;18(12):871-83. PMID: 21869822. PMCID: PMC3215998.
  36. Majumdar D, Singhal S. “Medicinal Chemistry and Nanomedicine for Reproductive Cancer Therapeutics.” Front Biosci (Elite Ed). 2012 Jan 1;4:2029-44. PMID: 22202018.
  37. Fridlender ZG, Sun J, Mishalian I, Singhal S, Cheng G, Kapoor V, Horng W, Fridlender G, Bayuh R, Worthen GS, Albelda SM. “Transcriptomic Analysis Comparing Tumor-Associated Neutrophils with Granulocytic Myeloid-Derived Suppressor Cells and Normal Neutrophils.” PLoS ONE. 2012;7(2):e31524. Epub 2012 Feb 14. PMID: 22348096. PMCID: PMC3279406.
  38. Judy BF, Aliperti LA, Predina JD, Levine D, Kapoor V, Thorpe PE, Albelda SM, Singhal S. “Vascular Endothelial-Targeted Therapy Combined with Cytotoxic Chemotherapy Induces Inflammatory Intratumoral Infiltrates and Inhibits Tumor Relapses After Surgery.” Neoplasia. 2012 Apr;14(4):352-9. PMID: 22577350. PMCID: PMC3349261.
  39. O'Shannessy D J, Yu G, Smale R, Fu YS, Singhal S, Thiel RP, Somers EB, and Vachani A. “Folate Receptor Alpha Expression in Lung Cancer: Diagnostic and Prognostic Significance.” Oncotarget. 2012 Apr;3(4):414-25. PMID: 22547449. PMCID: PMC3380576.
  40. Jia G, Su L, Singhal S, Liu X. “Emerging Roles of SIRT6 on Telomere Maintenance, DNA Repair, Metabolism and Mammalian Aging.” Mol Cell Biochem. 2012 May;364(1-2):345-50. PMID: 22286818.
  41. Predina JD, Kapoor V, Judy BF, Cheng G, Fridlender ZG, Albelda SM, Singhal S. “Cytoreduction Surgery Reduces Systemic Myeloid Suppressor Cell Populations and Restores Intratumoral Immunotherapy Effectiveness.” J Hematol Oncol. 2012 Jun 28;5:34. PMID: 22742411. PMCID: PMC3418164.
  42. Liu G, Su L, Hao X, Zhong N, Singhal S, Liu X. “Salermide Upregulates Death Receptor 5 Expression through the ATF4-ATF3-CHOP Axis and Leads to Programmed Cell Death.” J Cell Mol Med. 2012 Jul;16(7):1618-28. PMID: 21801305. PMCID: PMC3823229.
  43. Predina, JD, Judy B, Fridlender ZG, Aliperti LA, Madajewski B, Kapoor V, Cheng G, Quatromoni J, Okusanya O, Singhal S. “A Positive-Margin Resection Model Recreates the Postsurgical Tumor Microenvironment and is a Reliable Model for Adjuvant Therapy Evaluation.” Cancer Biol Ther. 2012 Jul;13(9):745-55. Epub 2012 May 23. PMID: 22617772. PMCID: PMC3606205.
  44. Patnaik SK, Yendamuri S, Kannisto E, Kucharczuk J, Singhal S, Vachani A. “MicroRNA Expression Profiles of Whole Blood in Lung Adenocarcinoma.” PLoS One. 2012;7(9): e46045. Epub 2012 Sep 28. PMID: 23029380. PMCID: PMC3460960.
  45. Madajewski B, Judy B, Mouchli A, Kapoor V, Holt D, Wang MD, Nie S, Singhal S. “Intraoperative Near-Infrared Imaging of Surgical Wounds after Tumor Resections Can Detect Residual Disease.” Clin Cancer Res. 2012 Oct 15;18(20):5741-51. PMID: 22932668. PMCID: PMC3482441.
  46. Tucker ZCG, Laguna BA, Moon E, Singhal S. “Adjuvant Immunotherapy for Non-Small Cell Lung Cancer.” Cancer Treat Rev. 2012 Oct;38(6):650-61. PMID: 22226940.
  47. Laguna BA, Tucker ZCG, DeLisser H, Singhal S. "Letting the Air in Can Set the Stage for Tumor Recurrences.” Current Cancer Therapy Reviews. 2012 Nov;8(4):293-303.
  48. Fabre D, El Batti S, Singhal S, Mercier O, Mussot O, Fadel E, Kolb F, Dartevelle PG. “A Paradigm Shift for Sternal Reconstruction Using a Novel Titanium Rib Bridge System Following Oncological Resections.” Eur J Cardiothorac Surg. 2012 Dec;42(6):965-70. PMID: 22551966.
  49. Predina JD, Judy B, Kapoor V, Blouin A, Aliperti LA, Levine D, Fridlender ZG, Singhal S. “Characterization of Surgical Models of Postoperative Tumor Recurrence for Preclinical Adjuvant Therapy Assessment.” Am J Transl Res. 2012;4(2):206-218. PMID: 22611473. PMCID: PMC3353530.
  50. Predina JD, Eruslanov E, Judy B, Kapoor V, Cheng GJ, Wang S, Sun J, Fridlender G, Albelda SM, Singhal S. “Changes in the Local Tumor Microenvironment in Recurrent Cancers May Explain the Failure of Vaccines after Surgery.” Proc Natl Acad Sci USA. 2013 Jan 29;110(5):E415-24. Epub 2012 Dec 27. PMID: 23271806. PMCID: PMC3562776.
  51. Johnson WR, Fedor D, Singhal S. “A Novel Approach to Eliminate Cardiac Perforation in the Nuss Procedure.” Ann Thorac Surg. 2013 Mar;95(3):1109-11. PMID: 23438552.
  52. Waldron TJ, Quatromoni JG, Karakasheva TA, Singhal S, Rustgi, AK. “Myeloid Derived Suppressor Cells: Targets for Therapy.” Oncoimmunology. 2013 Apr 1;2(4):e24117. PMID: 23734336. PMCID: PMC3654606.
  53. Fridlender Z, Jasaar A, Mishalian I, Wang LC, Kapoor V, Cheng G, Sun J, Singhal S, Levy L, Albelda SM. “Using Macrophage Activation to Augment Immunotherapy of Established Tumors.” Br J Cancer. 2013 Apr 2;108(6):1288-97. Epub 2013 Mar 12. PMID: 23481183. PMCID: PMC3619255.
  54. Okusanya OT, Madajewski B, Segal E, Judy BF, Venegas OG, Judy RP, Quatromoni JG, Wang MD, Nie S, Singhal S. “Small Portable Interchangeable Imager of Fluorescence for Fluorescence Guided Surgery and Research.” Technol Cancer Res Treat. 2015 Apr;14(2):213-20. PMID: 24354756. PMCID: PMC4134767.
  55. Levine S, Bashir M, Clanton T, Powers S, Singhal S. “COPD Elicits Remodeling of the Diaphragm and Vastus Lateralis Muscles in Humans.” J Appl Physiol (1985). 2013 May;114(9):1235-45. Epub 2012 Dec 20. PMID: 23264538. PMCID: PMC3656432.
  56. Quatromoni JG, Suzuki E, Okusanya O, Judy BF, Bhojnagarwala P, Venegas O, Eruslanov E, Predina JD, Albelda SM, Singhal S. “The Timing of TGF-β Inhibition Affects the Generation of Antigen-Specific CD8+ T Cells.” BMC Immunol. 2013 Jul 17;14:30. PMID: 23865808. PMCID: PMC3725164.
  57. Li T, Su L, Zhong N, Singhal S, Liu X “Salinomycin Induces Cell Death with Autophagy Through Activation of Endoplasmic Reticulum Stress in Human Lung Cancer Cells.” Autophagy. 2013 Jul;9(7). Epub 2013 Apr 18. PMID: 23670030. PMCID: PMC3722315.
  58. Fedor D, Johnson WR, Singhal S. “Local Recurrence Following Lung Cancer Surgery: Incidence, Risk Factors, and Outcomes.” Surg Oncol. 2013 Sep;22(3):156-61. PMID: 23702313. PMCID: PMC4131285.
  59. Liu Y, Wang L, Predina J, Han R, Beier UH, Bhatti TR, Akimova T, Singhal S, Brindle PK, Cole PA, Albelda SM, Hancock WW. “Inhibition of p300 Impairs Foxp3+ T-Regulatory Cell Function and Promotes Anti-Tumor Immunity.” Nat Med. 2013 Sep;19(9):1173-7. Epub 2013 Aug 18. PMID: 23955711. PMCID: PMC3793393.
  60. Ghosh A, Philiponis G, Lee JY, Leahy KP, Singhal S, Cohen NA, Mirza N. "Pulse Steroid Therapy Inhibits Murine Subglottic Granulation." Otolaryngol Head Neck Surg. 2013 Feb;148(2):284-90. Epub 2012 Nov 21. PMID: 23172907.
  61. Haft S, Lee JY, Ghosh A, Philiponis G, Malaisrie N, Leahy KP, Singhal S, Cohen NA, Mirza N. “Inflammatory Protein Expression in Human Subglottic Stenosis Tissue Mirrors that in a Murine Model.” Ann Otol Rhinol Laryngol. 2014 Jan;123(1):65-70. PMID: 24574426.
  62. Singhal S, Atluri S, Changela K, Gupta SS, Krishnaiah M, Anand S. “Endoscopic Closure of Gastric Perforation Using Over-the-Scope Clip: A Surgery-Sparing Approach.” Gastrointest Endosc. 2014 Jan;79(1):23. PMID: 24021487.
  63. Johnson WR, Fedor D, Singhal S. “Systematic Review of Surgical Treatment Techniques for Adult and Pediatric Patients with Pectus Excavatum.” J Cardiothorac Surg. 2014 Feb 7;9: 25. PMID: 24506826. PMCID: PMC3922335.
  64. Quatromoni JG, Predina JD, Bhojnagarwala P, Judy RP, Jiang J, De Jesus EM, Kapoor V, Cheng G, Okusanya OT, Eruslanov E, Singhal S. “Adenoviral Based Immunotherapy Provides Local Disease Control in an Orthotopic Murine Model of Esophageal Cancer.” J Immunother. 2014 Jun;27(5):283-292. PMID: 24810640. PMCID: PMC4552447.
  65. Yan J, Zhong N, Liu G, Chen K, Liu X, Su L, Singhal S. “Usp9x- and Noxa-Mediated Mcl-1 Down-Regulation Contributes to Pemetrexed-Induced Apoptosis in h=Human Non-Small Cell Lung Cancer Cells.” Cell Death Dis. 2014 Jul 3;5:e1316. PMID: 24991768. PMCID: PMC4123075.
  66. Holt D, Okusanya OT, Judy R, Venegas O, Jiang J, DeJesus E, Eruslanov E, Quatromoni J, Bhojnagarwala P, Deshpande C, Albelda S, Nie S, Singhal S. “Intraoperative Near-Infrared Imaging can Distinguish Cancer from Normal Tissue but not Inflammation.” PLoS One. 2014 Jul 29;9(7):e103342. PMID: 25072388. PMCID: PMC4114746.
  67. Mishalian I, Eruslanov E, Bayuch R, Levy L, Zolotorov L, Singhal S, Albelda SM, Fridlender ZG. “Neutrophils Recruit Regulatory T Cells into the Tumor via Secretion of CCL17: A New Mechanism of Tumor Immune Surveillance.” Int J Cancer. 2014 Sep 1;135(5):1178-1186. PMID: 24501019.
  68. Akimova T, Xiao H, Liu Y, Bhatti TR, Jiao J, Eruslanov E, Singhal S, Wang L, Han R, Zacharia K, Hancock WW, Beier UH. “Targeting Sirtuin-1 Alleviates Experimental Autoimmune Colitis by Induction of Foxp3+ T-Regulatory Cells.” Mucosal Immunity. 2014 Sep;7(5):1209-20. Epub 2014 Feb 19. PMID: 24549276. PMCID: PMC4138288.
  69. Hooijman PE, Paul MA, Stienen GJ, Beishuizen A, Van Hees HW, Singhal S, Bashir M, Budak MT, Morgen J, Barsotti RJ, Levine S, Ottenheijm CA. “Unaffected Contractility of Diaphragm Muscle Fibers in Humans on Mechanical Ventilation.” Am J Physiol Lung Cell Mol Physiol. 2014 Sep 15;307(6):L460-70. PMID: 25038190. PMCID: PMC4166782.
  70. Kruklitis RJ, Fishbein I, Singhal S, Kapoor V, Levy RJ, Alferiev IS, Sterman DH. “Stent-Mediated Gene Delivery for Site-Specific Transgene Administration to the Airway Epithelium and Management of Tracheobronchial Tumors.” Respiration. 2014;88(5):406-17. Epub 2014 Oct 16. PMID: 25323160.
  71. Okusanya O, Holt D, Heitjan D, Deshpande C, Venegas O, Jiang J, Judy R, DeJesus E, Madajewski B, Albelda SM, Nie S, Singhal S. “Intraoperative Near-Infrared Imaging Can Identify Pulmonary Nodules.” Ann Thorac Surg. 2014 Oct;98(4):1223-30. PMID: 25106680. PMCID: PMC4185369.
  72. Wormser C, Singhal S, Holt DE, Runge JJ. “Thoracoscopic-Assisted Pulmonary Surgery for Partial and Complete Lung Lobectomy in Dogs and Cats: 11 Cases (2008-2013).” J Am Vet Med Assoc. 2014 Nov 1;245(9):1036-41. PMID: 25313815.
  73. Okusanya OT, Deshpande C, Barbosa EM, Aggarwal C, Simone CB, Jiang J, Judy R, DeJesus E, Albelda S, Nie S, Low P, Singhal S. “Molecular Imaging to Identify Tumor Recurrence Following Chemoradiation in a Hostile Surgical Environment.” Mol Imaging. 2014 Nov;13. PMID: 25442640.
  74. Eruslanov E, Bhojnagarwala PS, Quatromoni JG, Stephen TL, Ranganathan A, Deshpande C, Akimova T, Vachani A, Litzky L, Hancock WW, Conejo-Garcia JR, Feldman M, Albelda SM, Singhal S. “Tumor-Associated Neutrophils Stimulate T Cell Responses in Early Stage Human Lung Cancer.” J Clin Invest. 2014 Dec;124(12):5466-80. PMID: 25384214. PMCID: PMC4348966.
  75. Singhal S, Kucharczuk JC. “Total Pectus Excavatum Repair: Open Approach.” Oper Tech Thorac Cardiovasc Surg. 2014;19(3):348-364. DOI: 10.1053/j.optechstcvs.2014.10.002.
  76. Singhal S, Inventor; Google Patents, assignee. “Methods for Medical Imaging.” US20150030542 A1. 2015.
  77. Quatromoni JG and Singhal S (co-first authors), Bhojnagarwala P, Hancock W, Albelda SM, Eruslanov E. “An Optimized Disaggregation Method for Human Lung Tumors that Preserves the Phenotype and Function of the Immune Cells.” J Leukoc Biol. 2015 Jan;97(1):201-9. PMID: 25359999. PMCID: PMC4771617.
  78. Keating J, Kennedy G, Singhal S. “Identification of a Subcentimeter Pulmonary Adenocarcinoma Using Intraoperative Near-Infrared Imaging During Video-Assisted Thoracoscopic Surgery.” J Thorac Cardiovasc Surg. 2015 Mar;149(3):e51-3. Epub 2014 Oct 22. PMID: 25827389.
  79. Shen J, Putt KS, Visscher DW, Murphy L, Cohen C, Singhal S, Sandusky G, Yang F, Dimitrov DS, Low PS. “Assessment of Folate Receptor-β Expression in Human Neoplastic Tissues.” Oncotarget. 2015 Jun 10;6(16):14700-9. PMID: 25909292. PMCID: PMC4546498.
  80. Jiang JX, Keating JJ, De Jesus EM, Judy RP, Madajewski B, Venegas O, Okusanya OT, Singhal S. “Optimization of the Enhanced Permeability and Retention Effect for Near-Infrared Imaging of Solid Tumors with Indocyanine Green.” Am J Nucl Med Mol Imaging. 2015 Jun 15;5(4):390-400. eCollection 2015. PMID: 26269776. PMCID: PMC4529592.
  81. Holt D, Parthasarathy AB, Okusanya O, Keating J, Venegas O, Yodh AG, Deshpande C, Karakousis G, Madajewski B, Durham A, Nie S, Singhal S. “Intraoperative Near-Infrared Fluorescence Imaging and Spectroscopy Identifies Residual Tumor Cells in Wounds.” J Biomed Opt. 2015 Jul;20(7):76002. PMID: 26160347. PMCID: PMC4497968.
  82. Kennedy GT, Judy BF, Bhojnagarwala P, Moon EK, Fridlender ZG, Albelda SM, Singhal S. “Surgical Cytoreduction Restores the Antitumor Efficacy of a Listeria Monocytogenes Vaccine in Malignant Pleural Mesothelioma.” Immunol Lett. 2015 Jul;166(1):28-35. PMID: 25999306. PMCID: PMC4476929.
  83. Okusanya O, DeJesus E, Jiang J, Judy R, Venegas O, Deshpande C, Heitjan DF, Nie S, Low P, Singhal S. “Intraoperative Targeted Molecular Imaging Can Identify Lung Adenocarcinomas During Pulmonary Resection.” J Thorac Cardiovasc Surg. 2015 Jul;150(1):28-35.e1. PMID: 26126457. PMCID: PMC4828933.
  84. De Jesus EM, Keating JJ. Kularatne SA, Jiang JX, Judy R, Predina J, Nie S, Low P, Singhal S. “Comparison of Folate Receptor Targeted Optical Contrast Agents for Intraoperative Molecular Imaging.” Int J Mol Imaging. 2015;2015:469047. Epub 2015 Sep 28. PMID: 26491562. PMCID: PMC4600912.
  85. Karaksheva TA, Waldron TJ, Eruslanov E, Lee JS, O’Brien S, Basu D, Singhal S, Malavasi F, Rustgi AK. “CD38-Expressing Myeloid-Derived Suppressor Cells Promote Tumor Growth in a Murine Model of Esophageal Cancer.” Cancer Res. 2015 Oct 1;75(19):4074-85. PMID: 26294209. PMCID: PMC4592477.
  86. Kennedy GT, Okusanya OT, Keating JJ, Heitjan DF, Deshpande C, Litzky LA, Albelda SM, Drebin JA, Nie S, Low PS, Singhal S. “The Optical biopsy: A Novel Method for Rapid Intraoperative Diagnosis of Primary Pulmonary Adenocarcinomas.” Ann Surg. 2015 Oct;262(4):602-9. PMID: 26366539.
  87. Judy RP, Keating JJ, DeJesus EM, Jiang JX, Okusanya OT, Nie S, Holt DE, Arlauckas SP, Low PS, Delikatny EJ, Singhal S. “Quantification of Tumor Fluorescence During Intraoperative Cancer Optical Imaging.” Sci Rep. 2015 Nov 13;5:16208. PMID: 26563091. PMCID: PMC4643322.
  88. Keating JJ, Nims S, Venegas O, Jiang J, Holt D, Kucharczuk JC, Deshpande C, Singhal S. "Intraoperative Imaging Identifies Thymoma Margins Following Neoadjuvant Chemotherapy." Oncotarget. 2016 Jan 19;7(3);3059-67. PMID: 26689990. PMCID: PMC4823090.
  89. Keating J, Judy R, Newton A, Singhal S. “Near-Infrared Operating Lamp for Intraoperative Molecular Imaging of a Mediastinal Tumor.” BMC Med Imaging. 2016 Feb 17;16:15. PMID: 26883511. PMCID: PMC4756470.
  90. Guzzo T, Jiang J, Keating JJ, DeJesus EM, Judy RP, Nie S, Low P, Lal P, Singhal S. “Intraoperative Molecular Diagnostic Imaging Can Identify Renal Cell Carcinoma.” J Urol. 2016 Mar;195(3):748-55. Epub 2015 Nov 2. PMID: 26541080.
  91. Predina JD, Keating J, Patel N, Nims S, Singhal S. "Clinical Implications of Positive Margins Following Non-Small Cell Lung Cancer Surgery." J Surg Oncol. 2016 Mar;113(3):264-9. Epub 2015 Dec 30. PMID: 26719121.
  92. Vogel J, Berman AT, Lin L, Pechet TT, Levin WP, Gabriel P, Khella S, Singhal S, Kucharczuk JC, Simone C. “Prospective Study of Proton Beam Radiation Therapy for Adjuvant and Definitive Treatment of Thymoma and Thymic Carcinoma: Early Response and Toxicity Assessment. Radiother Oncol. 2016 Mar;118(3):504-9. PMID: 26895711.
  93. Boogerd LS, Boonstra MC, Beck AJ, Charehbili A, Hoogstins CE, Prevoo HA, Singhal S, Low PS, van de Velde CJ, Vahrmeijer AL. “Concordance of Folate Receptor-α Expression Between Biopsy, Primary Tumor and Metastasis in Breast Cancer and Lung Cancer Patients.” Oncotarget. 2016 Apr 5;7(14):17442-54. PMID: 26943581. PMCID: PMC4951224.
  94. Ghosh, A, Leahy, K.P., Singhal, S, Einhorn, E, Howlett, P., Cohen, NA and Mirza, N. “A Murine Model of Subglottic Granulation.” J Laryngol Otol. 2016 Apr;130(4):380-7. PMID: 26991876.
  95. Keating JJ, Fisher C, Batiste R, Singhal S. “Advances in Intraoperative Margin Assessment for Breast Cancer.” Curr Surg Rep. 2016 Apr;4:15. Epub 2016 March 26. DOI: 10.1007/s4013701601363.
  96. Keating JJ, Tchou J, Okusanya O, Fisher C, Batiste R, Jiang J, Kennedy G, Nie S, Singhal S. “Identification of Breast Cancer Margins Using Intraoperative Near-Infrared Imaging.” J Surg Oncol. 2016 Apr;113(5):508-14. Epub 2016 Feb 4. PMID: 26843131.
  97. Keating JJ, Okusanya OT, DeJesus E, Judy RP, Jiang J, Deshpande C, Nie S, Low P, Singhal S. “Intraoperative Molecular Imaging of Lung Adenocarcinoma Can Identify Residual Tumor Cells at Surgical Margins.” Mol Imaging Biol. 2016 Apr:18(2):209-18. PMID: 26228697.
  98. Predina JD, Keating J, Venegas O, Nims S, Singhal S. “Neoadjuvant Intratumoral Immuno-Gene Therapy for Non-Small Cell Lung Cancer.” Discov Med. 2016 Apr; 21(116):275-81. PMID: 27232513.
  99. Keating J, Singhal S. “Novel Methods of Intraoperative Localization and Margin Assessment of Pulmonary Nodules.” Semin Thorac Cardiovasc Surg. 2016 Spring;28(1):127-36. Epub 2016 Feb 4. PMID: 27568150.
  100. Gaffey AC, Ball C, Katz S, Singhal S. “Partial Anomalous Venous Drainage of the Left Upper Lobe During a Robot-Assisted Pulmonary Resection.” J Thorac Dis. 2016 Jul (8):7:517-9. PMID: 27499986. PMCID: PMC4958882.
  101. Singhal S, Bhojnagarwala PS, O’Brien S, Moon EK, Garfall AL, Rao A, Quatromoni JG, Stephen TL, Litzky L, Deshpande C, Feldman M, Hancock WW, Conejo-Garcia JR, Albelda SM, Eruslanov EB. “Origin and Role of a Subset of Tumor-Associated Neutrophils with Antigen Presenting Cell Features (Hybrid TANs) in Early-Stage Human Lung Cancer.” Cancer Cell. 2016 Jul 11;30(1):120-135. PMID: 27374224. PMCID: PMC4945447.
  102. Svoronos N, Perales-Puchalt A, Allegrezza MJ, Rutkowski MR, Tesone1 AJ, Payne K, Nguyen JM, Curiel TJ, Cadungog MG, Albelda SM, Singhal S, Eruslanov EB, Tchou J, Zhang R, Conejo-Garcia JR. “Tumor Cell-Independent Estrogen Signaling Drives Malignant Progression Through MDSC Mobilization.” Cancer Discovery. 2016 Sep 30. pii: CD-16-0502. (Epub ahead of print). PMID: 27694385.
  103. Newton A, Kennedy G, Predina J, Low P, Singhal S. "Intraoperative Molecular Imaging to Identify Lung Adenocarcinomas." J Thorac Dis. 2016 Oct;8(Suppl 9):S697-S704. PMID: 281066672. PMCID: PMC5179345.
  104. Lee J, Thawani J, Pierce J, Zeh R, Martinez-Lage M, Learned K, Chanin M, Venegas O, Nims S, Keating J, Singhal S. “Intraoperative Near-Infrared Optical Imaging Can Localize Gadolinium-Enhanced Gliomas During Surgery.” Neurosurgery. 79(6): 856-871, 2016 Oct 11. (Epub ahead of print). PMID: 27741220.
  105. Keating J, Newton A, Venegas O, Nims S, Zeh R, Predina J, Deshpande C, Kucharczuk J, Nie S, Delikatny J, Singhal S. “Near-Infrared Intraoperative Molecular Imaging can Locate Metastases to the Lung.” Annals of Thoracic Surgery. 103(2) 390-398. PMID: 27793401
  106. Keating J, Runge J, Singhal S, Nims S, Venegas O, Durham A, Swain G, Nie S, Low P, Holt D. “Intraoperative Near-Infrared Fluorescence Imaging Targeting Folate Receptors Identifies Lung Cancer in a Large-Animal Model.” Cancer. 2016 Nov 7. DOI: 10.1002/cncr.30419.
  107. Eruslanov E, Albelda S, Singhal S. “Mouse Versus Human Neutrophils in Cancer – A Major Knowledge Gap.” Trends in Cancer. 2016 Dec. DOI: 10.1016/j.trecan.2016.12.006. 108. McMillan MT, Ojerholm E, Verma V, Higgins KA, Singhal S, Predina JD, Berman AT, Grover S, Robinson CG, Simone CB. “Radiotherapy Treatment Time and Overall Survival in Non-Small Cell Lung Cancer.” International Journal of Radiation Oncology. 98(5):1142-1152, 2017.